(R)-BI-2852

Cat. No.: HY-126247B Purity: 97.32% ee.: 100.00%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

(R)-BI-2852 is the isomer of BI-2852 (HY-126247), and can be used as an experimental control. BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based agent design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) and binds ten-fold more strongly to active KRASG12D versus KRASwt (740 nM vs 7.5 μM). BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.

For research use only. We do not sell to patients.

(R)-BI-2852 Chemical Structure

CAS No. : 2375482-49-6

Size	Price	Stock	Quantity
5 mg	USD 230	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 360	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1100	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1750	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of (R)-BI-2852:

BI-2852 Get quote

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Description

Molecular Weight

516.59

Formula

C₃₁H₂₈N₆O₂

CAS No.

2375482-49-6

Appearance

Solid

Color

Off-white to light yellow

SMILES

OC(C=C1)=CC([C@H](C2=C(CNCC3=CC4=C(C=CN4CC5=CN(C)C=N5)C=C3)NC6=CC=CC=C62)N7)=C1C7=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 55 mg/mL (106.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9358 mL	9.6789 mL	19.3577 mL
5 mM	0.3872 mL	1.9358 mL	3.8715 mL
10 mM	0.1936 mL	0.9679 mL	1.9358 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 97.32% ee.: 100.00%

Select Batch:

Data Sheet (280 KB) SDS (252 KB)

COA (263 KB) HNMR (314 KB) NP-HPLC (271 KB) LCMS (142 KB)

Handling Instructions (2659 KB)

References

[1]. Dirk Kessler, et al. Drugging all RAS isoforms with one pocket. FUTURE MEDICINAL CHEMISTRY

[2]. Kessler D, et al. Drugging an undruggable pocket on KRAS. Proc Natl Acad Sci U S A. 2019 Aug 6; 116(32):15823-15829. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9358 mL	9.6789 mL	19.3577 mL	48.3943 mL
	5 mM	0.3872 mL	1.9358 mL	3.8715 mL	9.6789 mL
	10 mM	0.1936 mL	0.9679 mL	1.9358 mL	4.8394 mL
	15 mM	0.1291 mL	0.6453 mL	1.2905 mL	3.2263 mL
	20 mM	0.0968 mL	0.4839 mL	0.9679 mL	2.4197 mL
	25 mM	0.0774 mL	0.3872 mL	0.7743 mL	1.9358 mL
	30 mM	0.0645 mL	0.3226 mL	0.6453 mL	1.6131 mL
	40 mM	0.0484 mL	0.2420 mL	0.4839 mL	1.2099 mL
	50 mM	0.0387 mL	0.1936 mL	0.3872 mL	0.9679 mL
	60 mM	0.0323 mL	0.1613 mL	0.3226 mL	0.8066 mL
	80 mM	0.0242 mL	0.1210 mL	0.2420 mL	0.6049 mL
	100 mM	0.0194 mL	0.0968 mL	0.1936 mL	0.4839 mL

(R)-BI-2852 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-BI-28522375482-49-6OthersInhibitorinhibitorinhibit

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(R)-BI-2852

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Complete Stock Solution Preparation Table

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