2. Signaling Pathways
  3. GPCR/G Protein
  4. GnRH Receptor

GnRH Receptor

Gonadotropin releasing hormone receptor; GNRHR

GnRH Receptor

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The GnRH receptor (Gonadotropin-releasing hormone receptor, GNRHR) is a member of the rhodopsin-like G protein-coupled receptor (GPCR) family and consists of seven transmembrane helical domains connected via extra- and intra-cellular segments. GnRH receptor is located on the plasma membrane of gonadotrophs, pituitary cells that synthesize the gonadotrophins LH and FSH.

Mammalian type I and II GnRH receptors show differential ligand preference for GnRH-I (also named as LHRHR) and GnRH-II, respectively. All GnRH receptors activate the Gq/11 family of G proteins, which activate phospholipase C-catalyzed production of second messengers that activate protein kinase C (PKC). GnRH receptor activated by GnRH analogues stimulates the synthesis and release of LH and FSH. GnRH receptors can be used for the research of breast and prostate cancer, regulation of fertility, endometriosis and a range of other medical and veterinary uses.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-134864
    GnRH antagonist 2
    		Antagonist 98.58%
    GnRH antagonist 2 (formula I) is a GnRH receptor antagonist that can be used for endometriosis research.
    GnRH antagonist 2
  • HY-133080
    BAY-784
    		Antagonist 99.5%
    BAY-784 is a gonadotropin releasing hormone receptor (GnRH-R) antagonist probe with IC50s of 21 and 24 nM for human and rat GnRH-R, respectively.
    BAY-784
  • HY-P0009
    Cetrorelix
    		Antagonist
    Cetrorelix is a potent gonadotrophin-releasing hormone (GnRH) antagonist. Cetrorelix inhibits the endogenous luteinizing hormone surge during ovarian stimulation. Cetrorelix reduces cyclophosphamide induced ovarian follicular destruction in mice.
    Cetrorelix
  • HY-P1808
    LGnRH-III, lamprey
    		99.80%
    LGnRH-III, lamprey, an isoform of GnRH isolated from the sea lamprey, is a weak GnRH agonist with antitumor activities.
    LGnRH-III, lamprey
  • HY-P4572
    (D-Trp6)-LHRH free acid
    		Agonist 99.97%
    (D-Trp6)-LHRH free acid is a luteinizing hormone-releasing hormone (LHRH) agonist.
    (D-Trp6)-LHRH free acid
  • HY-P3582
    sGnRH-A
    		Agonist
    sGnRH-A is a salmon gonadotropin-releasing hormone (GnRH) analogue. sGnRH-A stimulates growth hormone secretion. sGnRH-A also can be used as an inducer of ovulation by artificial insemination.
    sGnRH-A
  • HY-13673
    Goserelin
    		Agonist
    Goserelin (ICI 118630), a decapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH), functions as a GnRH agonist. Goserelin can be used for the research of breast cancer, epithelial ovarian cancer and prostate cancer.
    Goserelin
  • HY-144863
    BAY 1214784
    		Antagonist 99.8%
    BAY 1214784 is a potent, selective, and orally active antagonist of the human gonadotropin-releasing hormone receptor (hGnRH-R). BAY 1214784 is a spiroindoline derivative compound. BAY 1214784 effectively lowers plasma luteinizing hormone levels by up to 49%, at the same time being associated with low pharmacokinetic variability and good tolerability. BAY 1214784 has the potential for the research of uterine fibroids.
    BAY 1214784
  • HY-151247
    GnRH-R antagonist 1
    		Antagonist
    GnRH-R antagonist 1 (compound 21a) is an orally safe and membrane-permeable GnRH-R antagonist with high binding affinity (IC50=0.57 nM) and potent in vitro antagonistic activity (IC50=2.18 nM). GnRH-R antagonist 1 can be used in studies of advanced prostate cancer and premature LH peaks preventing.
