2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Hexokinase
  5. Hexokinase Inhibitor

Hexokinase Inhibitor

Hexokinase Inhibitors (9):

Cat. No. Product Name Effect Purity
  • HY-13966
    2-Deoxy-D-glucose
    		Inhibitor 99.93%
    2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase.
  • HY-19992
    3-Bromopyruvic acid
    		Inhibitor ≥98.0%
    3-Bromopyruvate (Bromopyruvic acid) is an analogue of pyruvate and a potent hexokinase (HK)-II inhibitor with high tumor selectivity. 3-Bromopyruvate inhibits cell growth and induces apoptosis through interfering with glycolysis. 3-Bromopyruvate induces autophagy by stimulating ROS formation in breast cancer cells. Antimicrobial activities.
  • HY-B0486
    Lonidamine
    		Inhibitor 99.73%
    Lonidamine (AF-1890) is a hexokinase and mitochondrial pyruvate carrier inhibitor (Ki: 2.5 μM). Lonidamine also inhibits aerobic glycolysis in cancer cells. Lonidamine can be used in the research of mitochondrial metabolism and inflammation, such as pulmonary fibrosis.
  • HY-111331
    Germicidin B
    		Inhibitor
    Germicidin B is an antibiotic with bactericidal properties. Germicidin B can inhibit hexokinase II, with an IC50 of 25.16 μM.
  • HY-168717
    Antitumor agent-190
    		Inhibitor
    Antitumor agent-190 (Compound 26) is a Hexokinase 2 inhibitor that demonstrates significant anti-tumor activity by targeting microtubules and Hexokinase 2, with an IC50 value of 0.764 μM against MD-MBA-231 cells. Antitumor agent-190 effectively inhibits the activity of Hexokinase 2, leading to the accumulation of Reactive Oxygen Species and dysfunction of the mitochondrial membrane potential (MMP), thereby promoting apoptosis and blocking the cell cycle.
  • HY-13966S3
    2-Deoxy-D-glucose-13C6
    		Inhibitor
    2-Deoxy-D-glucose-13C6 (2-DG-13C6) is 13C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase.
  • HY-W000133
    Metrizamide
    		Inhibitor ≥99.0%
    Metrizamide (Amipaque) is used as the contrast medium for angiography in neuroradiological investigations. Metrizamide inhibits human brain hexokinase.
  • HY-P10108
    Hexokinase II VDAC binding domain peptide, cell-permeable
    		Inhibitor 98.37%
    Hexokinase II VDAC binding domain peptide (Hxk2VBD peptide) is a cell-permeable hexokinase II VDAC binding domain. Hexokinase II VDAC binding domain peptide inhibits mitochondrial localization of hexokinase 2 (HXK2). Hexokinase II VDAC binding domain peptide inhibits neurotrophic factor-directed axon outgrowth.
  • HY-B0486R
    Lonidamine (Standard)
    		Inhibitor
    Lonidamine (Standard) is the analytical standard of Lonidamine. This product is intended for research and analytical applications. Lonidamine (AF-1890) is a hexokinase and mitochondrial pyruvate carrier inhibitor (Ki: 2.5 μM). Lonidamine also inhibits aerobic glycolysis in cancer cells. Lonidamine can be used in the research of mitochondrial metabolism and inflammation, such as pulmonary fibrosis.