2. Signaling Pathways
  3. Stem Cell/Wnt
  4. Smo

Smo

Smoothened

Smo

Related Products

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Smoothened (Smo), a class Frizzled G protein-coupled receptor (class F GPCR), transduces the Hedgehog (Hh) signal across the cell membrane. The Hh signaling pathway includes both canonical and noncanonical pathways. The canonical Hh pathway functions through major Hh molecules such as Hh ligands, PTCH, Smo, and GLI, whereas the noncanonical Hh pathway involves the activation of Smo or GLI through other pathways.

The Hh signaling cascade is initiated by the binding of the Hh protein ligand to its cellular membrane receptor, Patched (PTCH), which relieves PTCH-mediated repression of the seven-transmembrane (7TM) protein Smo. Activated Smo transduces the signal to the GLI family of transcription factors, which translocate to the nucleus to regulate numerous gene products involved in tissue patterning and cell differentiation.

Smo Related Products (63):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-12848
    SAG
    		Agonist 99.79%
    SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo.
    SAG
  • HY-17024
    Cyclopamine
    		Inhibitor 99.97%
    Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC50 of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor.
    Cyclopamine
  • HY-15108
    Purmorphamine
    		Activator 99.9%
    Purmorphamine is a smoothened/Smo receptor agonist with an EC50 of 1 μM.
    Purmorphamine
  • HY-16582A
    Sonidegib
    		Antagonist 99.94%
    Sonidegib (Erismodegib) is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively.
    Sonidegib
  • HY-12848B
    SAG hydrochloride
    		Agonist 99.63%
    SAG hydrochloride is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG hydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo.
    SAG hydrochloride
  • HY-N0836R
    Jervine (Standard)
    		Inhibitor
    Jervine (Standard) is the analytical standard of Jervine. This product is intended for research and analytical applications. Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC50 of 500-700 nM. Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum nigrum. Jervine has anti-inflammatory and antioxidant properties.
    Jervine (Standard)
  • HY-159893
    SMO-IN-5
    		Inhibitor
    SMO-IN-5 ((Compound 25(B31)) is a potent smoothened (SMO) inhibitor that inhibits Hedgehog (Hh) signaling. SMO-IN-5 can inhibit cell proliferation and induce Apoptosis. SMO-IN-5 has antitumor activity.
    SMO-IN-5
  • HY-17024R
    Cyclopamine (Standard)
    		Inhibitor
    Cyclopamine (Standard) is the analytical standard of Cyclopamine. This product is intended for research and analytical applications. Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC50 of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor.
    Cyclopamine (Standard)
  • HY-100224
    SANT-1
    		Antagonist 99.87%
    SANT-1, a potent Smo antagonist, inhibits Hedgehog signaling. SANT-1 shows IC50s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 assay, respectively.
    SANT-1
  • HY-16391
    Glasdegib
    		Inhibitor 99.31%
    Glasdegib (PF-04449913) is a potent and orally bioavailable smoothened inhibitor. Glasdegib (PF-04449913) binds to human SMO (amino acids 181-787) with an IC50 of 4 nM.
    Glasdegib
  • HY-12848C
    SAG dihydrochloride
    		Agonist 99.56%
    SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo.
    SAG dihydrochloride
  • HY-15483
    DY131
    		Inhibitor 99.72%
    DY131 (GSK 9089) is a potent and selective ERRγ and ERRβ agonist. DY131displays inactive against ERRα, ERα and ERβ. DY131 also inhibits Smo signaling.
    DY131
  • HY-12316
    20(S)-Hydroxycholesterol
    		Activator 98.70%
    20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC50 of 3 μM in a gene transcription reporter assay using NIH3T3 cells.
    20(S)-Hydroxycholesterol
  • HY-13242
    Taladegib
    		Inhibitor 99.57%
    Taladegib (LY2940680) is an antagonist of the smoothened receptor.
    Taladegib
  • HY-100535
    KAAD-Cyclopamine
    		Antagonist
    KAAD-Cyclopamine, a hedgehog signaling inhibitor, is a smoothened antagonist.
    KAAD-Cyclopamine
  • HY-13809
    BMS-833923
    		Inhibitor 98.11%
    BMS-833923 (XL-139) is an orally biocompatible Smoothened (Smo) inhibitor with anti-tumor activity. It can inhibit the binding of BODIPY cyclopamine to SMO in a dose-dependent manner with an IC50 of 21 nM.
    BMS-833923
  • HY-16582
    Sonidegib diphosphate
    		Antagonist 99.73%
    Sonidegib diphosphate (Erismodegib diphosphate) is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively.
    Sonidegib diphosphate
  • HY-12317
    GSA-10
    		Agonist 98.01%
    GSA-10 is a potent smooth (Smo) receptor agonist. GSA-10 is a potent osteogenic molecule. GSA-10 can mediate Hedgehog (Hh) signaling. GSA-10 can be used in regenerative medicine for cancer disease and in the study of fat development.
    GSA-10
  • HY-16587
    Saridegib
    		Inhibitor 99.87%
    Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.
    Saridegib
  • HY-B0877
    Halcinonide
    		Agonist 99.56%
    Halcinonide (SQ-18566) is a high potency corticosteroid used topically in the treatment of certain skin conditions.
    Halcinonide