2. Signaling Pathways
  3. Immunology/Inflammation
  4. STING

STING

Stimulator of Interferon Genes; TMEM173; MITA; ERIS; MPYS

STING

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Stimulator of interferon genes (STING) is an integral ER-membrane protein that can be activated by 2'3'-cGAMP synthesized by cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) upon binding of double-stranded DNA. It activates interferon (IFN) and inflammatory cytokine responses to defend against infection by microorganisms.

STING is a key cytosolic receptor for small nucleotides and plays a key role in anticancer and antiviral immunity. STING signaling pathway is also a critical link between innate and adaptive immunity, and induces anti-tumor immune responses. STING agonists, such as endogenous cyclic dinucleotide (CDN) cyclic GMP-AMP (cGAMP), have been used in diverse research for immunogenic tumor clearance, antiviral treatments and vaccine adjuvants.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-160406
    SNX281
    		Agonist 99.08%
    SNX281 is a systemically active STING agonist that binds to the STING protein, promotes signal transduction of the cGAS-STING pathway, and increases cellular responses to tumor cells. SNX281 can be used in the study of anti-tumor immunity.
    SNX281
  • HY-162874
    diABZI-V/C-DBCO
    		Agonist 98.00%
    diABZI-V/C-DBCO (Compound 3) is a potent STING agonist. diABZI-V/C-DBCO can release diABZI-amine upon activation by cathepsin B to activate STING, leading to the production of interferons and other immune-stimulatory molecules, thereby enhancing the immune system's response to tumors. The EC50 values for diABZI-V/C-DBCO and diABZI-amine in activating STING in THP1-Dual cells are 1.47 and 0.144 nM, respectively, and in primary mouse splenocytes, the EC50 values are 7.7 and 0.17 μM, respectively. diABZI-V/C-DBCO can be used in cancer immunotherapy research.
    diABZI-V/C-DBCO
  • HY-12326
    c-di-AMP
    		Agonist 99.29%
    c-di-AMP (Cyclic diadenylate) is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP (Cyclic diadenylate) is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP (Cyclic diadenylate) acts as a potent mucosal adjuvant stimulating both humoral and cellular responses.
    c-di-AMP
  • HY-139586
    Ulevostinag
    		Agonist 98.05%
    Ulevostinag (MK-1454) is a potent cyclic dinucleotide agonist stimulator of interferon genes (STING). Ulevostinag (MK-1454) acts in the intra-tumoral route by targeting the stimulator of interferon genes (STING) protein. Ulevostinag (MK-1454) can be used for immuno-tumor cancer disease research.
    Ulevostinag
  • HY-143896
    STING agonist-7
    		Agonist
    STING agonist-7 is a non-nucleotide STING agonist. STING agonist-7 binds selectively to mouse STING but not human STING. STING agonist-7 penetrates cell membrane poorly.
    STING agonist-7
  • HY-148346A
    STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA
    		Agonist 98.30%
    STING agonist-20-Ala-amide-PEG2-C2-NH2 (Compound 30b) TFA is an active scaffold comprising a stimulator of interferon genes (STING). STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA can be used to synthesize immune-stimulating antibody conjugate (ISAC). STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA can be used for the research of cancer.
    STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA
  • HY-131454A
    SR-717 free acid
    		Agonist 98.05%
    SR-717 free acid is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 free acid is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity.
    SR-717 free acid
  • HY-130115B
    IACS-8803 diammonium
    		Agonist 98.79%
    IACS-8803 diammonium is a highly potent cyclic dinucleotide STING agonist. IACS-8803 diammonium has a robust systemic antitumor efficacy.
    IACS-8803 diammonium
  • HY-152959
    STING agonist-26
    		Agonist 99.56%
    STING agonist-26 (CF508) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains.
    STING agonist-26
  • HY-143320
    STING agonist-17
    		Agonist
    STING agonist-17 (compound 4a) is a potent STING agonist with an IC50 value of 0.062 nM. STING agonist-17 has anti-cancer activity for tumor immunization.
    STING agonist-17
  • HY-137724A
    C-di-IMP disodium
    		Agonist 99.9%
    C-di-IMP disodium is a STING agonist. C-di-IMP disodium can be used in tumor research.
    C-di-IMP disodium
  • HY-163668
    MK-2118
    		Agonist
    MK-2118 is a GMP-synthesized STING agonist with the potential to inhibit advanced/metastatic solid tumors or lymphomas..
    MK-2118
  • HY-164278
    diABZI-V/C-Mal
    		Agonist 99.28%
    diABZI-V/C-Mal is a STING agonist.
    diABZI-V/C-Mal
  • HY-130115
    IACS-8803
    		Agonist
    IACS-8803 is a highly potent cyclic dinucleotide STING agonist with robust systemic antitumor efficacy.
    IACS-8803
  • HY-144168A
    STING agonist-8 dihydrochloride
    		Agonist
    STING agonist-8 dihydrochloride (compound 5-AB) is a potent STING agonist with an EC50 of 27 nM in THP1-Dual KI-hSTING-R232 cells.
    STING agonist-8 dihydrochloride
  • HY-122568
    STING agonist-15
    		Agonist ≥99.0%
    STING agonist-15 (Compound STING agonist-C11) Is a STING agonist. STING agonist-15 can be used for research of cancer and immune response.
    STING agonist-15
  • HY-144168
    STING agonist-8
    		Agonist
    STING agonist-8 is a potent STING agonist with an EC50 of 27 nM in THP1-Dual KI-hSTING-R232 cells (WO2021239068A1, compound 5-AB).
    STING agonist-8
  • HY-162465
    BDW568
    		Agonist 99.4%
    BDW568 is a STING agonist that can selectively activate the human STINGA230 allele. BDW568 can be used to activate STINGA230-engineered macrophages in macrophage-based immunotherapy.
    BDW568
  • HY-148346
    STING agonist-20-Ala-amide-PEG2-C2-NH2
    		Agonist
    STING agonist-20-Ala-amide-PEG2-C2-NH2 is an active scaffold comprising a stimulator of interferon genes (STING). STING agonist-20-Ala-amide-PEG2-C2-NH2 can be used to synthesize immune-stimulating antibody conjugate (ISAC). STING agonist-20-Ala-amide-PEG2-C2-NH2 can be used for the research of cancer.
    STING agonist-20-Ala-amide-PEG2-C2-NH2
  • HY-112921
    diABZI STING agonist-1 (tautomerism)
    		Agonist
    diABZI STING agonist-1 tautomerism is a tautomerism of diABZI STING agonist-1 (HY-112921) (compound 3). diABZI STING agonist-1 tautomerism is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
    diABZI STING agonist-1 (tautomerism)
Cat. No. Product Name / Synonyms Application Reactivity