2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. XMU-MP-9

XMU-MP-9 is a bifunctional compound that binds to the C2 domain of Nedd4-1 and the allosteric site of K-Ras. XMU-MP-9 enhances the interaction between Nedd4-1 and K-Ras, induces conformational changes in the Nedd4-1/K-Ras complex, promotes the ubiquitination and degradation of multiple K-Ras mutants, and inhibits the proliferation of cells carrying K-Ras mutants. XMU-MP-9 can be used in cancer research.

For research use only. We do not sell to patients.

XMU-MP-9 Chemical Structure

XMU-MP-9 Chemical Structure

CAS No. : 2251130-41-1

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5 mg USD 63 In-stock
10 mg USD 100 In-stock
25 mg USD 200 In-stock
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Based on 1 publication(s) in Google Scholar

XMU-MP-9 Related Antibodies

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K-Ras H-Ras N-Ras Ras

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Description

XMU-MP-9 is a bifunctional compound that binds to the C2 domain of Nedd4-1 and the allosteric site of K-Ras. XMU-MP-9 enhances the interaction between Nedd4-1 and K-Ras, induces conformational changes in the Nedd4-1/K-Ras complex, promotes the ubiquitination and degradation of multiple K-Ras mutants, and inhibits the proliferation of cells carrying K-Ras mutants. XMU-MP-9 can be used in cancer research[1].

Molecular Weight

385.84

Formula

C19H13ClFN3OS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC1=C(CNC(C2=CSC(C3=NNC4=CC=CC=C34)=C2)=O)C(Cl)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (323.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5917 mL 12.9587 mL 25.9175 mL
5 mM 0.5183 mL 2.5917 mL 5.1835 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5917 mL 12.9587 mL 25.9175 mL 64.7937 mL
5 mM 0.5183 mL 2.5917 mL 5.1835 mL 12.9587 mL
10 mM 0.2592 mL 1.2959 mL 2.5917 mL 6.4794 mL
15 mM 0.1728 mL 0.8639 mL 1.7278 mL 4.3196 mL
20 mM 0.1296 mL 0.6479 mL 1.2959 mL 3.2397 mL
25 mM 0.1037 mL 0.5183 mL 1.0367 mL 2.5917 mL
30 mM 0.0864 mL 0.4320 mL 0.8639 mL 2.1598 mL
40 mM 0.0648 mL 0.3240 mL 0.6479 mL 1.6198 mL
50 mM 0.0518 mL 0.2592 mL 0.5183 mL 1.2959 mL
60 mM 0.0432 mL 0.2160 mL 0.4320 mL 1.0799 mL
80 mM 0.0324 mL 0.1620 mL 0.3240 mL 0.8099 mL
100 mM 0.0259 mL 0.1296 mL 0.2592 mL 0.6479 mL
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XMU-MP-9 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XMU-MP-92251130-41-1RasE3 ubiquitin ligaseK-RASdegradationcancerproliferationubiquitinationInhibitorinhibitorinhibit

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