2. Metabolic Enzyme/Protease
  3. Thrombin
  4. Befovacimab

Befovacimab  (Synonyms: BAY 1093884)

Cat. No.: HY-P99465
Data Sheet Technical Support

Befovacimab (BAY 1093884) is a fully human monoclonal IgG2 antibody able to bind to tissue factor pathway inhibitor (TFPI). Befovacimab can be used for haemophilia A/B research.

For research use only. We do not sell to patients.

CAS No. : 2156634-62-5

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Description

Befovacimab (BAY 1093884) is a fully human monoclonal IgG2 antibody able to bind to tissue factor pathway inhibitor (TFPI). Befovacimab can be used for haemophilia A/B research[1].

Isotype

IgG2-lambda
Species

Humanized

In Vitro

Befovacimab binds human TFPI with high affinity (<10 pM) via the K1 and K2 domains, inhibiting its interactions with both FXa and FVIIa and thus restoring their activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

In monkey plasma, Befovacimab exhibits an IC50 of 4.65 nM and 6.19 nM for free TFPI and diluted prothrombin time (dPT), respectively[1].
Befovacimab (5 and 20 mg/kg; intravenous and subcutaneous administration) dose‐dependent decreases in TFPI concentration and clotting time in female cynomolgus monkeys in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS No.
SMILES

[Befovacimab]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG2 lambda
Purity & Documentation
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Keywords:

Befovacimab2156634-62-5BAY 1093884BAY1093884BAY-1093884Thrombinmonoclonal IgG2 antibodyhaemophilia A/BTFPIInhibitorinhibitorinhibit

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