2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Neprilysin

Neprilysin

Neutral endopeptidase; NEP; Cluster of differentiation 10; CD10

Neprilysin

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Neprilysin (NEP) is a type II membrane metalloendopeptidase composed of ∼750 residues with an active site containing a zinc-binding motif (HEXXH) at the extracellular carboxyl terminal domain. Neprilysin is capable of degrading the monomeric and the oligomeric forms of Aβ peptide. Neprilysin is the dominant Aβ peptide-degrading enzyme in the brain; Neprilysin becomes inactivated and down-regulated during both the early stages of Alzheimer’s disease (AD) and aging.

Neprilysin is a neutral endopeptidase and its inhibition increases bioavailability of natriuretic peptides, bradykinin, and substance P, resulting in natriuretic, vasodilatatory, and anti-proliferative effects.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-15407AS1
    Sacubitril-d4 hemicalcium salt
    		Inhibitor 98.78%
    Sacubitril-d4 hemicalcium salt is the deuterium labeled Sacubitril hemicalcium salt (HY-15407A). Sacubitril hemicalcium salt is a potent NEP inhibitor with an IC50 of 5 nM.
    Sacubitril-d<sub>4</sub> hemicalcium salt
  • HY-17620S
    Sacubitrilat-d4
    		Inhibitor 99.28%
    Sacubitrilat-d4 is the deuterium labeled Sacubitrilat. Sacubitrilat (Desethyl Sacubitril) is an active neprilysin (NEP) inhibitor[1].
    Sacubitrilat-d<sub>4</sub>
  • HY-19876
    PL37
    		Antagonist
    PL37 (Debio-0827) is an orally active Enkephalinase dual inhibitor (dual inhibition refers to the simultaneous inhibition of Neutral Endopeptidase and Aminopeptidase N activities). PL37 exerts its anti-hyperalgesic effects by activating μ-opioid receptors (µ-opioid receptors), with an ED50 value of 13.4 mg/kg for analgesic effects in mice. PL37 can be used to study diabetic neuropathic pain.
    PL37
  • HY-17399S
    Racecadotril-d5
    		Inhibitor
    Racecadotril-d5 is the deuterium labeled Racecadotril. Racecadotril (Acetorphan) is a neutral endopeptidase (NEP) inhibitor. Racecadotril and its active metabolite Thiorphan inhibits purified NEP activity from mouse brain with Kis of 4500 and 6.1 nM, , respectively. Antidiarrheal agent[1].
    Racecadotril-d<sub>5</sub>
  • HY-116476
    Risotilide
    		Inhibitor
    Risotilide is an inhibitor of enkephalinase B, which has the ability to inhibit enkephalinase B activity (IC50 value is 0.35 microM), and can also effectively inhibit enkephalinase A (IC50 = 0.02 microM) and aminopeptidase activity (IC50 = 13 microM), and can be regarded as a complete inhibitor of enkephalin biodegradation.
    Risotilide
  • HY-W013375S
    Thiorphan-d7
    Thiorphan-d7 is the deuterium labeled Thiorphan[1]. Thiorphan is a selective NEP (neprilysin) inhibitor with an IC50 of 6.9 nM[2].
    Thiorphan-d<sub>7</sub>
  • HY-P2658
    [Des-Tyr1]-Met-Enkephalin
    [Des-Tyr1]-Met-Enkephalin, a tetrapeptide, is a degradationproduct of enkephalins.
    [Des-Tyr1]-Met-Enkephalin
  • HY-121796
    Mixanpril
    		Inhibitor
    Mixanpril is a compound with the ability to modulate insulin sensitivity and has the activity of regulating insulin sensitivity and femoral blood flow in obese Zucker rats. Mixanpril can affect insulin-mediated glucose disposal in obese Zucker rats and also has a regulatory effect on femoral blood flow, with different effects compared to the ACE inhibitor captopril.
    Mixanpril
  • HY-15407S3
    Sacubitril-13C4
    		Inhibitor
    Sacubitril-13C4 (AHU-377-13C4) is a 13C-labeled version of Sacubitril (HY-15407). Sacubitril is an orally active inhibitor of neprilysin NEP (IC50=5 nM). Sacubitril is used in research on heart failure, hypertension and COVID-19.
