2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. CRM1
  5. CRM1 Inhibitor

CRM1 Inhibitor

CRM1 Inhibitors (15):

Cat. No. Product Name Effect Purity
  • HY-17536
    Selinexor
    		Inhibitor 99.85%
    Selinexor (KPT-330), analog of KPT-185, is an orally bioavailable and selective CRM1 inhibitor.
  • HY-16909
    Leptomycin B
    		Inhibitor 99.94%
    Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle.
  • HY-100423
    Eltanexor
    		Inhibitor 99.84%
    Eltanexor (KPT-8602) is a second-generation, highly specific and orally active exportin-1 (XPO1) inhibitor with potent anti-leukemic activity. Eltanexor (KPT-8602) inhibits XPO1-dependent nuclear export (EC50=60.9 nM) by directly targeting XPO1. Eltanexor (KPT-8602) induces Caspase-dependent apoptosis in a panel of leukemic cell lines.
  • HY-15970
    Verdinexor
    		Inhibitor 99.91%
    Verdinexor (KPT-335) is an orally active inhibitor for selective inhibitor of nuclear export (SINE). Verdinexor inhibits the respiratory syncytial virus A2 (RSV A2) replication with an IC50 of 0.96 µM. Verdinexor inhibits the function of nuclear export protein Exportin 1 (XPO1/CRM1), inhibiting pro-inflammatory responses. Verdinexor exhibits antitumor effciency.
  • HY-117996
    KPT-251
    		Inhibitor 99.92%
    KPT-251 is an orally active chromosome region maintenance 1 protein (CRM1) inhibitor. KPT-251 induces cancer cell apoptosis and shows antileukemic activity.
  • HY-108716
    Felezonexor
    		Inhibitor 98.84%
    CBS9106 (SL-801) is a reversible oral CRM1 inhibitor with CRM1 degrading and antitumor activities. CBS9106, inhibits CRM1-dependent nuclear export, causing arrest of the cell cycle and inducing apoptosis in a time- and dose-dependent manner for a broad spectrum of cancer cells.
  • HY-100423A
    Eltanexor Z-isomer
    		Inhibitor
    Eltanexor Z-isomer (KPT-8602 Z-isomer) is the less active isomer of KPT-8602.
  • HY-N6795
    Leptomycin A
    		Inhibitor ≥99.0%
    Leptomycin A, a Streptomyces metabolite, is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A suppresses HIV-1 replication. Less potent than Leptomycin B.
  • HY-155972A
    CRM1-IN-2
    		Inhibitor
    CRM1-IN-2 (Compound KL2) is a noncovalent CRM1 inhibitor. CRM1-IN-2 localizes CRM1 in the nuclear periphery, depletes nuclear CRM1, and inhibits CRM1-mediated nuclear export. CRM1-IN-2 inhibits growth of colorectal cancer cells, and induces apoptosis.
  • HY-155972
    CRM1-IN-1
    		Inhibitor
    CRM1-IN-1 (Compound KL1) is a noncovalent CRM1 inhibitor. CRM1-IN-1 induces nuclear CRM1 degradation (IC50: 0.27 μM). CRM1-IN-1 inhibits CRM1-mediated nuclear export and cell proliferation, and triggers apoptosis in colorectal cancer cells.
  • HY-160296
    AN-988
    		Inhibitor
    AN-988 (compund 6) is a covalent CRM1 inhibitor.
  • HY-157412
    CRM1-IN-3
    		Inhibitor
    CRM1-IN-3 (B28) is a noncovalent CRM1 inhibitor. CRM1-IN-3 can be used for the research of protein localization and tumor.
  • HY-114597
    PKF050-638
    		Inhibitor
    PKF050-638 is a potent and selective inhibitor of HIV-1 Rev (IC50=0.04 μM). PKF050-638 inhibits the CRM1-mediated Rev nuclear export by disrupting CRM1-NES interaction.
  • HY-17536R
    Selinexor (Standard)
    		Inhibitor
    Selinexor (Standard) is the analytical standard of Selinexor. This product is intended for research and analytical applications. Selinexor (KPT-330), analog of KPT-185, is an orally bioavailable and selective CRM1 inhibitor.
  • HY-163902
    SP100030 analogue 1
    		Inhibitor
    SP100030 analogue 1 (compound 11), a SP100030 (HY-110177) analogue, is a selective inhibitor of transcriptional activation (SITA) with an EC50 of 137 nM for suppressing the XPO1-dependent upregulation of IL2 by Jurkat-based IL2-Luc reporter assay.