2. Signaling Pathways
  3. Immunology/Inflammation
  4. AP-1
  5. c-Jun Isoform
  6. c-Jun Inhibitor

c-Jun Inhibitor

c-Jun Inhibitor (1):

Cat. No. Product Name Effect Purity
  • HY-168895
    c-Fos-IN-1
    		Inhibitor
    c-Fos-IN-1 (Compound P16) is a c-Jun inhibitor, and decreases mRNA levels and protein levels of c-Fos. c-Fos-IN-1 also inhibits the phosphorylation activity of ERK and the transcriptional activity of AP-1. c-Fos-IN-1 shows anticancer activity by inhibiting ERK/c-Fos/Jun pathway. c-Fos-IN-1 inhibits the proliferation and migration of gastric cancer cells (IC50: 2.31 μM for MGC-803 cell). c-Fos-IN-1 arrests cell cycle at G2/M phase and induces cancer cell apoptosis. c-Fos-IN-1 inhibits gastric cancer tumor growth.