2. Signaling Pathways
  3. Anti-infection
  4. Parasite
  5. Trypanosoma Isoform

Trypanosoma

Trypanosoma cruzi is a protozoan parasite transmitted by hematophagic triatomine insects (kissing bugs, reduviid bugs). Triatomine insects are the exclusive insect vectors for T. cruzi. .During a blood meal, triatomine insects defecate near the bite site, and due to the intense itching caused by triatomine saliva, individuals unknowingly rub the feces containing the infectious T. cruzi trypomastigotes into the bite wound, eye or nearby mucosal surfaces. The flagellated trypomastigotes invade various cells immediately inside the wound and transform into amastigotes. Intracellular amastigotes divide rapidly by binary fission, filling the cell and transforming back to trypomastigotes, rupturing the host cell in the process. Trypomastigotes disseminate through the bloodstream and can infect almost any tissue, repeating the amastigote-to-trypomastigote cycle. Triatomine insects may become infected during ingestion of a blood meal containing circulating trypomastigotes, thus continuing the parasite life cycle.T. cruzi can also be transmitted through other routes, including vertically to the fetus, by blood transfusion and organ transplantation.

Trypanosoma Related Products (62):

Cat. No. Product Name Effect Purity
  • HY-151942
    Antitrypanosomal agent 10
    		Inhibitor
    Antitrypanosomal agent 10 is an antitrypanosomal agent that inhibits Trypanosoma cruzi with an IC50 of 0.28 μM.
  • HY-N10441
    3β-Hydroxy-hop-22(29)-ene
    		Inhibitor
    3β-Hydroxy-hop-22(29)-ene (compound 3) is a potent antiparasitic agent. 3β-Hydroxy-hop-22(29)-ene shows moderate activity against Trypanosoma cruzi and Leishmania mexicana.
  • HY-121405
    Malonomicin
    		Inhibitor
    Malonomicin (Antibiotic K16) is an antibiotic with anti-protozoa and anti-trypanosome activities. Malonomicin also shows anti-trypanosome activity in vivo.
  • HY-126417
    Methylenetanshinquinone
    		Inhibitor
    Methylenetanshinquinone is a natural compound with antiplasmodial, antitrypanosomal and antioxidative activities. Methylenetanshinquinone can be used for the research of parasite infection.
  • HY-N11550
    Salviandulin E
    		Inhibitor
    Salviandulin E is a diterpenoid compound that can be isolated from Salvia leucantha CAV.. Salviandulin E shows antitrypanosomal activity against T. b. brucei GUTat 3.1 parasites with an IC50 value of 0.72 µg/mL.
  • HY-151485
    Anti-infective agent 5
    		Inhibitor
    Anti-infective agent 5 (compound 74) is an orally active inhibitor of Trypanosoma cruzi with an IC50 value of 0.10 μM. Anti-infective agent 5 effectively reduces parasite burden in vivo. Anti-infective agent 5 can be used for the research of infection.
  • HY-N2656
    5,7,8-Trimethoxycoumarin
    		Inhibitor
    5,7,8-Trimethoxycoumarin is an anti-parasite agent with IC50s of 25.5 μM and 57.7 μM against Trypanosoma cruzi and L. amazonensis, respectively.
  • HY-124623
    DNDI-8219
    		Inhibitor
    DNDI-8219 (compound 58) is a potent selective and orally active trypanocidal agent, possessing inhibitory activity against Trypanosoma cruzi (T. cruzi) with an IC50 of 0.4 μM. DNDI-8219 has low cytotoxicity (L6 cells IC50 > 100 μM). DNDI-8219 can effectively cure chronic T. cruzi infection and markedly reduce parasite burdens in mouse model. DNDI-8219 has good solubility, metabolic stability and safety.
  • HY-W040073S
    Nifurtimox-d4
    		Inhibitor
    Nifurtimox-d4 is deuterium labeled Nifurtimox. Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).
  • HY-N2392S
    Kukoamine A-d8 dihydrochloride
    		Inhibitor
    Kukoamine A-d8 (dihydrochloride) is deuterium labeled Kukoamine A. Kukoamine A is a natural occurring spermine derivative, acts as a potent inhibitor of trypanothione reductase (Ki, 1.8 μM), with antihypertensive activity[1].
  • HY-149078
    Antiparasitic agent-14
    		Inhibitor
    Antiparasitic agent-14 is a potent antiparasitic agent. Antiparasitic agent-14 shows cytotoxicity and antiparasitic activity. Antiparasitic agent-14 inhibits the growth of trypomastigote and amastigote.
  • HY-151943
    Antitrypanosomal agent 11
    		Inhibitor
    Antitrypanosomal agent 11 is an antitrypanosomal agent that inhibits Trypanosoma cruzi with an IC50 of 0.23 μM.
  • HY-115971
    Anti-Trypanosoma cruzi agent-1
    		Inhibitor
    Anti-Trypanosoma cruzi agent-1 (Compd E5) posseses anti-T. gondii activity.
  • HY-145287
    S-MGB-234
    S-MGB-234 is a minor groove binder of Animal African Trypanosomiasis (AAT). S-MGB-234 displays excellent in vitro activities against the principal causative organisms of AAT; Trypanosoma congolense, and Trypanosoma vivax. S-MGB-234 does not show cross-resistance with the current diamidine agents and are not internalized via the transporters used by diamidines.
  • HY-125648
    Euphorbadienol
    		Inhibitor
    Euphorbadienol (alpha-Euphorbol), a triterpenic compound, isolated from the latex of Euphorbia resinifera. The derivatives of Euphorbadienol can be used as elicitors of disease resistance, and has antileishmanial and antitrypanosomal activity.
  • HY-148323
    Anti-Trypanosoma cruzi agent-4
    		Inhibitor
    Anti-Trypanosoma cruzi agent-4 (compound 5c) is an inhibitor of Trypanosoma cruzi. Anti-Trypanosoma cruzi agent-4 can be used for the research of infection.
  • HY-149079
    Antiparasitic agent-15
    		Inhibitor
    Antiparasitic agent-15, a pyridine-thiazolidinone, has anti-Trypanosoma cruzi and leishmanicidal activities. Antiparasitic agent-15 has IC50s of 0.9 μM and 0.64 μM against trypomastigote and amastigote forms of T. cruzi. Antiparasitic agent-15 has IC50s of 42.2 μM and 9.58 μM against trypomastigote and amastigote forms of L. amazonensis. Antiparasitic agent-15 induces parasite cell death through necrosis induction. Antiparasitic agent-15 induces morphological changes such as shortening, retraction and curvature of the parasite body and leakage of internal content with T. cruzi trypomastigotes.
  • HY-N8257
    Dehydrobruceine A
    		Inhibitor
    Dehydrobruceine A is a low potent antitrypanosomal agent, with an IC50 of 88.5 nM for Plasmodium falciparum.
  • HY-146041
    Antiparasitic agent-2
    		Inhibitor
    Antiparasitic agent-2 (compound 8a) has highly antiparasitic activity against Leishmania infantum (L. infantum) and Trypanosoma cruzi (T. cruzi) with IC50s of 7.28 μM and 2.30 μM, respectively. Antiparasitic agent-2 also has certain cytotoxicity against HepG2 (CC50 = 26.79 μM).
  • HY-147549
    Antitrypanosomal agent 6
    		Inhibitor
    Antitrypanosomal agent 6 (compound 18a) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 6 is > 2-fold more potent against Trypanosoma brucei (T. brucei) than Nifurtimox, with an IC50 value of 0.47 μM. Antitrypanosomal agent 6 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA.