2. Signaling Pathways
  3. Neuronal Signaling
  4. Legumain

Legumain

Asparaginyl endopeptidase; δ-secretase

Legumain is also known as asparaginyl endopeptidase or δ-secretase. Legumain is a family of cysteine proteases that specifically cleave peptide bonds at their carboxyl-terminal side of Asn or Asp residues. In plants, Legumains are key enzymes in the processing and activation of seed storage proteins during seed maturation. In mammals, Legumain mainly plays its protease activity. Legumain facilitates haemoglobin digestion. Legumain is also involved in processing self and foreign proteins for presentation on the MHCII complex. Besides, Legumain takes part in osteoclast remodeling. Legumain has broad tissue distribution, and is highly expressed in the kidneys, placenta, spleen, bladder, lungs, and thyroid and lymph nodes. Legumain is also overexpressed in cancers and promotes cancer cell migration[1][2].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-112205A
    RR-11a analog
    		Inhibitor 99.12%
    RR-11a analog is a potent and irreversible inhibitor of Schistosoma mansoni legumain, with an IC50 of 31 nM. RR-11a analog is an aza-Asn derivative and aza-peptide Michael acceptor.
    RR-11a analog
  • HY-128617
    Legumain inhibitor 1
    		Inhibitor 98.14%
    Legumain inhibitor 1 is a potent and selective Legumain inhibitor with an IC50 of 3.6 nM. Legumain inhibitor 1 can be used for cancer research.
    Legumain inhibitor 1
  • HY-112205
    RR-11a
    		Inhibitor
    RR-11a is a synthetic enzyme inhibitor of Legumain (IC50=31-55 nM). RR-11a can be used for the research of cancer and acute myocardial infarction (AMI).
    RR-11a
  • HY-149102
    LE 28
    LE 28 is a selective and activity-dependent legumain probe. LE 28 becomes fluorescent only upon binding active legumain. LE 28 can be used for research of cancers and inflammatory diseases.
    LE 28
Cat. No. Product Name / Synonyms Application Reactivity