Others Inhibitor

Others Inhibitors (211):

Cat. No.	Product Name	Effect	Purity

HY-129389

Benzyl-α-GalNAc	Inhibitor	99.95%
Benzyl-α-GalNAc is a potent O-glycosylation inhibitor. Benzyl-α-GalNAc effectively inhibits the proliferation and activation of LX-2 cells and suppresses the expression of collagen I/III, which has good potential for investigation in liver fibrosis. Benzyl-α-GalNAc also significantly enhances the anti-tumour activity of 5-FU (HY-90006) (e.g. pancreatic cancer) by inhibiting O-glycosylation.

HY-W010342

6-Aminonicotinamide	Inhibitor	99.95%
6-Aminonicotinamide, a potent antimetabolite of nicotinamide, is competitive NADP⁺-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) inhibitor (K_i=0.46 μM). 6-Aminonicotinamide resultis ATP depletion and synergizes with DNA-crosslinking chemotherapy agents, such as Cisplatin, in killing cancer cells.

HY-107410

SC-26196	Inhibitor	99.68%
SC-26196 is a potent, orally active Delta6 desaturase (D6D, FADS2) inhibitor (IC₅₀=0.2 μM in a rat liver microsomal assay). Antiinflammatory properties.

HY-148335

IRG1-IN-1	Inhibitor	99.82%
IRG1-IN-1 is an itaconic acid derivative. IRG1-IN-1 can inhibit immune-responsive gene 1 (IRG1) activity. IRG1-IN-1 can be used for the research of cancer, inflammation and autoimmune diseases.

HY-108467

GGsTop	Inhibitor	99.35%
GGsTop (Nahlsgen) is a potent, non-toxic, highly selective and irreversible γ-GGT inhibitor, with a K_i of 170 μM for Human GGT. GGsTop shows a pK_a of 9.71, also exhibits K_ons of 150 and 51 M^-1 s^-1 against E.coli GGT and human GGT, respectively. GGsTop protects hepatic ischemia-reperfusion injury in rat model.

HY-14885

Eliglustat	Inhibitor	99.95%
Eliglustat is an specific, potent and orally active glucocerebroside synthase inhibitor with an IC₅₀ of 24 nM.

HY-146064

OPN expression inhibitor 1	Inhibitor
OPN expression inhibitor 1 (Compound 11) is an osteopontin (OPN) expression inhibitor. OPN expression inhibitor 1 can be used for breast cancer research.

HY-B0404A

Benserazide hydrochloride	Inhibitor	99.87%
Benserazide hydrochloride (Serazide) is commonly used in Parkinson's disease and is an inhibitor of peripheral aromatic L-amino acid decarboxylase (AADC).

HY-142114

SRI-37330	Inhibitor	98.76%
SRI-37330 is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. SRI-37330 inhibits glucagon secretion and function, reduces hepatic glucose production and reverses hepatic steatosis. SRI-37330 can be used for type 2 diabetes research.

HY-18681

Voxelotor	Inhibitor	99.99%
Voxelotor (GBT 440) is a potent inhibitor of haemoglobin S (HbS) polymerization. Voxelotor has the potential for sickle cell disease (SCD) treatment.

HY-18630A

Ro 48-8071 fumarate	Inhibitor	99.42%
Ro 48-8071 fumarate is an inhibitor of OSC (Oxidosqualene cyclase) with IC₅₀ of appr 6.5 nM.

HY-14929A

Migalastat hydrochloride	Inhibitor	99.70%
Migalastat (GR181413A free base) hydrochloride is an orally active α-galactosidase A molecular chaperone, with an IC₅₀ value of 0.04 μM for human α-Gal A. Migalastat binds to the active site of certain unstable mutant forms of α-galactosidase A, facilitating their transport to the lysosome. After dissociation in the acidic environment, Migalastat enables the mutant α-galactosidase A to exhibit biological activity.

HY-13746B

Sardomozide dihydrochloride	Inhibitor	99.76%
Sardomozide dihydrochloride is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC₅₀ of 5 nM.

HY-12837

EN460	Inhibitor	99.73%
EN460 is a selective endoplasmic reticulum oxidation 1 (ERO1) inhibitor. EN460 (IC₅₀ of 1.9 μM) interacts selectively with the reduced, active form of ERO1α and prevents its reoxidation.

HY-101464

ML329	Inhibitor	≥98.0%
ML329 is a micropthalmia-associated transcription factor (MITF) inhibitor, which inhibits TRPM-1 promoter activity with an IC₅₀ of 1.2 μM.

HY-16693

LDN-27219	Inhibitor	99.64%
LDN-27219 is a reversible, slow-binding inhibitor of TGase. LDN-27219 inhibits human TGase with an IC₅₀ value of 0.6 μM. LDN-27219 effectively decreases blood pressure and induces vasodilation, it can be used for the research of cardiovascular disease.

HY-132868

SLK/STK10-IN-1	Inhibitor	99.34%
SLK/STK10-IN-1 is a potent and selective inhibitor of SLK and STK10 with nanomolar potency.

HY-17469

Gimeracil	Inhibitor	99.72%
Gimeracil, a component of an oral fluoropyrimidine derivative S-1, inhibits DNA DSB repair and is a potent inhibitor of DPYD (dihydropyrimidine dehydrogenase, DPD).

HY-101144

RSM-932A	Inhibitor	98.44%
RSM-932A (TCD-717) is a specific ChoKα inhibitor with IC₅₀s of 1 and 33 μM for human recombinant ChoKα and ChoKβ enzymes, respectively. RSM-932A acts as the “first in humans” compound targeting ChoKα. RSM-932A is potent in vitro anti-proliferative and in vivo anti-tumoral activity against human xenografts in mice, showing high efficacy with low toxicity profiles.

HY-14885A

Eliglustat hemitartrate	Inhibitor	99.83%
Eliglustat hemitartrate is an specific, potent and orally active glucocerebroside synthase inhibitor with an IC₅₀ of 24 nM.

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