2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Melanocortin Receptor

Melanocortin Receptor

MC Receptor

Melanocortin Receptor

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The melanocortin (MC) receptors represent a subfamily of G-protein-coupled receptors (GPCRs) where the different subtypes are involved in a wide range of physiological functions such as pigmentation, steroid secretion, energy homeostasis, and food intake. The melanocortin receptor (MCR) family consists of five G-protein-coupled receptors (MC1R-MC5R). MC1R controls pigmentation, MC2R is a critical component of the hypothalamic-pituitary-adrenal axis, MC3R and MC4R have a vital role in energy homeostasis and MC5R is involved in exocrine function.

MCRs are activated by a variety of neuropeptides, termed melanocortins, that include the adrenocorticotropic hormone (ACTH) andα, β and γ-melanocyte-stimulating hormones (MSHs). Melanocortins derive from post-translational processing of the common polypeptide precursor pro-opiomelanocortin, expressed mainly in the hypothalamus and pituitary.

Melanocortin Receptor Isoform Specific Products:

Melanocortin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-RS08201
    Mc1r Mouse Pre-designed siRNA Set A
    		Inhibitor

    Mc1r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mc1r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mc1r Mouse Pre-designed siRNA Set A
    Mc1r Mouse Pre-designed siRNA Set A
  • HY-RS08214
    Mc5r Rat Pre-designed siRNA Set A
    		Inhibitor

    Mc5r Rat Pre-designed siRNA Set A contains three designed siRNAs for Mc5r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mc5r Rat Pre-designed siRNA Set A
    Mc5r Rat Pre-designed siRNA Set A
  • HY-RS08203
    MC2R Human Pre-designed siRNA Set A
    		Inhibitor

    MC2R Human Pre-designed siRNA Set A contains three designed siRNAs for MC2R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    MC2R Human Pre-designed siRNA Set A
    MC2R Human Pre-designed siRNA Set A
  • HY-P3977
    ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat)
    ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) is the 3-24 fragment of adrenocorticotropic hormone (ACTH). ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) can be used for research of a variety of diseases, including cancer, immune diseases, cardiovascular disease.
    ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat)
  • HY-P1214A
    γ1-MSH TFA
    		Agonist
    γ1-MSH TFA is a melanocortin MC3 receptor agonist, with a Ki of 34 nM for the rat MC3 receptor. γ1-MSH TFA displays ~40-fold selectivity over MC4 (Ki=1318 nM).
    γ1-MSH TFA
  • HY-119808
    Terrein
    		Inhibitor
    Terrein is a melanogenesis inhibitor. Terrein induces apoptosis in breast cancer cell lines . Terrein is an inhibitor of quorum sensing and c-di-GMP in Pseudomonas aeruginosa.
    Terrein
  • HY-P10571
    GPS1573
    		Antagonist
    GPS1573 is a noncompetitive antagonist of melanocortin type 2 receptor (MC2R) that dose-dependently antagonizes ACTH-stimulated MC2R activity (IC50=66 nM). GPS1573 can be used in the study of Cushing's disease due to its highly selective antagonism of MC2R.
    GPS1573
  • HY-RS08211
    Mc4r Rat Pre-designed siRNA Set A
    		Inhibitor

    Mc4r Rat Pre-designed siRNA Set A contains three designed siRNAs for Mc4r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mc4r Rat Pre-designed siRNA Set A
    Mc4r Rat Pre-designed siRNA Set A
  • HY-19648
    Ebiratide
    Ebiratide (HOE-427 free base) is an ACTH 4-9 derivative, which acts directly on the central nervous system and exhibits memory-enhancing efficacy. Ebiratide enhances acetycholine (ACh) metabolism in rat brain.
    Ebiratide
  • HY-P1726A
    MSG606 TFA
    		Antagonist
    MSG606 TFA is a potent human MC1 receptor antagonist (IC50=17 nM). MSG606 TFA also partial agonist at human MC3 and MC5 receptors (EC50 values are 59 and 1300 nM, respectively). MSG606 TFA exhibits binding affinity for A375 melanoma cells in vitro. MSG606 TFA reverses the induced hyperalgesia in female mice, with no effect in male mice.
    MSG606 TFA
  • HY-RS08207
    Mc3r Mouse Pre-designed siRNA Set A
    		Inhibitor

