2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Elastase

Elastase

Elastase

Related Products

PDF 0.41 MB

Elastase is a group of serine proteases that include the macrophage elastase, the fibroblast elastase, the neutrophil elastase, and the pancreatic elastase. Elastase can not only cleave the important connective tissue protein elastin, but also facilitate the degradation of the extracellular matrix such as fibronectin; laminin; collagens III, IV, and VI; and proteoglycans.

Mammalian elastases occur mainly in the pancreas and the phagocytes. Among non-mammalian elastases there is a great variety of bacterial metallo and serine elastases. The elastolytic activity varies from one elastase to another and is usually not correlated with the catalytic efficiency of these proteinases. There is a large number of natural (proteins) and synthetic elastase inhibitors. Elastases play a pathologic role in pulmonary emphysema, cystic fibrosis, infections, inflammation, and atherosclerosis.

Elastase Related Products (76):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-143206
    Tyrosinase/elastase-IN-1
    		Inhibitor
    Tyrosinase/elastase-IN-1 a triterpenoid from Rubus fraxinifolius leaves, has tyrosinase and elastase inhibitory activities.
    Tyrosinase/elastase-IN-1
  • HY-P5995
    MeOSuc-AAPA-CMK
    		Inhibitor
    MeOSuc-AAPA-CMK is a potent inhibitor of human neutrophil elastase.
    MeOSuc-AAPA-CMK
  • HY-155231
    Neutrophil elastase inhibitor 4
    		Inhibitor
    Neutrophil elastase inhibitor 4 (compound 4f) is a competitive human neutrophil elastase (HNE) inhibitor (IC50: 42.30 nM, Ki: 8.04 nM). Neutrophil elastase inhibitor 4 induces T47D cell apoptosis. Neutrophil elastase inhibitor 4 inhibits cell proliferation with IC50s of 21.25, 34.17, 29.93, 99.11 nM for T47D, RPMI 8226, A549, and HSF cells.
    Neutrophil elastase inhibitor 4
  • HY-106216
    Tiprelestat
    		Inhibitor
    Tiprelestat is a potent human neutrophil elastase inhibitor. Tiprelestat has antimicrobial and anti-inflammatory activities. Tiprelestat can be used in the research of inflammation/immune disease.
    Tiprelestat
  • HY-P4350
    Suc-Ala-Ala-Ala-AMC
    Suc-Ala-Ala-Ala-AMC is a peptide substrate of elastase or elastase-like.
    Suc-Ala-Ala-Ala-AMC
  • HY-120039A
    (S)-MDL-101146
    		Inhibitor
    (S)-MDL-101146 is the S-isomer of MDL-101146. MDL-101146 is an orally active, competitive and reversible inhibitor against human neutrophil elastase (HNE) with a Ki value of 25 nM. MDL-101146 inhibits HNE-induced hemorrhage in hamsters. MDL-101146 is promising for research of emphysema, rheumatoid arthritis, chronic bronchitis, cystic fibrosis, adult respiratory distress syndrome and glomerulonephritis.
    (S)-MDL-101146
  • HY-N2395R
    Chrysophanol 8-O-glucoside (Standard)
    		Inhibitor
    Chrysophanol 8-O-glucoside (Standard) is the analytical standard of Chrysophanol 8-O-glucoside. This product is intended for research and analytical applications. Chrysophanol 8-O-glucoside, from the roots of Rumex acetosa, shows moderate elastase inhibition activity.
    Chrysophanol 8-O-glucoside (Standard)
  • HY-W104758
    Elastase-IN-3
    		Inhibitor
    Elastase-IN-3 (Compound 2i) is an Elastase inhibitor of Pseudomonas aeruginosa. Elastase-IN-3 inhibits the quorum sensing system of Pseudomonas aeruginosa by targeting the LasR protein (KD value of 7.04 M), thereby preventing food spoilage caused by Pseudomonas aeruginosa.
    Elastase-IN-3
  • HY-124556
    Elasnin
    		Inhibitor
    Elasnin is a selective granulocyte elastase inhibitor. Elasnin is almost ineffective for pancreatic elastase, trypsin, chymotrypsin, thermolysin and papain.
    Elasnin
  • HY-162779
    CDD-3290
    		Inhibitor
    CDD-3290 (Compound 20) is a prostate-specific antigen (PSA) inhibitor with a Ki value of 216 nM. CDD-3290 also inhibits α-chymotrypsin and elastase.
    CDD-3290
  • HY-N11564
    Aristololactam IIIa
    		Inhibitor
    Aristololactam IIIa exhibits significant inhibitory effects on superoxide anion generation and elastase release with IC50 values of 0.12 and 0.20 μg/mL, respectively.
    Aristololactam IIIa
  • HY-117668
    MDL 101146
    		Inhibitor
    MDL 101146 is an orally active neutrophil elastase inhibitor. MDL 101146 inhibits neutrophil elastase for human with a Ki value of 25 nM. MDL 101146 can be used for the research of arthritis.
    MDL 101146
  • HY-146070
    Elastase-IN-1
    		Inhibitor
    Elastase-IN-1 (Compound Q11) is an elastase inhibitor with an IC50 of 0.897 µM. Elastase-IN-1 is non-toxic.
    Elastase-IN-1
  • HY-111515
    BAY-678 racemate
    		98.30%
    BAY-678 racemate is a racemate of BAY-678. BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).
    BAY-678 racemate
  • HY-126988
    SP-Chymostatin B
    		Inhibitor
    SP-Chymostatin B (α-MAPI) is a strong inhibitor of many proteases, including chymotrypsin, papain, chymotrypsin-like serine proteinases, chymases, and lysosomal cysteine proteinases such as cathepsins A,B,C, H, and L. SP-Chymostatin B weakly inhibits human leucocyte elastase.
    SP-Chymostatin B
  • HY-163411
    Neutrophil elastase inhibitor 6
    		Inhibitor
    Neutrophil elastase inhibitor 6 (compound 113) is an irreversible phosphonic-type inhibitor of human neutrophil elastase.
    Neutrophil elastase inhibitor 6
  • HY-118621
    JCP174
    		Inhibitor
    JCP174 is an inhibitor of palmitoyl protein thioesterase-1 (TgPPT1), a depalmitoylase in the parasite T. gondii. JCP174 is also an inhibitor of porcine pancreatic elastase and human leukocyte elastase.
    JCP174
  • HY-120039
    (R)-MDL-101146
    		Inhibitor
    (R)-MDL-101146 is the R-isomer of MDL-101146. MDL-101146 is an orally active, competitive and reversible inhibitor against human neutrophil elastase (HNE) with a Ki value of 25 nM. MDL-101146 inhibits HNE-induced hemorrhage in hamsters. MDL-101146 is promising for research of emphysema, rheumatoid arthritis, chronic bronchitis, cystic fibrosis, adult respiratory distress syndrome and glomerulonephritis.
    (R)-MDL-101146
  • HY-P3356
    Cyclotheonellazole A
    		Inhibitor
    Cyclotheonellazole A is a natural macrocyclic peptide and a potent elastase inhibitor (IC50=0.034 nM). Cyclotheonellazole A inhibits chymotrypsin with an IC50 value of 0.62 nM.
    Cyclotheonellazole A
  • HY-P4362
    Suc-Ala-Pro-Ala-AMC
    Suc-Ala-Pro-Ala-AMC is a tripeptide substrate of elastase.
    Suc-Ala-Pro-Ala-AMC