Thrombin

Related Products

Thrombin is a Na⁺-activated, serine protease which is activated by the enzymatic cleavage of two sites on prothrombin by activated Factor X. Thrombin exists in two allosteric forms, slow (S) and fast (F), target toward anticoagulant and procoagulant activities.

Thrombin is the main effector protease in primary hemostasis by activating platelets and plays a key role in secondary hemostasis. Besides its well-known functions in hemostasis, thrombin also plays a role in various non-hemostatic biological and pathophysiologic processes, predominantly mediated through activation of protease-activated receptors (PARs). PAR-1, PAR-3, and PAR-4 are cleaved by thrombin, whereas PAR-2 is cleaved by trypsin. Thrombin also plays a crucial role in the migration and metastasis of human cancer cells.

Thrombin Related Products (147)
Antibodies (9)

By Effects:	Substrates (2) Ligand (1) Inhibitors (107) Agonists (2) Antagonists (4) Activators (4)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-105069A

Rusalatide acetate	Ligand	98.51%
Rusalatide acetate (TP508 amide acetate), a regenerative peptide, mitigates radiation-induced gastrointestinal damage by activating stem cells and preserving crypt integrity.

HY-P1921

YRGDS Fibronectin Fragment		98.86%
YRGDS Fibronectin Fragment is a fibronectin fragment, an adhesion peptide that displays strong binding affinity to thrombin-stimulated platelets.

HY-10163AS

Dabigatran-d₄ hydrochloride	Inhibitor	≥98.0%
Dabigatran-d₄ (hydrochloride) is deuterium labeled Dabigatran, which is a reversible and selective, direct thrombin inhibitor (DTI) with a K_i value of 4.5 nM.

HY-10217

Thrombin Inhibitor 2	Inhibitor	99.92%
Thrombin Inhibitor 2 is a small molecule direct thrombin inhibitor, extracted from US8541580B2. Thrombin Inhibitor 2 has antithrombotic activity.

HY-10264A

Edoxaban tosylate	Inhibitor	99.84%
Edoxaban (DU-176b) tosylate is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with K_is of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban tosylate exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban tosylate can be used for preventing thromboembolic disease research.

HY-10277

Odiparcil	Inhibitor	99.98%
Odiparcil (SB-424323) is an orally active beta-d-thioxyloside analog with antithrombotic activity associated with a reduced risk of adverse bleeding events. Odiparcil (SB-424323) is indirect thrombin inhibitor that exerts its anticoagulant effect through activation of antithrombin II (heparin cofactor II) .

HY-10163S

Dabigatran-d₄	Inhibitor
Dabigatran-d₄ is deuterium labeled Dabigatran. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[1][2].

HY-134686

Edoxaban impurity 4	Inhibitor	99.08%
Edoxaban impurity 4 is an impurity of Edoxaban. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with K_is of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and can be used for stroke prevention.

HY-W014134

p-APMSF hydrochloride	Inhibitor
p-APMSF is an irreversible inhibitor of serinase. p-APMSF has substrate specificity for positively charged side chains of amino acids, lysine, or arginine. p-APMSF can be used to study the irreversible inhibition of trypsin and thrombin .

HY-129496

NP-313	Inhibitor	99.58%
NP-313 is a potent antithrombotic agent that inhibits platelet aggregation and activation. NP-313 has dual inhibition of thromboxane A 2 synthesis and selective inhibition of SOCC-mediated Ca²⁺ inward flow.

HY-162109

Thrombin inhibitor 11	Inhibitor	99.77%
Thrombin inhibitor 11 is a thrombin inhibitor, with human and rat K_i values of 65 nM and 10.3 nM, respectively.

HY-17567

Heparin	Inhibitor
Heparin is a highly sulfated glycosaminoglycan,that is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule. Heparin significantly inhibits exosome-cell interactions.

HY-142163

S62798	Inhibitor
S62798 is a selective and potent inhibitor of activated thrombin activatable fibrinolysis inhibitor (TAFIa) with an IC₅₀ value of 6 mM.

HY-142661

BAY 1217224	Inhibitor
BAY 1217224 is a neutral, non-proagent Thrombin inhibitor with good oral pharmacokinetics.

HY-10264C

Edoxaban hydrochloride	Inhibitor
Edoxaban (DU-176b) hydrochloride is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with K_i values of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban hydrochloride exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban hydrochloride can be used for preventing thromboembolic disease research.

HY-11091

Razaxaban hydrochloride	Inhibitor
Razaxaban hydrochloride (BMS 561389 hydrochloride) is a highly potent, selective and orally active factor Xa inhibitor with a K_i of 0.19 nM. Razaxaban hydrochloride exhibits excellent selectivity (>5000-fold) for factor Xa over other related serine proteases. Razaxaban hydrochloride is also a potent thrombin inhibitor with a K_i of 540 nM. Razaxaban hydrochloride has strongly antithrombotic activity.

HY-P99465

Befovacimab	Inhibitor
Befovacimab (BAY 1093884) is a fully human monoclonal IgG2 antibody able to bind to tissue factor pathway inhibitor (TFPI). Befovacimab can be used for haemophilia A/B research.

HY-B0375S

Argatroban-d₃	Inhibitor
Argatroban-d₃ is the deuterium labeled Argatroban. Argatroban (MD-805) is a direct, selective thrombin inhibitor.

HY-P2490

Acetyl-Hirudin (54-65) sulfated
Acetyl-Hirudin (54-65) (sulfated) is a acetyl-fragment of Hirudin which binds directly to thrombin-rHCII(L444R) and disrupts interactions between the N-terminal acidic domain of rHCII and anion-binding exosite I of thrombin that serves to stabilize the complex.

HY-118220

EP 171	Agonist
EP 171 is a TP receptor agonist and human platelet activator. EP 171 can induce constriction of guinea pig trachea, and the constriction can be inhibited by the TP receptor antagonist EP 092. EP 171 binds to TP receptors on intact human platelets with an IC₅₀ of 2.9 nM.

Name
Email *

	Sorry, but the email address you supplied was invalid.

Thrombin

Thrombin

Thrombin Related Products (147)

Antibodies (9)

Thrombin Related Products (147):