2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. FBPase

FBPase

fructose-1,6-bisphosphatase

FBPase, which catalyses the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate, is a rate-limiting enzyme responsible for gluconeogenesis and glyconeogenesis and, more generally, for the control of energy metabolism and glucose homeostasis. In mammals, two separate genes, FBP1 and FBP2, encode the liver and muscle isoforms of FBPase, respectively.

Lower FBPase expression frequently correlated significantly with an advanced tumour stage, a highly malignant phenotype, and worse prognoses in cancer patients. All these data implied that FBPase might be a novel biomarker and potential target for the treatment of cancer.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-16307
    MB05032
    		Inhibitor 99.66%
    MB05032 is a special and efficacious gluconeogenesis inhibitor targeted the AMP binding site of fructose 1,6-bisphosphatase (FBPase) with an IC50 value of 16 nM.
    MB05032
  • HY-136717
    FBPase-1 inhibitor-1
    		Inhibitor 99.10%
    FBPase-1 inhibitor-1 (compound 1) is a allosteric inhibitor of fructose-1,6-bisphosphatase (FBPase-1).
    FBPase-1 inhibitor-1
  • HY-14955
    Managlinat dialanetil
    		Inhibitor 98.13%
    Managlinat dialanetil (MB06322) is an orally bioavailable inhibitor of fructose 1,6-bisphosphatase (FBPase) for the treatment of type 2 diabetes .
    Managlinat dialanetil
  • HY-146725
    FBPase-IN-1
    		Inhibitor 98.30%
    FBPase-IN-1 is a potent FBPase (Fructose-1,6-bisphosphatase) inhibitor for Type 2 diabetes (T2D) study with an IC50 of 0.22 μM. FBPase-IN-1 can reduce blood glucose levels and ameliorate glucose tolerance. FBPase-IN-1 modifies the C128 site, regulates the N125-S124-S123 allosteric pathway of FBPase and affects the catalytic activity of FBPase.
    FBPase-IN-1
  • HY-168103
    FBPase-IN-3
    		Inhibitor
    FBPase-IN-3 (compound 45) is a FBPase (fructose-1,6-bisphosphatase) inhibitor with an IC50 of 2.08 μM. FBPase-IN-3 exhibits potent inhibitory activity of gluconeogenesis.
    FBPase-IN-3
  • HY-147645
    FBPase-IN-2
    		Inhibitor
    FBPase-IN-2 (HS36) is a potent Fructose-1,6-bisphosphatase (FBPase) covalent inhibitor with an IC50 of 0.15 μM. FBPase-IN-2 reduces glucose production in hepatocytes. FBPase-IN-2 can be used for type 2 diabetes mellitus research.
    FBPase-IN-2
Cat. No. Product Name / Synonyms Application Reactivity