Proteasome

Related Products

Proteasomes are very large protein complexes inside all eukaryotes and archaea, and in some bacteria. In eukaryotes, they are located in the nucleus and the cytoplasm. The main function of the proteasome is to degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that carry out such reactions are called proteases. Proteasomes are part of a major mechanism by which cells regulate the concentration of particular proteins and degrade misfolded proteins. The degradation process yields peptides of about seven to eight amino acids long, which can then be further degraded into amino acids and used in synthesizing new proteins. Proteins are tagged for degradation with a small protein called ubiquitin. The tagging reaction is catalyzed by enzymes called ubiquitin ligases. Once a protein is tagged with a single ubiquitin molecule, this is a signal to other ligases to attach additional ubiquitin molecules. The result is a polyubiquitin chain that is bound by the proteasome, allowing it to degrade the tagged protein.

Proteasome Related Products (171)
Antibodies (21)

By Effects:	Inhibitors (134) Degrader (1) Activators (8) Modulator (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-137186

Suc-Gly-Gly-Phe-pNA
Suc-Gly-Gly-Phe-pNA is the chymotrypsin substrate with an K_m value of 1.6 mM.

HY-13067R

Celastrol (Standard)	Inhibitor
Celastrol (Standard) is the analytical standard of Celastrol. This product is intended for research and analytical applications. Celastrol (Tripterine;Tripterin) is a proteasome inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC₅₀ of 2.5 μM.

HY-113639

A-933548	Inhibitor
A-933548 is a potent and selective inhibitor of calpain, with a K_i of 18 nM. A-933548 can be used for the research of Alzheimer's disease.

HY-100193

FK-448 Free base	Inhibitor
FK-448 Free base is an effective and specific inhibitor of chymotrypsin, with an IC₅₀ of 720 nM.

HY-156105

8304-vs	Inhibitor
8304-vs is a macrocyclic anti-Plasmodial agent that covalently and irreversibly targets the Plasmodium proteasome. 8304-vs effectively inhibits the growth of Plasmodium falciparum.

HY-135070

Ac-RLR-AMC
Ac-RLR-AMC (Ac-Arg-Leu-Arg-AMC) is a fluorogenic substrate for the 26S proteasome (Ex/Em: 380/440-460 nm). AMC is released upon cleavage, and its fluorescence can be used to quantify the trypsin-like activity of 26S proteasomes.

HY-108553

Dihydroeponemycin	Inhibitor
Dihydroeponemycin, an analogue of the antitumor and antiangiogenic natural product eponemycin, selectively targets the 20S proteasome. Dihydroeponemycin covalently modifies a subset of catalytic proteasomal subunits, binding preferentially to the IFN-gamma-inducible subunits LMP2 and LMP7. Dihydroeponemycin-mediated proteasome inhibition induces a spindle-like cellular morphological change and apoptosis.

HY-P10003A

iso-VQA-ACC TFA
iso-VQA-ACC TFA is a constitutive proteasome substrate.

HY-169135

PROTAC 20S proteasome subunit β5 degrader 2	Degrader
PROTAC 20S proteasome subunit β5 degrader 2 is a PROTAC degrader for 20S proteasome subunit β5, with a DC₅₀ of 0.16 μM. PROTAC 20S proteasome subunit β5 degrader 2 inhibits the proliferation of cancer cell FaDu with IC₅₀ of 0.23 μM. PROTAC 20S proteasome subunit β5 degrader 2 exhibits antitumor efficacy in mice models. (Pink: Ligand for target protein (HY-10227); Blue: Ligand for E3 ligase (HY-103596); Black: Linker (HY-Y1760))

HY-P10007

Z-Gly-Pro-Phe-Leu-CHO	Inhibitor
Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde that acts as a highly selective and potent proteasomal inhibitor (K_i = 1.5 µM for branched chain amino acid preferring, 2.3 µM for small neutral amino acid preferring, and 40.5 µM for chymotrypsin-like activities; IC₅₀ = 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity).

HY-120035

DD1	Inhibitor	99.40%
DD1, a proteasome inhibitor, targets Bax activation and P70S6K degradation during acute myeloid leukemia (AML) apoptosis. DD1 induces apoptosis in the caspase-dependent manner. DD1 induces mitochondrial membrane depolarization and Bad dephosphorylation.

HY-P3356

Cyclotheonellazole A	Inhibitor
Cyclotheonellazole A is a natural macrocyclic peptide and a potent elastase inhibitor (IC₅₀=0.034 nM). Cyclotheonellazole A inhibits chymotrypsin with an IC₅₀ value of 0.62 nM.

HY-145542S

Isovalerylcarnitine-d₉ chloride
Isovalerylcarnitine-d₉ (chloride) is the deuterium labeled Isovalerylcarnitine (chloride)[1]. Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca2+-dependent proteinase (calpain) of human neutrophils[2].

HY-P10003

iso-VQA-ACC
iso-VQA-ACC is a substrate for constitutive proteasome.

HY-P4291

Z-Leu-Leu-Tyr-COCHO	Inhibitor
Z-Leu-Leu-Tyr-COCHO is a potent chymotrypsin-like activity inhibitor with a K_i value of 3.0 nM.

HY-125939

Bortezomib-pinanediol	Inhibitor
Bortezomib-pinanediol is a proteasome inhibitor and a prodrug of Bortezomib (HY-10227). Bortezomib-pinanediol inhibits cell growth and can be used for study of multiple myeloma.

HY-P4348

MeOSuc-Gly-Leu-Phe-AMC
MeOSuc-Gly-Leu-Phe-AMC is a peptide substrate of proteasomal.

HY-117513

CEP1612	Inhibitor
CEP1612 is a dipeptidyl proteasome inhibitor with the IC₅₀ of 60 nM. CEP1612 induces p21(WAF1)and p27(KIP1) expression and cell apoptosis. CEP1612 shows anticancer activity in vivo.

HY-P1259

PR-39	Inhibitor
PR-39, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 reversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the ubiquitin-proteasome pathway. PR-39 stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice.

HY-N2117R

Isoginkgetin (Standard)	Inhibitor
Isoginkgetin (Standard) is the analytical standard of Isoginkgetin. This product is intended for research and analytical applications. Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy.

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Proteasome

Proteasome

Proteasome Related Products (171)

Antibodies (21)

Proteasome Related Products (171):