    GnRH-R antagonist 1
  • HY-152856
    Merigolix
    		Antagonist
    Merigolix is a potent gonadotrophin releasing hormone (GnRH) antagonist.
    Merigolix
  • HY-16168B
    Degarelix acetate hydrate
    		Antagonist
    Degarelix acetate hydrate (FE 200486 acetate hydrate) is a competitive and reversible gonadotropin-releasing hormone receptor (GnRHR/LHRHR) antagonist. Degarelix acetate hydrate can be used for prostate cancer research.
    Degarelix acetate hydrate
  • HY-105173
    Teverelix
    Teverelix (EP 24332) is a GnRH antagonist. Teverelix binds competitively and reversibly to GnRH receptors, thereby suppressing the release of LH and FSH. Teverelix can be used in the research of prostatic hyperplasia, endometriosis, and prostate cancer.
    Teverelix
  • HY-120767
    Linzagolix choline
    		Antagonist
    Linzagolix choline (KLH-2109 choline) is a non-peptide gonadotropin-releasing hormone (GnRH) antagonist with oral activity. Linzagolix choline inhibits the release of endogenous gonadotropins such as luteinizing hormone LH and follicle-stimulating hormone FSH by binding to the GnRH receptor within the pituitary gland. This inhibition results in a reduction in the production of sex hormones such as estrogen and progesterone, which in turn affects the course of sex hormone-dependent diseases. Linzagolix choline can be used in the study of sex hormone-dependent diseases such as endometriosis and uterine fibroids.
    Linzagolix choline
  • HY-P4564
    (D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH
    (D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH is an analogue of luteinizing hormone-releasing hormone (LHRH). LHRH plays a central role in the control of reproduction by stimulating the release of pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
    (D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH
  • HY-P3605
    GnRH Associated Peptide (25-53), human
    		Activator
    GnRH Associated Peptide (GAP) (25-53), human is the human gonadotropin-releasing hormone-associated peptide (GAP) 25-53 fragment (hGAP-25-53), can be used as immunogen to generate antiseras including MC-1, MC-2, and MC-3. GAP is joined to the luteinizing hormone-releasing hormone (LH-RH) sequence by a 3 amino acid processing site.
    GnRH Associated Peptide (25-53), human
  • HY-P2067
    Argtide
    		Antagonist
    Argtide is a luteinizing hormone-releasing hormone (LHRH) antagonist. Argtide is used in endometriosis and cancer-related research.
    Argtide
  • HY-P4688
    (Ser(Ac)4,D-Ser(tBu)6,Azagly10)-LHRH
    (Ser(Ac)4,D-Ser(tBu)6,Azagly10)-LHRH is an important peptide hormone.
    (Ser(Ac)4,D-Ser(tBu)6,Azagly10)-LHRH
  • HY-P3583
    (Des-Gly10,D-Arg6,Pro-NHEt9)-LHRH II (chicken)
    Des-Gly10,D-Arg6,Pro-NHEt9)-LHRH II (chicken) is an active petide. (Des-Gly10,D-Arg6,Pro-NHEt9)-LHRH II (chicken) can be used for the research of various biochemical studies.
    (Des-Gly10,D-Arg6,Pro-NHEt9)-LHRH II (chicken)
  • HY-P3975
    Glp-His-Pro-Gly-NH2
    		Agonist
    Glp-His-Pro-Gly-NH2 (pGlu-His-Pro-Gly-NH2) is a peptide containing 4 amino acids. Glp-His-Pro-Gly-NH2 stimulates gonadotrophin, luteinizing hormone (LH) and follicle stimulating hormone (FSH) release.
    Glp-His-Pro-Gly-NH2
  • HY-P4739
    LHRH (1-5) (free acid)
    LHRH (1-5) (free acid) is a polypeptide generated by the cleavage of LHRH at the Tyr55-Gly66 site. LHRH (1-5) (free acid) is converted into LHRH (1-3) and LHRH (4-5) fragments under the catalysis of Angiotensin-converting enzyme (HY-P2983).
    LHRH (1-5) (free acid)
Cat. No. Product Name / Synonyms Application Reactivity