Thrombin

Related Products

Thrombin is a Na⁺-activated, serine protease which is activated by the enzymatic cleavage of two sites on prothrombin by activated Factor X. Thrombin exists in two allosteric forms, slow (S) and fast (F), target toward anticoagulant and procoagulant activities.

Thrombin is the main effector protease in primary hemostasis by activating platelets and plays a key role in secondary hemostasis. Besides its well-known functions in hemostasis, thrombin also plays a role in various non-hemostatic biological and pathophysiologic processes, predominantly mediated through activation of protease-activated receptors (PARs). PAR-1, PAR-3, and PAR-4 are cleaved by thrombin, whereas PAR-2 is cleaved by trypsin. Thrombin also plays a crucial role in the migration and metastasis of human cancer cells.

Thrombin Related Products (151)
Antibodies (9)

By Effects:	Substrates (2) Ligand (1) Inhibitors (111) Agonists (2) Antagonists (4) Activators (4)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-P4721

Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)
Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is a hirugen-like peptide, and has high affnity for thrombin than Hirugen, with a K_D < 100 nM. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is an antithrombotic agent. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) inhibits the thrombin-induced fibrin clot formation with an IC50 value of 0.087 μM.

HY-P1493

Fibrinopeptide B, human
Fibrinopeptide B, human is a 14-aa peptide, released from the amino-terminus of β-chains of fibrinogen by thrombin.

HY-B0375R

Argatroban (Standard)	Inhibitor
Argatroban (Standard) is the analytical standard of Argatroban. This product is intended for research and analytical applications. Argatroban (MD-805) is a direct, selective thrombin inhibitor.

HY-123550

Rosenonolactone	Inhibitor
Rosenonolactone shows inhibitory activity against prolyl endopeptidase and thrombin and cholesterol ester transfer protein.

HY-P2920

Protamine from salmon
Protamine from salmon is a biochemical agent with antioxidant, antiheparin and antimicrobial activities. Protamine from salmon neutralizes the anticoagulant effect of heparin, thereby preventing the formation of antithrombin complexes in canine samples pretreated with heparin in vitro.

HY-P5889

Thrombin receptor peptide ligand	Antagonist
Thrombin receptor peptide ligand is a thrombin receptor antagonist peptide that can be used as an antithrombotic agent.

HY-10270

Flovagatran	Inhibitor
Flovagatran (TGN 255) is a potent and reversible thrombin inhibitor (K_i: 9 nM). Flovagatran can be used in the research of arterial and venous thrombosis.

HY-P1636

Hirudin (54-65)	Inhibitor
Hirudin (54-65) is a fragment of Hirudin with anticoagulant effects. Hirudin is a thrombin inhibitor with blood anticoagulant property.

HY-P4259

Hirullin P18	Inhibitor
Hirullin P18 is a potent thrombin inhibitor. Hirullin P18 has an anticoagulant effect.

HY-10273

Atecegatran metoxil	Inhibitor
Atecegatran metoxil is a oral anticoagulant, which inhibits thrombin factor II and is used in thromboembolic disorders. In vivo, Atecegatran metoxil is converted to AR-H067637, a selective and reversible direct thrombin inhibitor.

HY-114164B

Human γ-Thrombin
Human γ-Thrombin (Human Gamma Thrombin) is a variant of an enzyme that is further hydrolyzed from Thrombin. Human γ-Thrombin is produced by the hydrolysis of α-thrombin by factor X (fXa) or other plasma proteases such as hydrolases and plasmin, and can selectively activate platelets through specific receptors. Human γ-Thrombin can be used in the research of antithrombotic drugs.

HY-109549

Desirudin	Inhibitor
Desirudin (CGP 39393) is a thrombin inhibitor. Desirudin can inhibit the formation of blood clots and venous stasis thrombosis, which is used for the research of thrombocytopenia or platelet dysfunction.

HY-P1100

PM102	Antagonist
PM102 (HepArrest) is a heparin antagonist that can reverses the anticoagulant effect of heparin. PM102 potently binds heparin (Kd = 36 nM) in vitro.

HY-10274S

Dabigatran etexilate-d₁₃	Inhibitor	≥98.0%
Dabigatran etexilate-d₁₃ is the deuterium labeled Dabigatran etexilate. Dabigatran etexilate (BIBR 1048) is an orally active proagent of Dabigatran. Dabigatran etexilate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation[1].

HY-14936

Sofigatran	Inhibitor
Sofigatran (MCC-977) is an orally active factor IIa (thrombin) inhibitor, acts as an anticoagulant. Sofigatran is used for the research of cardiovascular disease.

HY-N10762

15,16-Dihydrotanshindiol C	Inhibitor
15,16-Dihydrotanshindiol C, a diterpenoid, is a potent thrombin inhibitor.

HY-P4475

Sar-Pro-Arg-pNA
Sar-Pro-Arg-pNA is a chromogenic substrate of α-thrombin. Sar-Pro-Arg-pNA can be used to test α-thrombin activity.

HY-114603

Efegatran	Inhibitor
Efegatran (LY 294468) is an inhibitor for thrombin, which inhibits aggregation of platelets, and exhibits anticoagulant and antithrombotic activities.

HY-10163R

Dabigatran (Standard)	Inhibitor
Dabigatran (Standard) is the analytical standard of Dabigatran. This product is intended for research and analytical applications. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM).

HY-E70393C

Human Factor XIa
Human Factor XIa is a blood coagulation protease. Human Factor XIa activates the Factor IX and Factor V, resulting in the generation of thrombin and fibrin.

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Thrombin

Thrombin

Thrombin Related Products (151)

Antibodies (9)

Thrombin Related Products (151):