Ras

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Ras is the name given to a family of related proteins which is ubiquitously expressed in all cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells. Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours. When Ras is 'switched on' by incoming signals, it subsequently switches on other proteins, which ultimately turn on genes involved in cell growth, differentiation and survival. As a result, mutations in ras genes can lead to the production of permanently activated Ras proteins. This can cause unintended and overactive signalling inside the cell, even in the absence of incoming signals. Because these signals result in cell growth and division, overactive Ras signaling can ultimately lead to cancer. The 3 Ras genes in humans (HRAS,KRAS, and NRAS) are the most common oncogenes in human cancer; Ras inhibitors are being studied as a treatment for cancer, and other diseases with Ras overexpression.

Ras Isoform Specific Products:

Ras Isoform Comparison

Ras Related Products (423)
Antibodies (34)
Ras Isoform Comparison

By Effects:	Inhibitors (370) Agonists (6) Degraders (13) Antagonists (2) Activators (16) Modulators (4)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-146223

AZD4625	Inhibitor	99.52%
AZD4625 (Compound 21) is a highly potent, selective, covalent and allosteric inhibitor of the mutant GTPase KRAS^G12C. AZD4625 has high oral bioavailability.

HY-148278

BI-0474	Inhibitor	99.83%
BI-0474 is a potent KRAS^G12C inhibitor with an IC₅₀ value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. BI-0474 exhibits good anti-proliferative activity against NCI-H358 cells carrying the G12C mutation. BI-0474 also shows good anti-tumour activity in non-small cell lung cancer xenograft models.

HY-15716

Kobe0065	Inhibitor	98.01%
Kobe0065 is a novel and effective inhibitor of Ras-Raf interaction, competitively inhibiting the binding of H-Ras·GTP to c-Raf-1 RBD with a K_i value of 46±13 μM.

HY-117149

MLS000532223	Inhibitor	99.46%
MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases, with EC₅₀ values ranging from 16 μM to 120 μM. MLS000532223 prevents GTP binding to several GTPases.

HY-111671

SOS1 activator 1	Activator	98.01%
SOS1 activator 1 (Compound 64) is a potent activator of SOS1-mediated nucleotide exchange with a K_d of 44 nM. SOS1 is a guanine nucleotide exchange factor that catalyzes the exchange of GDP for GTP on RAS.

HY-U00416

ARS-1323	Inhibitor	99.67%
ARS-1323, the racemate of ARS-1620, is a novel inhibitor of mutant K-ras G12C extracted from patent WO 2015054572 A1.

HY-162431

MK-1084	Inhibitor	99.82%
MK-1084 is a selective KRAS G12C inhibitor that is currently in Phase I clinical trial (NCT05067283). MK-1084 exhibits anticancer activity and can be used either alone or in combination with pembrolizumab (HY-P9902) for cancer research.

HY-125872

KRAS G12C inhibitor 14	Inhibitor	98.07%
KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 17, has an IC₅₀ of 18 nM.

HY-12408A

6H05 TFA	Inhibitor	99.02%
6H05 TFA is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C).

HY-158304

Rac1-IN-4	Inhibitor	98.61%
Rac1-IN-4 (Cas: 2924486-45-1) is a Rac1 inhibitor.

HY-145737A

PROTAC SOS1 degrader-1 TFA	Agonist	99.38%
PROTAC SOS1 degrader-1 (TFA) is a potent PROTAC SOS1 degrader with an DC₅₀ of 98.4 nM. PROTAC SOS1 degrader-1 shows antiproliferation activity in cancer cells with various KRAS mutations. PROTAC SOS1 degrader-1 shows antitumor effect with low toxicity.

HY-P1382A

Rac1 Inhibitor W56 TFA	Inhibitor	99.98%
Rac1 Inhibitor W56 TFA is a peptide containing residues 45-60 of Rac1. Rac1 Inhibitor W56 TFA inhibits Rac1 interaction with guanine nucleotide exchange factors TrioN, GEF-H1, and Tiam.

HY-16662

Oncrasin-1	Inhibitor	98.28%
Oncrasin-1 is a potent and effective anticancer inhibitor that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations; also led to abnormal aggregation of PKCι in nucleus of sensitive cells but not in resistant cells.

HY-138295

KRAS inhibitor-10	Inhibitor	99.92%
KRAS inhibitor-10 (compound 11) selectively and effectively inhibit RAS proteins, and particularly KRAS proteins. KRAS inhibitor-10 is an orally active anti-cancer agent and can be used for cancer research, such as pancreatic cancer, breast cancer, multiple myeloma, leukemia and lung cancer. KRAS inhibitor-10 is a tetrahydroisoquinoline compound (compound 11) extracted from patent WO2021005165 A1.

HY-153078

MRTF/SRF-IN-1	Inhibitor	99.68%
MRTF/SRF-IN-1 (example 41) is an inhibitor of both myocardin-related transcription factor and serum response factor (MRTF/SRF). MRTF/SRF-IN-1 can be used for research for preventing cancer and fibrosis.

HY-15717

Kobe2602	Inhibitor	99.55%
Kobe2602 is a Ras-Raf interaction inhibitor. Kobe2602 inhibits the binding of H-Ras·GTP to c-Raf-1 RBD with a K_i of 149 μM. Kobe2602 has antitumor activity.

HY-154959

AZD4747	Inhibitor	99.81%
AZD4747 is a selective, blood-brain barrier-permeable mutant GTPase KRAS^G12C inhibitor. AZD4747 has the potential to study cancer.

HY-108539A

(R)-CE3F4	Inhibitor	≥99.0%
(R)-CE3F4 is a potent and selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1), with an IC₅₀ of 4.2 μM, with 10-fold selectivity for Epac1 over Epac2 (IC₅₀, 44 μM). (R)-CE3F4 is more potent than racemic CE3F4 and (S)-CE3F4.

HY-125873

KRAS G12C inhibitor 15	Inhibitor	98.47%
KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 22, has an IC₅₀ of 5 nM.

HY-138294

RAS/RAS-RAF-IN-1	Inhibitor	99.81%
RAS/RAS-RAF-IN-1 is a potent RAS and RAS-RAF inhibitor. RAS/RAS-RAF-IN-1 has a K_D of 5.0 μΜ-15 μΜ for cyclophilin A (CYPA) binding affinity. RAS/RAS-RAF-IN-1 has antitumor activity.

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Ras

Ras

Ras Isoform Specific Products:

Ras Isoform Specific Products:

Ras Related Products (423)

Antibodies (34)

Ras Isoform Comparison

Ras Related Products (423):