2. GPCR/G Protein MAPK/ERK Pathway
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  4. KRAS G12C inhibitor 14

KRAS G12C inhibitor 14 

Cat. No.: HY-125872 Purity: 98.07% ee.: 99.24%
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KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 17, has an IC50 of 18 nM.

For research use only. We do not sell to patients.

KRAS G12C inhibitor 14 Chemical Structure

KRAS G12C inhibitor 14 Chemical Structure

CAS No. : 2349393-95-7

Size Price Stock Quantity
1 mg USD 280 In-stock
5 mg USD 710 In-stock
10 mg USD 1150 In-stock
25 mg USD 2300 In-stock
50 mg USD 3800 In-stock
100 mg USD 5900 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 17, has an IC50 of 18 nM[1].

IC50 & Target[1]

KRas G12C

18 nM (IC50)

Molecular Weight

484.88

Formula

C24H19ClF2N4O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

FC1=CC=CC(O)=[C@@]1[C@@]2=C(F)C(N=CC(N3C)=C4N5[C@H](CN(C(C=C)=O)CC5)C3=O)=C4C=C2Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (206.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0624 mL 10.3118 mL 20.6237 mL
5 mM 0.4125 mL 2.0624 mL 4.1247 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 9 mg/mL (18.56 mM); Clear solution

    This protocol yields a clear solution of ≥ 9 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (90.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0624 mL 10.3118 mL 20.6237 mL 51.5591 mL
5 mM 0.4125 mL 2.0624 mL 4.1247 mL 10.3118 mL
10 mM 0.2062 mL 1.0312 mL 2.0624 mL 5.1559 mL
15 mM 0.1375 mL 0.6875 mL 1.3749 mL 3.4373 mL
20 mM 0.1031 mL 0.5156 mL 1.0312 mL 2.5780 mL
25 mM 0.0825 mL 0.4125 mL 0.8249 mL 2.0624 mL
30 mM 0.0687 mL 0.3437 mL 0.6875 mL 1.7186 mL
40 mM 0.0516 mL 0.2578 mL 0.5156 mL 1.2890 mL
50 mM 0.0412 mL 0.2062 mL 0.4125 mL 1.0312 mL
60 mM 0.0344 mL 0.1719 mL 0.3437 mL 0.8593 mL
80 mM 0.0258 mL 0.1289 mL 0.2578 mL 0.6445 mL
100 mM 0.0206 mL 0.1031 mL 0.2062 mL 0.5156 mL
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KRAS G12C inhibitor 14 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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KRAS G12C inhibitor 142349393-95-7RasInhibitorinhibitorinhibit

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