2. Metabolic Enzyme/Protease Apoptosis
  3. Proteasome Apoptosis
  4. BT317

BT317 is a blood-brain transmissible mitochondrial Lon peptidase I (LonP1) and CT-L proteasome inhibitor. BT317 can increase the production of reactive oxygen species (ROS) and induce apoptosis in astrocytoma cells. BT317 has antitumor activity.

For research use only. We do not sell to patients.

BT317 Chemical Structure

BT317 Chemical Structure

CAS No. : 38485-94-8

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Based on 1 publication(s) in Google Scholar

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Description

BT317 is a blood-brain transmissible mitochondrial Lon peptidase I (LonP1) and CT-L proteasome inhibitor. BT317 can increase the production of reactive oxygen species (ROS) and induce apoptosis in astrocytoma cells. BT317 has antitumor activity[1].

Molecular Weight

329.73

Formula

C17H12ClNO4
CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

COC1=CC=C(C=C1)NC(C2=CC3=CC(Cl)=CC=C3OC2=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : 2 mg/mL (6.07 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0328 mL 15.1639 mL 30.3278 mL
5 mM 0.6066 mL 3.0328 mL 6.0656 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 3.0328 mL 15.1639 mL 30.3278 mL 75.8196 mL
5 mM 0.6066 mL 3.0328 mL 6.0656 mL 15.1639 mL
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BT317 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BT31738485-94-8BT 317BT-317ProteasomeApoptosisBT31LonP1CT-L proteasomeInhibitorantitumorinhibitorinhibit

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