2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Lipoxygenase
  5. Lipoxygenase Inhibitor

Lipoxygenase Inhibitor

Lipoxygenase Isoform Comparison

Lipoxygenase Inhibitors (196):

Cat. No. Product Name Effect Purity
  • HY-120721
    Lagunamycin
    		Inhibitor
    Lagunamycin is a 5-lipoxygenase inhibitor isolated from the culture medium of Streptomyces sp. AA0310. Lagunamycin has a significant inhibitory activity against rat 5-lipoxygenase with an IC50 value of 6.08 μM. Lagunamycin can effectively inhibit 5-lipoxygenase without causing lipid peroxidation, indicating that it has an effective inhibitory effect without causing side effects.
  • HY-117784
    BI-L-357
    		Inhibitor
    BI-L-357 is a succinate derived from BI-L-226 that acts as a precursor, enhances oral bioavailability and inhibits 5-lipoxygenase-mediated leukotriene production.
  • HY-113807
    ZLJ-6
    		Inhibitor
    ZLJ-6 is a dual COX and 5-LOX inhibitor with oral activity. The IC50 values for COX-1, COX-2 and 5-LOX were 0.73, 0.31 and 0.99 μM, respectively. ZLJ-6 has anti-inflammatory and analgesic activity.
  • HY-19212
    S-2474
    		Inhibitor
    S-2474 is an inhibitor of COX-2 and 5-lipoxygenase (5-LO), with IC50s of 11 nM and 27 μM for COX-2 and COX-1 in human intact cells, and used as a nonsteroidal anti-inflammatory agent.
  • HY-N15453
    Asperenone
    		Inhibitor
    Asperenone is an inhibitor of 15-lipoxygenase (15-LOX) with an IC50 value of 0.3 mM. It is also an inhibitor of platelet aggregation, with an IC50 value of 0.23 mM. Additionally, Asperenone has antifungal activity and can inhibit the growth of pathogenic fungi Ophiostoma crassivaginatum and O. piliferum. Asperenone can be used in the research of cardiovascular diseases and anti-infection fields.
  • HY-14164S1
    Zileuton-13C2,15N
    		Inhibitor
    Zileuton-13C2,15N is 15N and 13C labeled Zileuton (HY-14164). Zileuton is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties.
  • HY-W706470
    (-)-Bornyl ferulate
    		Inhibitor
    (-)-Bornyl ferulate is a 5-lipoxygenase and COX inhibitor with IC50s of 10.4 μM and 12.0 μM, respectively.
  • HY-114830
    Fenleuton
    		Inhibitor
    Fenleuton is a 5-lipoxygenase inhibitor. Fenleuton is promising for research of leukotriene-mediated inflammatory diseases.
  • HY-168768
    FerroLOXIN-1
    		Inhibitor
    FerroLOXIN-1 is a potent inhibitor of 15LOX-2 that selectively blocked production of pro-ferroptotic HOO-ETE-PE and protected against RSL3-induced ferroptosis. FerroLOXIN-1 closely interacted therein with 15LOX-2 only, and in particular with Y154, N155, W158.
  • HY-W028263
    6-Hydroxyflavanone
    		Inhibitor
    6-Hydroxyflavanone is a compound that can be isolated from the Muntingia calabura leaves. 6-Hydroxyflavanone targets cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), and opioid and GABA-A receptors that has anti-inflammatory and anti-neuropathic pain potential. 6-Hydroxyflavanone can be used for the research of diabetes.
  • HY-116080
    SB 210661
    		Inhibitor
    SB 210661 is a potent and selective 5-lipoxygenase inhibitor.
  • HY-U00260
    CMI977
    		Inhibitor
    CMI977 is a potent 5-Lipoxygenase (5-LO) inhibitor.
  • HY-U00347
    COX/5-LO-IN-1
    		Inhibitor
    COX/5-LO-IN-1 (Atreleuton analog) is an inhibitor of cylooxygenase and 5-lipoxygenase (5-LO), used for the research of inflammatory and allergic disease states.
  • HY-19205A
    CMI-392
    		Inhibitor
    CMI-392 is a dual 5-lipoxygenese inhibitor and platelet-activating factor (PAF) receptor antagonist with IC50s of 100 and 10 nM, respectively.
  • HY-U00217
    AZD 4407
    		Inhibitor
    AZD 4407 is a potent 5-lipoxygenase inhibitor.
  • HY-U00170
    Bunaprolast
    		Inhibitor
    Bunaprolast (U66858) is a potent inhibitor of LTB4 production in human whole blood. Bunaprolast (U66858) also exhibits significant inhibition of lipoxygenase and TXB2 release.