Kinesin

Related Products

Kinesins are a family of molecular motors that use the energy of ATP hydrolysis to move along the surface of, or destabilize, microtubule filaments. The kinesin motor protein family consists of 14 distinct subclasses and 45 kinesin proteins in humans. A large number of these proteins, or their orthologues, have been shown to possess essential function(s) in both the mitotic and the meiotic cell cycle. Kinesins also can be classified into three groups based on the position of their motor domains: N-terminal, C-terminal and internal kinesins. Conventional kinesin operates as a dimer, walking in a co-ordinated, hand-over-hand fashion along a microtubule protofilament.

Kinesins have important roles in chromosome separation, microtubule dynamics, spindle formation, cytokinesis and cell cycle progression. Roles of kinesins in diseases typically involve defective transport of cell components, transport of pathogens, or cell division.

Kinesin Isoform Specific Products:

Kinesin Isoform Comparison

Kinesin Related Products (74)
Antibodies (15)
Kinesin Isoform Comparison

By Effects:	Control (1) Inhibitors (67) Degrader (1) Activator (1) Modulator (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-132840

Sovilnesib	Inhibitor	99.89%
Sovilnesib (AMG 650) is a potent, orally active kinesin-like protein KIF18A inhibitor with an IC₅₀ value of 0.071 μM. Sovilnesib can be used for the research of cancer.

HY-50759

Ispinesib	Inhibitor	99.62%
Ispinesib is a specific inhibitor of kinesin spindle protein (KSP), with a K_{i app} of 1.7 nM.

HY-101071A

Monastrol	Inhibitor	99.89%
Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5 with an IC₅₀ value of 14 μM.

HY-10299

GSK-923295	Inhibitor	99.82%
GSK-923295 is a special, allosteric inhibitor of centromere-associated protein-E (CENP-E) kinesin motor ATPase activity, with K_i of 3.2±0.2 nM and 1.6± 0.1 nM for human and canine, respectively.

HY-15187

Filanesib	Inhibitor	98.23%
Filanesib (ARRY-520) is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC₅₀ of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. Filanesib has potent anti-proliferative activity.

HY-121569

Syntelin	Inhibitor	98.25%
Syntelin is a selective centromere protein E (CENP-E) inhibitor with IC₅₀ at 160 nM. Syntelin has antitumor activity.

HY-115570A

(Z/E)-GW406108X	Inhibitor
(Z/E)-GW406108X is a mixture of different configurations of GW406108X (HY-115570). GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC₅₀ of 0.82 uM.

HY-162937

KIF18A-IN-13	Inhibitor
KIF18A-IN-13 (Compound 16) is an effective and orally active inhibitor of KIF18A with anticancer activity in vivo. KIF18A-IN-13 can be utilized for research in ovarian cancer.

HY-12241

AZ82	Inhibitor	99.31%
AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor, with a K_i of 43 nM and an IC₅₀ of 300 nM for KIFC1.

HY-12069

SB-743921 hydrochloride	Inhibitor	99.87%
SB-743921 hydrochloride is a potent inhibitor of the mitotic kinesin KSP (Eg5), with a K_i of 0.1 nM.

HY-W011102

S-Trityl-L-cysteine	Inhibitor	99.10%
S-Trityl-L-cysteine (NSC 83265) is a selective and allosteric kinesin Eg5 inhibitor with an IC₅₀ of 1 μM for the inhibition of basal ATPase activity and 140 nM for the microtubule-activated ATPase activity. S-Trityl-L-cysteine has antitumor activities.

HY-14846

Litronesib	Inhibitor	99.59%
Litronesib (LY2523355) is a selective mitosis-specific kinesin Eg5 inhibitor, with antitumor activity.

HY-101770

BTB-1	Inhibitor	99.75%
BTB-1 is a potent, selective and reversible mitotic motor protein Kif18A inhibitor with an IC₅₀ of 1.69 μM.

HY-101298

Paprotrain	Inhibitor	99.87%
Paprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC₅₀ of 1.35 μM and a K_i of 3.36 μM and shows a moderate inhibition activity on DYRK1A with an IC₅₀ of 5.5 μM.

HY-19944

Dimethylenastron	Inhibitor	98.07%
Dimethylenastron is a potent kinesin Eg5 inhibitor, with an IC₅₀ of 200 nM.

HY-153065

KIF18A-IN-6	Inhibitor	98.56%
KIF18A-IN-6 (Compound 134) is an orally active KIF18A inhibitor with an IC₅₀ of 0.016 μM against KIF18A microtubule-dependent ATPase activity.

HY-144894

AM-5308	Inhibitor	99.26%
AM-5308 is a potent kinesin KIF18A inhibitor (WO2021211549A1, C13).

HY-15000

EMD534085	Inhibitor	99.55%
EMD534085 is a potent and selective inhibitor of the mitotic kinesin-5 with an IC₅₀ of 8 nM.

HY-15948

Kif15-IN-1	Inhibitor	99.39%
Kif15-IN-1 is an inhibitor of the mitotic Kinesin family member 15 (Kif15), and is used for the research of cellular proliferative diseases.

HY-115570

GW406108X	Inhibitor	≥98.0%
GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC₅₀ of 0.82 uM in ATPase assays. GW406108X, a potent autophagy inhibitor, shows ATP competitive inhibition against ULK1 with a pIC₅₀ of 6.37 (427 nM). GW406108X inhibits ULK1 kinase activity and blocks autophagic flux, without affecting the upstream signaling kinases mTORC1 and AMPK.

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Kinesin

Kinesin

Kinesin Isoform Specific Products:

Kinesin Isoform Specific Products:

Kinesin Related Products (74)

Antibodies (15)

Kinesin Isoform Comparison

Kinesin Related Products (74):