Adenosine Receptor Inhibitor

Adenosine Receptor Inhibitors (20):

Cat. No.	Product Name	Effect	Purity

HY-N0138

Theobromine	Inhibitor	99.78%
Theobromine is a methylxanthine found in cacao beans which can inhibit adenosine receptor A1 (AR1) signaling.

HY-B0153A

Ticlopidine hydrochloride	Inhibitor	99.99%
Ticlopidine hydrochloride is an adenosine diphosphate (ADP) receptor inhibitor against platelet aggregation with IC50 of ~2 μM.

HY-B0809S

Theophylline-d₆	Inhibitor	99.90%
Theophylline-d₆ is the deuterium labeled Theophylline. Theophylline is a nonselective phosphodiesterase (PDE) inhibitor, adenosine receptor blocker, and histone deacetylase (HDAC) activator.

HY-100130

N-[(4-Aminophenyl)methyl]adenosine	Inhibitor	98.68%
N-[(4-Aminophenyl)methyl]adenosine is a adenosine receptor inhibitor, with Ki of 29 nM for Rat ecto-5′-Nucleotidase.

HY-14117

Enprofylline	Inhibitor	99.22%
Enprofylline acts as a selective and competitive A2B receptor antagonist with the K_i of 7 μM. Enprofylline also acts as a phosphodiesterase inhibitor. Enprofylline can be used for the research of asthma, chronic obstructive pulmonary disease.

HY-N0138S1

Theobromine-d₃	Inhibitor	99.78%
Theobromine-d₃ is the deuterium labeled Theobromine. Theobromine is a methylxanthine found in cacao beans which can inhibit adenosine receptor A1 (AR1) signaling.

HY-111767

BAY-545	Inhibitor	98.18%
BAY-545 is a potent and selective A_2B adenosine receptor antagonist, with an IC₅₀ of 59 nM. BAY-545 also exhibits IC₅₀s of 66, 400, 280 nM for human, mouse, rat A_2B adenosine receptor in cells, respectively, and a K_i of 97 nM for human A_2B adenosine receptor, with more selectivity over A₁, A_2A, and A₃ adenosine receptor.

HY-N0138S

Theobromine-d₆	Inhibitor	≥98.0%
Theobromine-d₆ is the deuterium labeled Theobromine. Theobromine is a methylxanthine found in cacao beans which can inhibit adenosine receptor A1 (AR1) signaling.

HY-145406

IHCH-3064	Inhibitor
IHCH-3064 is a dual-acting compounds targeting Adenosine A2A Receptor and HDAC. IHCH-3064 exhibits potent binding to A2AR (Ki=2.2 nM) and selective inhibition of HDAC1 (IC50=80.2 nM), with good antiproliferative activity against tumor cell lines in vitro. IHCH-3064 is a tumor immunotherapeutic agent.

HY-103177

PSB-10 hydrochloride	Inhibitor
PSB-10 hydrochloride is a potent and selective antagonist of human adenosine A3 receptor (A₃AR), with a K_i of 0.44 nM. PSB-10 hydrochloride shows more than 800-fold selectivity for hA₃ over rA₁, rA_2A, hA₁, hA_2A and hA_2B receptors (K_i=805, 6040, 1700, 2700, 30000 nM, respectively). PSB-10 hydrochloride produces thermal hyperalgesia in mice.

HY-B0153AS

Ticlopidine-d₄ hydrochloride	Inhibitor
Ticlopidine-d₄ (hydrochloride) is the deuterium labeled Ticlopidine hydrochloride. Ticlopidine hydrochloride is an adenosine diphosphate (ADP) receptor inhibitor against platelet aggregation with IC50 of ~2 μM.

HY-112658

p-Iodoclonidine hydrochloride	Inhibitor
p-Iodoclonidine hydrochloride is a partial agonist of α2-adrenergic receptor. p-Iodoclonidine hydrochloride also has minimal agonist activity in inhibiting adenylate cyclase in platelet membranes, and potentiates ADP induced platelet aggregation with an EC₅₀ of 1.5 μM.

HY-N0138R

Theobromine (Standard)	Inhibitor
Theobromine (Standard) is the analytical standard of Theobromine. This product is intended for research and analytical applications. Theobromine is a methylxanthine found in cacao beans which can inhibit adenosine receptor A1 (AR1) signaling.

HY-N0127R

Yohimbine Hydrochloride (Standard)	Inhibitor
Yohimbine Hydrochloride Standard is an alpha-2 renal adenomatase receptor inhibitor, blocking pre- and post-contact alpha-2 renal adenomatase receptors, causing the release of renal adenoma and multiple sclerosis.

HY-120826

A2AAR/hMAO-B-IN-1	Inhibitor
A2AAR/hMAO-B-IN-1 (compoudn 17) is a non-xanthine dual-target inhibitor targeting the A2A adenosine receptor (A2AAR) (IC₅₀: 34.9 nM) andMAO-B (Ki: 39.5 nM, human). A2AAR/hMAO-B-IN-1 inhibits A2AAR-induced cAMP accumulation and exhibits competitive, reversible inhibition of MAO-B. A2AAR/hMAO-B-IN-1 can be used in the study of neurodegenerative diseases such as Parkinson's disease (PD).

HY-B0153AR

Ticlopidine hydrochloride (Standard)	Inhibitor
Ticlopidine (hydrochloride) (Standard) is the analytical standard of Ticlopidine (hydrochloride). This product is intended for research and analytical applications.

HY-143325

A2AAR/HDAC-IN-2	Inhibitor
A2AAR/HDAC-IN-2 is a potent A_2AAR/HDAC dual inhibitor, with good binding affinity for A_2AAR (K_i=10.3 nM) and good inhibitory activity against HDAC1 (IC₅₀=18.5 nM). A2AAR/HDAC-IN-2 can be used in study of antitumor.

HY-123196

CVT-2759	Inhibitor
CVT-2759 is a potent inhibitor of A₁-ADOR, with the IC₅₀ values of 0.18 μM and 9.5 μM to reduce the binding of [3H]CPX in the absence and presence of 1 mM GTP. CVT-2759 plays an important role in slowing AV nodal conduction and thereby ventricular rate without causing AV block, bradycardia, atrial arrhythmias, or vasodilation.

HY-B0809S1

Theophylline-d₃	Inhibitor
Theophylline-d₃ is deuterated labeled Theophylline (HY-B0809). Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research.

HY-U00180

KF21213	Inhibitor
KF21213 is a highly selective ligand for mapping CNS adenosine A_2A receptors. KF21213 shows a high affinity for the adenosine A_2A receptors (K_i=3.0 nM).

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