2. Signaling Pathways
  3. Autophagy
  4. Atg7

Atg7

 

Atg7 Related Products (6):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-146130
    ATG7-IN-2
    		99.22%
    ATG7-IN-2 (compound 1) is a potent ATG7 inhibitor, with an IC50 of 0.089 μM. ATG7-IN-2 inhibits autophagy marker LC3B.
    ATG7-IN-2
  • HY-N0538
    Xylitol
    		Activator ≥98.0%
    Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model.
    Xylitol
  • HY-146131
    ATG7-IN-3
    		99.26%
    ATG7-IN-3 (compound 18) is a potent ATG7 inhibitor, with an IC50 of 0.048 μM. ATG7-IN-3 inhibits autophagy. ATG7-IN-3 inhibits the formation of endogenous LC3B puncta in the neuroglioma cell line H4.
    ATG7-IN-3
  • HY-145371
    ATG7-IN-1
    		Inhibitor 99.91%
    ATG7-IN-1 is a potent and selective inhibitor of ATG7 (IC50 = 62 nM).
    ATG7-IN-1
  • HY-151914
    Antitumor agent-82
    Antitumor agent-82 (compound 6g) is a potent anti-tumor agent. Antitumor agent-82 shows anti-proliferative activity. Antitumor agent-82 induces cell Autophagy by the ATG5/ATG7 signaling pathway.
    Antitumor agent-82
  • HY-170594
    Antitumor agent-192
    Antitumor agent-192 (Compound 2f) is a β-carboline antitumor agent. Antitumor agent-192 induces autophagy in HCT116 cells via the ATG5/ATG7 pathway. Antitumor agent-192 has an IC50 of less than 5 μM for human tumor cell lines and significantly inhibits tumor development and reduces tumor weight in a mouse colorectal cancer model transplanted with allografts[1].
    Antitumor agent-192