2. Signaling Pathways
  3. GPCR/G Protein
    MAPK/ERK Pathway
  4. Ras

Ras

Ras

Related Products

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Ras is the name given to a family of related proteins which is ubiquitously expressed in all cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells. Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours. When Ras is 'switched on' by incoming signals, it subsequently switches on other proteins, which ultimately turn on genes involved in cell growth, differentiation and survival. As a result, mutations in ras genes can lead to the production of permanently activated Ras proteins. This can cause unintended and overactive signalling inside the cell, even in the absence of incoming signals. Because these signals result in cell growth and division, overactive Ras signaling can ultimately lead to cancer. The 3 Ras genes in humans (HRAS,KRAS, and NRAS) are the most common oncogenes in human cancer; Ras inhibitors are being studied as a treatment for cancer, and other diseases with Ras overexpression.

Ras Isoform Specific Products:

Ras Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-134243
    6-T-GDP
    		Inhibitor
    6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of azathioprine. 6-T-GDP can reduce the transcription of inflammatory factors and the expression of cell adhesion molecules by inhibiting the activity of Rac1, thereby inhibiting the migration of leukocytes and the occurrence of tissue inflammation.
    6-T-GDP
  • HY-132129
    SOS1-IN-2
    		Inhibitor
    SOS1-IN-2 (Compound 1-1) is an inhibitor of SOS1 with an IC50 value of 5 nM. SOS1-IN-2 can be used in tumor research.
    SOS1-IN-2
  • HY-12646A
    Rhosin
    		Inhibitor
    Rhosin is a potent, specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction with a Kd of ~ 0.4 uM, and does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin induces cell apoptosis. Rhosin promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability.
    Rhosin
  • HY-114277S2
    Sotorasib-d3
    		Inhibitor
    Sotorasib-d3 (AMG-510-d3) is deuterium labeled Sotorasib. Sotorasib (AMG-510) is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. Sotorasib irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state. Sotorasib leads to the regression of KRAS G12C?mutated locally advanced or metastatic non?small cell lung cancer (NSCLC).
    Sotorasib-d<sub>3</sub>
  • HY-131766
    2'-O-Me-cAMP
    		Activator
    2'-O-Me-cAMP is an analogue of natural signal molecule cAMP and a selective stimulator of the exchange factors activated by cAMP (Epac) with low membrane permeability.
    2'-O-Me-cAMP
  • HY-13868
    SCH-53870
    		Inhibitor
    SCH-53870 is a Ras activation inhibitor that binds to the Ras-GDP complex, keeping the Ras protein in an inactive GDP-bound state and preventing it from switching to an active GTP-bound state. SCH-53870 affects cell signaling and cell proliferation by preventing the activation of Ras protein. SCH-53870 can be used in cancer research.
    SCH-53870
  • HY-167828
    ARN25062
    		Inhibitor
    ARN25062 (compound 27) is a CDC42/RHOJ inhibitor with antitumor activity. ARN25062 is a novel trisubstituted pyrimidine derivative.
    ARN25062
  • HY-16111A
    BMS-214662 hydrochloride
    		Inhibitor
    BMS-214662 hydrochloride is an inhibitor of farnesyltransferase (Farnesyl Transferase). BMS-214662 hydrochloride can effectively block the localization and function of Ras proteins on the cell membrane by inhibiting the prenylation modification of Ras proteins, thereby exerting anti-tumor activity. The IC50 value of BMS-214662 hydrochloride for H-Ras is 1.3 nM, and for K-Ras it is 8.4 nM. BMS-214662 hydrochloride can be used in the research of tumor diseases related to Ras.
    BMS-214662 hydrochloride
  • HY-129283
    Goralatide
    		Activator
    Goralatide is a compound that regulates the thermal sensitivity of hematopoietic progenitor cells. It can reduce the thermal sensitivity of normal hematopoietic progenitor cells and increase the difference in thermal sensitivity between leukemia progenitor cells and normal progenitor cells, thereby increasing the inhibition window of hyperthermia therapy.
    Goralatide
  • HY-110038
    FTI-277 TFA
    		Inhibitor
    FTI-277 TFA is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 TFA can inhibit hepatitis delta virus (HDV) infection.
    FTI-277 TFA
  • HY-113680
    KY1022
    		Degrader
    KY1022 is a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway. KY1022 can inhibit cellular EMT, metastasis and apoptosis. KY1022 can be used for the research of metastatic colorectal cancer.
    KY1022
  • HY-W335254
    Deltarasin trihydrochloride
    		Inhibitor
    Deltarasin is an inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ. Deltarasin can be used in the study of cancer.
    Deltarasin trihydrochloride
  • HY-P991156
    Rapaprutug
    		Ligand
    Rapaprutug is a monoclonal antibody targeting human KARS1 (lysyl-tRNA synthetase 1). Rapaprutug blocks the relevant inflammatory signaling pathways in which KARS1 is involved, reducing the production and release of inflammatory factors. Rapaprutug is promising for research of inflammatory diseases.
    Rapaprutug
  • HY-166670S
    Ketoconazole carbonyl-13C
    		Inhibitor
    Ketoconazole carbonyl-13C (Ketoconazol-13C) is 13C labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
    Ketoconazole carbonyl-<sup>13</sup>C
  • HY-137630
    Sp-8-pCPT-2'-O-Me-cAMPS
    		Activator
    Sp-8-pCPT-2'-O-Me-cAMPS is an activator of EPAC. Sp-8-pCPT-2'-O-Me-cAMPS can be used in endocrine metabolism related research.
    Sp-8-pCPT-2'-O-Me-cAMPS
  • HY-12408
    6H05
    		Inhibitor
    6H05 is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C).
    6H05
  • HY-164513
    NHTD
    		Inhibitor
    NHTD is a KRAS-PDEδ inhibitor. NHTD targets the prenyl-binding pocket of PDEδ, altering the cellular localization of KRAS, thereby inhibiting the proliferation of KRAS-mutant cancer cells and inducing apoptosis. NHTD can be used for research on KRAS-driven non-small cell lung cancer (NSCLC).
    NHTD
Cat. No. Product Name / Synonyms Application Reactivity
Ras Isoform Comparison

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