    Sacubitril-<sup>13</sup>C<sub>4</sub>
  • HY-114657
    Benproperine
    		Inhibitor
    Benproperine is a new neprilysin B inhibitor composed of N-acyl-L-prolyl-L-valine, whose N-acyl moiety is α-isobutylsuccinic acid β-hydroxamic acid.
    Benproperine
  • HY-15407BR
    Sacubitril (sodium) (Standard)
    		Inhibitor
    Sacubitril (sodium) (Standard) is the analytical standard of Sacubitril (sodium). This product is intended for research and analytical applications. Sacubitril sodium is a potent and orally active NEP (neprilysin) inhibitor, with an IC50 of 5 nM. Sacubitril sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril sodium is a component of the heart failure medicine LCZ696. Sacubitril sodium can be used for the research of heart failure, hypertension and COVID-19.
    Sacubitril (sodium) (Standard)
  • HY-10827
    Kelatorphan
    		Inhibitor 99.57%
    Kelatorphan is a full inhibitor of enkephalin degrading enzymes.
    Kelatorphan
  • HY-N2021AR
    Phosphoramidon (Disodium) (Standard)
    		Inhibitor
    Indole-3-butyric acid (Standard) is the analytical standard of Indole-3-butyric acid. This product is intended for research and analytical applications. Indole-3-butyric acid (3-indolebutyric acid) is a plant growth auxin and a good rooting agent. It can promote herbs and woody ornamental plant rooting and used for improving fruit rate. Indole 3-butyric acid is an auxin precursor, and is converted to indole 3-acetic acid (IAA) in a peroxisomal β-oxidation process.
    Phosphoramidon (Disodium) (Standard)
  • HY-139803
    SCH-39370
    SCH-39370 is a potent and specific inhibitor of neutral metalloendopeptidase (NEP) from rabbit kidney with an IC50 value of 11.2 nM. SCH-39370 potentiates biological responses to atrial natriuretic factor and lowers blood pressure in desoxycorticosterone acetate-sodium hypertensive rats.
    SCH-39370
  • HY-106975
    SCH-42354
    		Inhibitor
    SCH-42354 is a potent, orally active neutral endopeptidase (NEP) inhibitor, is the pharmacologically active form of the proagent SCH-42495. SCH-42354 inhibits the hydrolysis of NEP to enhance the activity of atrial natriuretic peptide (ANP). SCH-42354 inhibits hydrolysis of leu-enkephalin and ANF with IC50 values of 8.3 nM and 10.0 nM, respectively. SCH-42354 has antihypertensive activity.
    SCH-42354
  • HY-W013375S1
    Thiorphan-d5
    Thiorphan-d5 is deuterium labeled Thiorphan.
    Thiorphan-d<sub>5</sub>
  • HY-123782
    (Rac)-UK-414495
    		Inhibitor
    (Rac)-UK-414495 (example 7) is a potent neutral endopeptidase (NEP) inhibitor. (Rac)-UK-414495 causes potentiation of cAMP in the sexual genitalia of the female.
    (Rac)-UK-414495
  • HY-15407AS
    Sacubitril-13C4 hemicalcium salt
    		Inhibitor
    Sacubitril-13C4 (hemicalcium salt) is a 13C-labeled and deuterium labeled Sacubitril hemicalcium salt. Sacubitril (AHU-377) hemicalcium salt is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril hemicalcium salt is a component of the heart failure medicine LCZ696[1].
    Sacubitril-<sup>13</sup>C<sub>4</sub> hemicalcium salt
  • HY-101682B
    (R)-SCH 42495
    		Inhibitor
    (R)-SCH 42495 is the less active enantiomer of SCH 42495. SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester proagent of SCH 42354.
    (R)-SCH 42495
  • HY-N2021
    Phosphoramidon
    		Inhibitor
    Phosphoramidon, a microbial metabolite, is a specific metalloprotease thermolysin inhibitor with an IC50 of 0.4 μg/mL. Phosphoramidon also inhibits endothelin-converting enzyme (ECE), neutral endopeptidase (NEP), and angiotensin-converting enzyme (ACE) with IC50 values of 3.5, 0.034, and 78 μM, respectively.
    Phosphoramidon
Cat. No. Product Name / Synonyms Species Source