    Mc3r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mc3r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mc3r Mouse Pre-designed siRNA Set A
    Mc3r Mouse Pre-designed siRNA Set A
  • HY-18678
    Bremelanotide
    Bremelanotide (PT-141) is an analogue of α-melanocyte-stimulating hormone (α-MSH). Bremelanotide activates the mPOA and other hypothalamic and limbic regions of the brain involved in sexual behavior. Bremelanotide can be used for researching hypoactive sexual desire disorders.
    Bremelanotide
  • HY-153660A
    Bivamelagon hydrochloride
    		Agonist
    MC-4R Agonist 2 hydrochloride (Example 1) is a MC4R agonist. MC-4R Agonist 2 hydrochloride can be used in the study of obesity, diabetes, inflammation, and erectile dysfunction.
    Bivamelagon hydrochloride
  • HY-W267446
    6-Methoxy-4-methylcoumarin
    		Activator
    6-Methoxy-4-methylcoumarin is a 4-methylcoumarin derivative with an antitumor activity. 6-Methoxy-4-methylcoumarin activates melanin synthesis in B16F10 melanoma cells. 6-Methoxy-4-methylcoumarin is a pigmentation stimulator, and can be used for the study of skin conditions such as vitiligo.
    6-Methoxy-4-methylcoumarin
  • HY-N13879
    Amphistin
    		Inhibitor
    Amphistin is a melanogenesis inhibitor found in actinomycete. Amphistin inhibits the melanogenesis of B16 melanoma cells without affecting the growth of the cell.
    Amphistin
  • HY-N14938
    Albocycline K3
    		Inhibitor
    Albocycline K3 is a melanogenesis inhibitor of microbial origin.
    Albocycline K3
  • HY-W738639
    18-Hydroxy-11-deoxy corticosterone
    18-Hydroxy-11-deoxy corticosterone (18-OH-DOC) is a mineralocorticoid whose synthesis is regulated by adrenocorticotropic hormone (ACTH) and angiotensin II. 18-Hydroxy-11-deoxy corticosterone is an intermediate in the metabolism of progesterone and plays an important role in regulating blood pressure and water-salt balance. Continuous infusion of 18-Hydroxy-11-deoxy corticosterone can increase systolic blood pressure in rats, and plasma levels of 18-Hydroxy-11-deoxy corticosterone are significantly elevated in the db/db mouse model of type 2 diabetes, suggesting its potential involvement in metabolic dysregulation and diabetes-related regulation. 18-Hydroxy-11-deoxy corticosterone holds promise for research in areas such as hypertension, diabetes, and other related fields.
    18-Hydroxy-11-deoxy corticosterone
  • HY-B1456AR
    Fenoprofen (Standard)
    		Agonist
    Fenoprofen (Standard) is the analytical standard of Fenoprofen. This product is intended for research and analytical applications. Fenoprofen (LILLY-53858) is a nonsteroidal anti-inflammatory agent (NSAID). Fenoprofen can be used to to relieve symptoms of arthritis (osteoarthritis and rheumatoid arthritis), such as inflammation, swelling, stiffness, and joint pain. Fenoprofen is an allosteric enhancer for melanocortin receptors. Fenoprofen also increases ERK1/2 activation.
    Fenoprofen (Standard)
  • HY-159909
    ATMW-2
    		Inhibitor
    ATMW-2 is a NeuralGenThesis (NGT)-derived antagonist targeting the melanocortin type 2 receptor (MC2R).
    ATMW-2
  • HY-147301B
    Resomelagon methanesulfonate
    		Agonist
    Resomelagon methanesulfonate (AP1189 methanesulfonate) is the methanesulfonate salt form of Resomelagon (HY-147301). Resomelagon methanesulfonate is an orally active melanocortin receptor (MR) agonist. Resomelagon methanesulfonate induces ERK1/2 phosphorylation and Ca2+ mobilization. Resomelagon methanesulfonate exhibits anti-inflammatory activity in mouse peritonitis and peritonitis model. Resomelagon methanesulfonate can be used for obesity and chronic inflammation research.
    Resomelagon methanesulfonate
Cat. No. Product Name / Synonyms Application Reactivity
Melanocortin Receptor Isoform Comparison

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