Glucokinase

Hexokinase IV; Hexokinase D

Glucokinase

Related Products

Glucokinase is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Glucokinase occurs in cells in theliver, pancreas, gut, and brain of humans and most other vertebrates. In each of these organs it plays an important role in the regulation of carbohydrate metabolism by acting as a glucose sensor, triggering shifts in metabolism or cell function in response to rising or falling levels of glucose, such as occur after a meal or when fasting. Glucokinase has a lower affinity for glucose than the other hexokinases do, and its activity is localized to a few cell types, leaving the other three hexokinases as more important preparers of glucose for glycolysis and glycogen synthesis for most tissues and organs. Mutations of the gene for this enzyme can cause unusual forms of diabetes or hypoglycemia.

Glucokinase Related Products (33):

By Effects:	Inhibitors (2) Agonist (1) Activators (26) Modulators (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-15671A

GKA50 quarterhydrate	Activator	≥98.0%
GKA50 quarterhydrate is a potent glucokinase activator (EC₅₀=33 nM at 5 mM glucose) and stimulates insulin release from mouse islets of Langerhans. GKA50 quarterhydrate is a glucose-like activator of beta-cell metabolism in rodent and human islets and a Ca²⁺-dependent modulator of insulin secretion. GKA50 quarterhydrate shows significant glucose lowering in high fat fed female rats.

HY-117721

IHVR-11029	Inhibitor	99.83%
IHVR-11029 is a small molecule inhibitor of ER α-glucosidases, with an EC₅₀ of 0.09 μM.

HY-19843A

MK-0941 free base	Activator
MK-0941 free base is an orally active glucokinase activator, with EC₅₀s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 free base exhibits strong glucose-lowering activity and is a potential therapeutic agent for treatment of type 2 diabetes.

HY-133127A

AR453588 hydrochloride	Activator
AR453588 hydrochloride is a potent and orally bioavailable anti-diabetic glucokinase activator, with an EC₅₀ of 42 nM. AR453588 hydrochloride shows anti-hyperglycemic activity.

HY-101788

Glucokinase activator 1	Activator
Glucokinase activator 1 is a liver-directed glucokinase activator with an EC₅₀ of 34 nM.

HY-116946

Glucokinase activator 6	Activator
Glucokinase activator 6 (compound 9) is a potent glucokinase activator, with an EC₅₀ of 0.09 μM. Glucokinase activator 6 can be used for type 2 diabetes (T2D) research.

HY-117603

CM-10-18	Inhibitor
CM-10-18 is a potent and orally active inhibitor of both α-glucosidases I and II in vitro and in treated animals. CM-10-18 inhibits DENV infection of cultured human cells and reduces the peak viremia of DENV in mice.

HY-121070

AZD1092	Activator
AZD1092 is an orally active glucokinase (GK) activator with an EC₅₀ value of 0.03 μM. AZD1092 can be used for the research of Type 2 Diabetes (T2D).

HY-14747

Piragliatin	Activator
Piragliatin (RO4389620) is an activator for glucokinase, which reduces endogenous glucose production, increases β-cell function and glucose utilization, and thus decreases the blood glucose levels. Piragliatin exhibits antidiabetic efficacy.

HY-109030R

Dorzagliatin (Standard)	Activator
Dorzagliatin (Standard) is the analytical standard of Dorzagliatin. This product is intended for research and analytical applications. Dorzagliatin (HMS5552), a dual-acting glucokinase (GK) activator, improves glycaemic control and pancreatic β-cell function in type 2 diabetes.

HY-119813

(S,S)-Sinogliatin	Activator
(S,S)-Sinogliatin ((S,S)-HMS-5552) is the (S,S) -enantiomer of Sinogliatin. Sinogliatin is a glucokinase activator that can be used to study type 2 diabetes.

HY-116682

GKA-71	Activator
GKA-71 is an orally active Glucokinase activator, possesses an islet protective effect.

HY-U00411

PSN-GK1	Activator
PSN-GK1 is a potent glucokinase activator with an EC₅₀ of 0.13 μM.

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