Liposome

Liposomes (NPs typically 100–500 nm in diameter) are fabricated from the self-assembly of phospholipids, which consist of a polar phosphate head group and hydrophobic lipid tails. In aqueous environments, the hydrophobic tails self-orient, resulting in a spherical structure comprised of an aqueous core surrounded by a lipophilic bilayer membrane. Liposomes are both biocompatible and biodegradable (e.g., at certain pH and temperature), which can be controlled by modifying the lipid composition. Furthermore, liposomes are amenable to various modifications that improve their efficacy as drug delivery carriers.

References:

[1]. Almeida B, Nag OK, Rogers KE, Delehanty JB. Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery. Molecules. 2020;25(23):5672. Published 2020 Dec 1. [Content Brief]

Liposome Related Products (730):

By Effects:	Control (1) Inhibitor (1) Modulator (1) Chemicals (8)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-112764A

DMG-PEG (Excipient)		99.98%
DMG-PEG Excipient is used?for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG Excipient is also used for the?lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles.

HY-159713

Lipid R6
Lipid R6 is a lipid molecule that can be used to synthesize liposomes and is the lipid component in lipid nanoparticle (LNP) systems.

HY-W440820

Bis(bis(2-carboxyethyl)aminopropyl)methylamine
Bis(bis(2-carboxyethyl)aminopropyl)methylamine is a symmetrical branched linker featuring three tertiary amines and four carboxylic acids. Each carboxylic acid is open to forming esters or amides. It can be used in developing lipid nanoparticles.

HY-165156

DPPE-MPEG (2000)
DPPE-MPEG 2000 (1,2-DPPE-MPEG(2000)) is a PEG-modified lipids. DPPE-MPEG 2000 can reduce the nonspecific adsorption of protein and prolong circulation time in vivo.

HY-171170

18:0-LPS
18:0-LPS (Lysophosphatidylserine C18:0) is an endogenous lipid, which is found during the oxidation of phospholipids. 18:0-LPS is promising for research of cardiovascular diseases.

HY-157270

2-Heptylundecanol
2-Heptylundecanol is a branched chain aliphatic alcohol which can be used in the synthesis of nano lipid particles.

HY-143209B

DSPE-PEG3400
DSPE-PEG3400 is a phospholipids-polymer conjugate that can be used in drug delivery applications. DSPE-PEG3400 is a material for the formulation of nanocarriers for achieving prolonged blood circulation time, improved stability and enhanced encapsulation efficiency.

HY-168777

Lipid 7-1
Lipid 7-1 is an ionizable cationic lipid that can be used for the preparation of liposomes.

HY-159866

mPEG2000-CLS
mPEG2000-CLS (mPEG2000-Cholesterol) is a PEGylated form of Cholesterol (HY-N0322). mPEG2000-CLS can be used to prepare liposome or nanoparticle.

HY-160256

DSPE-PEG-BDP FL,MW 2000
DSPE-PEG-BDP FL,MW 2000 is a PEG lipid, composed of a DSPE phospholipid and a BDP FL dye.

HY-159860

IR-117-17
IR-117-17 is an ionizable cationic amino lipid, targeting the conducting airways. IR-117-17 could be degraded via esterase cleavage and thus be unlikely to accumulate upon repeated dosing.

HY-D2517

Cy3-PEG-DSPE (MW 5000)
Cy3-PEG-DSPE (MW 5000) is a PEG phospholipid with Cy3 (HY-D0822) dye used in protein/nucelic acid labeling. Cy3-PEG-DSPE (MW 5000) can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.

HY-D2516

Cy3-PEG-DSPE (MW 3400)
Cy3-PEG-DSPE (MW 3400) is a PEG phospholipid with Cy3 (HY-D0822) dye used in protein/nucelic acid labeling and fluorescence microscopy. Cy3-PEG-DSPE (MW 3400) can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.

HY-W440936

Stearic acid-PEG-Rhodamine, MW 5000
Stearic acid-PEG-Rhodamine, MW 5000 is a fatty acid containing PEG polymer which can self assemble in an aqueous solution to form micelles. The polymer can be used to prepare nanoparticles for drug encapsulation. The red dye rhodamine can be easily traced by fluorescence microscopy. Rhodamine has maximum absorption at 570 nm and emission around 595 nm.

HY-W440934

Stearic acid-PEG-Rhodamine, MW 2000
Stearic acid-PEG-Rhodamine, MW 2000 is an amphiphilic PEG polymer which can form micelles in water. The rhodamine can be used for staining sample and easily traced by fluorescence microscopy. Rhodamine has maximum absorption at 570 nm and emission around 595 nm.

HY-159869

G0-C14 analog
G0-C14 analog is a G0-C14 derivative. G0-C14 is an ionizable cationic lipid that can be used to synthesize lipid nanoparticles (LNP).

HY-B1555R

Benzyl nicotinate (Standard)
Benzyl nicotinate (Standard) is the analytical standard of Benzyl nicotinate. This product is intended for research and analytical applications. Benzyl nicotinate is a vasodilator that increases skin oxygenation levels by increasing skin blood flow.

HY-164579

NH2-GG-DSPE
NH2-GG-DSPE is a lipid compound that can be used for liposome preparation. Liposomes are the main component of vesicles with concentric phospholipid bilayer membranes, which can be used to construct drug delivery systems for anti-cancer and anti-infection fields. Highly polar water-soluble loads can be captured in the internal aqueous space of liposomes, while lipophilic loads can be distributed into the lipid bilayer and become part of the lipid bilayer. Especially for the delivery of antisense oligonucleotides, it can overcome the problems of inefficient cellular uptake and rapid loss in the body.

HY-155925

DMPE-PEG550
DMPE-PEG550 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-172017

CP-LC-1254
CP-LC-1254 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA).

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