2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers
  5. PROTAC Linkers Isoform

PROTAC Linkers

 

PROTAC Linkers Related Products (179):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W021401
    Amino-PEG3-C2-Azido 134179-38-7 99.67%
    Amino-PEG3-C2-Azido is a PEG-based PROTAC linker can be used in the synthesis of the PARP1 degrader iRucaparib-TP3 (HY-130645). Amino-PEG3-C2-Azido is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Amino-PEG3-C2-Azido
  • HY-W008574A
    TGN-020 sodium 1313731-99-5 99.99%
    TGN-020 sodium is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 μM. TGN-020 sodium is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. TGN-020 sodium alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats.
    TGN-020 sodium
  • HY-W007803
    Boc-NH-C4-Br 164365-88-2 ≥98.0%
    Boc-NH-C4-Br is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-C4-Br
  • HY-108374
    4-Azidobutylamine 88192-20-5 ≥98.0%
    4-Azidobutylamine is a PROTAC linker, which refers to the alkyl chain composition. 4-Azidobutylamine can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. 4-Azidobutylamine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    4-Azidobutylamine
  • HY-130653
    Azido-PEG4-C2-acid 1257063-35-6 ≥98.0%
    Azido-PEG4-C2-acid a PEG-based PROTAC linker can be used in the synthesis of vRucaparib-TP4. Azido-PEG4-C2-acid is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG4-C2-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-C2-acid
  • HY-W248248
    tert-Butyl 9-aminononanoate 134857-22-0 ≥98.0%
    tert-Butyl 9-aminononanoate is a PROTAC linker. tert-Butyl 9-aminononanoate can be used in synthesis PROTAC sEH-degrader-1 (HY-159494).
    tert-Butyl 9-aminononanoate
  • HY-W003696
    tert-Butyl 5-bromoisoindoline-2-carboxylate 201940-08-1 98.89%
    tert-Butyl 5-bromoisoindoline-2-carboxylate is a PROTAC Linker. tert-Butyl 5-bromoisoindoline-2-carboxylate can be used in synthesis PTOTAC HSD17B13 degrader 1 (HY-159651).
    tert-Butyl 5-bromoisoindoline-2-carboxylate
  • HY-W006635
    Bpin-Cyclohexene-COOEt 1049004-32-1
    Bpin-Cyclohexene-COOEt (Ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-cyclohexene-1-carboxylate) is a PROTAC linker belonging to the PEG class. Bpin-Cyclohexene-COOEt can be used to synthesize PROTAC molecules.
    Bpin-Cyclohexene-COOEt
  • HY-W015088
    Amino-PEG3-C2-Amine 929-75-9 99.32%
    Amino-PEG3-C2-Amine is a PEG-based (3 units) PROTAC linker can be used in the synthesis of PROTACs.
    Amino-PEG3-C2-Amine
  • HY-W092043
    TLR4-IN-C34-C2-COOH 1159408-54-4
    TLR4-IN-C34-C2-COO is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.
    TLR4-IN-C34-C2-COOH
  • HY-130659
    Amino-PEG8-amine 82209-36-7 ≥98.0%
    Amino-PEG8-amine is a PEG-based (8 units) PROTAC linker can be used in the synthesis of PROTACs.
    Amino-PEG8-amine
  • HY-W008296
    NH2-C6-NH-Boc 51857-17-1 99.61%
    NH2-C6-NH-Boc is a PROTAC linker which refers to the alkyl/ether composition. NH2-C6-NH-Boc can be used in the synthesis the Mcl-1 inhibitor based on PROTAC.
    NH2-C6-NH-Boc
  • HY-136158A
    6-Maleimidocaproic acid sulfo-NHS sodium 215312-86-0 98.91%
    6-Maleimidocaproic acid sulfo-NHS (Sulfo-EMCS) sodium is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    6-Maleimidocaproic acid sulfo-NHS sodium
  • HY-124323
    m-PEG4-NHS ester 622405-78-1
    m-PEG4-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG4-NHS ester
  • HY-W190796A
    Mal-PEG3-NH2 TFA 2830214-77-0 98.93%
    Mal-PEG3-NH2 TFA is a linear heterobifunctional PEG crosslinker with Maleimide (HY-W007324) and amine. Mal-PEG3-NH2 TFA is a non-degradable (non-cleavable) PROTAC linker.
    Mal-PEG3-NH2 TFA
  • HY-130871A
    HS-PEG3-CH2CH2NH2 hydrochloride
    HS-PEG3-CH2CH2NH2 hydrochloride (Thiol-PEG3-amine hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    HS-PEG3-CH2CH2NH2 hydrochloride
  • HY-140656A
    Biotin-PEG-Biotin 194920-55-3
    Biotin-PEG-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG-Biotin
  • HY-W013249
    Boc-piperazine-benzoic acid 162046-66-4
    Boc-piperazine-benzoic acid is a PROTAC linker and can be used in the synthesis of PROTACs, such as PROTAC androgen receptor (AR) degrader ARD-2128 (HY-13229).
    Boc-piperazine-benzoic acid
  • HY-W007700
    8-Bromooctanoic acid 17696-11-6 99.89%
    8-Bromooctanoic acid is a PROTAC linker, and can be used for synthesis of PROTAC CYP1B1 degrader-2 (HY-158429).
    8-Bromooctanoic acid
  • HY-W004447
    Pentaethylene glycol di(p-toluenesulfonate) 41024-91-3 98.34%
    Pentaethylene glycol di(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Pentaethylene glycol di(p-toluenesulfonate)