Lipoxygenase Inhibitor

Lipoxygenase Inhibitors (196):

Cat. No.	Product Name	Effect	Purity

HY-W009248

Phenethyl ferulate	Inhibitor	99.88%
Phenethyl ferulate is a major constituent ofQianghuo, shows inhibitory activity against cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) with IC₅₀ values of 4.35 μM and 5.75 μM, respectively.

HY-N6079

Timosaponin A1	Inhibitor	99.70%
Timosaponin A1, a natural steroidal saponin, is a 5-lipoxygenase (5-LO), COX-2, and dipeptidyl peptidase 4 (DPP-4) inhibitor with IC₅₀s of 3.29 µM, 36.43 µM, and 33.25 µM, respectively.

HY-127170

3-Hydroxycoumarin	Inhibitor	99.30%
3-hydroxycoumarin is a potent and redox inhibitor of human 15-LOX-1. 3-hydroxycoumarin is recently demonstrated to protect sea urchin reproductive cells against ultraviolet B damage.

HY-106200

CJ-13,610	Inhibitor	98.01%
CJ-13,610, a nonredox-type 5-LO inhibitor, dose dependently suppresses 5-LO product formation in ionophore A23187-stimulated PMNL in the absence of exogenous AA with an IC₅₀ of about 70 nM. PMNL: polymorphonuclear leukocytes; AA: arachidonic acid

HY-121585

CAY10698	Inhibitor	99.28%
CAY10698 (compound 1) is a potent and selective inhibitor of 12-Lipoxygenase (12-LOX) with an IC₅₀ of 5.1 μM. CAY10698 is inactive against 5-LOX, 15-LOX-1, 15-LOX-2 and COX-1/2.

HY-101051

2-TEDC	Inhibitor	99.55%
2-TEDC is a potent inhibitor of 5-, 12-, and 15-lipoxygenase with IC₅₀ values of 0.09 μM, 0.013 μM and 0.5 μM, respectively. 2-TEDC can be used for the research of atheroscrelosi.

HY-119822

Texasin	Inhibitor	99.51%
Texasin is a natural product that can be isolated from Baptisia australis.

HY-N3535

Canniprene	Inhibitor	≥98.0%
Canniprene, an isoprenylated bibenzyl unique to Cannabis sativa, is a potent inhibitor of 5-lipoxygenase (5-LO) activity (IC₅₀=0.4 μM) and cyclooxygenase/microsomal prostaglandin E2 synthase (PGE₂; IC₅₀=10 μM). Canniprene inhibits the production of inflammatory eicosanoids and affects the generation of prostaglandins.

HY-N7162

3-O-Acetyl-11-hydroxy-beta-boswellic acid	Inhibitor	98.98%
3-O-Acetyl-11-hydroxy-beta-boswellic acid is a potent 5-lipoxygenase (5-LO) inhibitor.

HY-138939

5-LOX-IN-2	Inhibitor	98.75%
5-LOX-IN-2, an inhibitor of 5-lipoxygenase (5-LOX) with an IC₅₀ of 0.33 μM, inhibits 5-LOX in a dose-dependent manner . 5-LOX-IN-2, reduces the cell viability of renal cancer cells and induces apoptosis, can be used for cancer research.

HY-N2074

Picrinine	Inhibitor	99.33%
Picrinine, an akuammiline alkaloid, is isolated from the leaves of Alstonia scholaris. Picrinine exhibits anti-inflammatory activity through inhibition of the 5-lipoxygenase enzyme.

HY-119671

BW 755C	Inhibitor
BW 755C is a 5-lipoxygenase (5-LO) inhibitor with an IC₅₀ of 5 μM. BW 755C also inhibits cyclooxygenase (COX) with IC₅₀s of 0.65 and 1.2 μg/mL against COX-1 and COX-2, respectively.

HY-N8276

Ro 3-1314	Inhibitor	≥99.0%
Ro 3-1314 (9a,12a-Octadecadiynoic acid) is a plant lipoxygenase inhibitor. Ro 3-1314 is a linoleic acid metabolism inhibitor. Ro 3-1314 stimulates the antigen-induced contraction of guinea-pig tracheal spirals and the immunological release of slow reacting substance of anaphylaxis (SRS-A) from actively sensitized guinea-pig lung fragments.

HY-148134

5-LOX-IN-1	Inhibitor	98.04%
5-LOX-IN-1 (compound 2b) is an inhibitor of human 5-Lipoxygenase (5-LOX) with an IC₅₀ value of 2.3 μM. 5-LOX-IN-1 can be used for the research of inflammation.

HY-101587

(E)-KME-4	Inhibitor	99.51%
(E)-KME-4 is a potent inhibitor of prostaglandin synthetase (PGS) with an IC₅₀ of 0.28 μM; also inhibits 5-lipoxygenase with an IC₅₀ of 1.05 μM.

HY-124252

5,8,11-Eicosatriynoic acid	Inhibitor	≥99.0%
5,8,11-Eicosatriynoic acid (ETI) is a lipoxygenase inhibitor that blocks LTC4 biosynthesis in mast cell tumor cells.

HY-106823

Tebufelone	Inhibitor	99.52%
Tebufelone (NE-11740), a nonsteroidal anti-inflammatory drug (NSAID), is a selective dual COX-2/5-lipoxygenase inhibitor. Tebufelone displays potent anti-inflammatory, analgesic and anti-pyretic properties.

HY-N9834

Aureusidin	Inhibitor
Aureusidin is an aurone with high antioxidant and lipoxygenase inhibitory activity. Aureusidin also shows anti-inflammatory effects.

HY-158204

CNB-001	Inhibitor
CNB-001 is a potent 5-lipoxygenase (5-LOX) inhibitor, decreases 5-LOX expression, and increases proteasome activity. CNB-001 also increases eIF2α phosphorylation and HSP90 and ATF4 levels in Alzheimer's disease transgenic mice, and limits the accumulation of soluble Aβ and ubiquitinated aggregated proteins. CNB-001 maintains the expression of synapse-associated proteins and improves memory. CNB-001 can be used for the research of Alzheimer's disease.

HY-118480

4-MMPB	Inhibitor	98.54%
4-MMPB is a selective inhibitor of 15-lipoxygenase, with an IC₅₀ of 18 μM. 4-MMPB has IC₅₀s of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively. 4-MMPB has potential for the research of prostate cancer.

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