2. PROTAC Autophagy
  3. AUTOTACs Autophagy
  4. PBA-1105

PBA-1105 is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. PBA-1105 selectively binds to exposed hydrophobic regions of misfolded proteins, facilitating their degradation via the autophagic pathway. PBA-1105 increases the autophagic flux of Ub-conjugated aggregates.

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PBA-1105 Chemical Structure

PBA-1105 Chemical Structure

CAS No. : 2410081-56-8

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Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

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PBA-1105 Related Antibodies

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Description

PBA-1105 is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. PBA-1105 selectively binds to exposed hydrophobic regions of misfolded proteins, facilitating their degradation via the autophagic pathway. PBA-1105 increases the autophagic flux of Ub-conjugated aggregates[1].

In Vitro

PBA-1105 induces autophagic degradation of stably expressed mutant tau at DC50 of 0.71 nM and Dmax,24 hr of 100 nM, followed by a hook effect at higher concentrations[1].
PBA-1105 (0.1-10 μM; 24 hours) induces the autophagic degradation of misfolded proteins and aggregates at nanomolar concentrations. PBA-1105 leads to significant degradation of mutant tau and misfolded proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PBA-1105 Related Antibodies

Western Blot Analysis[1]

Cell Line: HEK293T cells
Concentration: 1 μM
Incubation Time: 24 hours
Result: Activated p62 oligomerization and increased autophagic flux of ubiquitinated aggregates.

Western Blot Analysis[1]

Cell Line: SH-SY5Y-tauP301L cells
Concentration: 0.001 μM, 0.01 μM, 0.1 μM, 1 μM, 2.5 μM, 5 μM, 10 μM
Incubation Time: 24 hours
Result: Selectively degraded mutant tauP301L with a DC50 of 0.71 nM and persistently cleared insoluble tau aggregates.
In Vivo

PBA-1105 (20-50 mg/kg; intraperitoneal injection; three times per week; for 4 weeks) successfully reduces tau aggregation and oligomeric species in a transgenic mouse model of tauopathies[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: hTauP301L-BiFC transgenic mice[1]
Dosage: 20 or 50 mg/kg (PBS containing 30% polyethylene glycol (PEG))
Administration: Intraperitoneal injection; three times per week; for 4 weeks
Result: Effectively cleared tau aggregates in a dose-dependent manner, significantly reducing insoluble tau species in the brain while leaving soluble tau species unaffected.
Resulted in increased levels of autophagic markers like LC3, confirming the activation of autophagic degradation pathways.
Immunohistochemical analysis showed a marked reduction in tau oligomers and phosphorylated tau in both cortical and hippocampal regions.
Molecular Weight

640.81

Formula

C39H48N2O6
CAS No.
Appearance

Liquid (Density: 1.129±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(CCCC1=CC=CC=C1)NCCOCCOCCOCCNCC2=CC(OCC3=CC=CC=C3)=C(OCC4=CC=CC=C4)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (156.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5605 mL 7.8026 mL 15.6052 mL
5 mM 0.3121 mL 1.5605 mL 3.1210 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5605 mL 7.8026 mL 15.6052 mL 39.0131 mL
5 mM 0.3121 mL 1.5605 mL 3.1210 mL 7.8026 mL
10 mM 0.1561 mL 0.7803 mL 1.5605 mL 3.9013 mL
15 mM 0.1040 mL 0.5202 mL 1.0403 mL 2.6009 mL
20 mM 0.0780 mL 0.3901 mL 0.7803 mL 1.9507 mL
25 mM 0.0624 mL 0.3121 mL 0.6242 mL 1.5605 mL
30 mM 0.0520 mL 0.2601 mL 0.5202 mL 1.3004 mL
40 mM 0.0390 mL 0.1951 mL 0.3901 mL 0.9753 mL
50 mM 0.0312 mL 0.1561 mL 0.3121 mL 0.7803 mL
60 mM 0.0260 mL 0.1300 mL 0.2601 mL 0.6502 mL
80 mM 0.0195 mL 0.0975 mL 0.1951 mL 0.4877 mL
100 mM 0.0156 mL 0.0780 mL 0.1561 mL 0.3901 mL
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PBA-1105 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PBA-11052410081-56-8PBA1105PBA 1105AUTOTACsAutophagyAUTOphagy-TArgeting ChimerasAUTOTACp62 self-oligomerizationMetAP2Inhibitorinhibitorinhibit

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