2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Calmodulin

Calmodulin

Calmodulin; CaM; Calcium-Modulated Protein

Calmodulin is the highly conserved, calcium-sensitive protein, that acts as the calcium ion sensor in cells, Ca2+-dependently binds to target proteins, and converts Ca2+ concentrations into cellular signals. Calmodulin has four different Ca2+ binding sites named EF-hand for the sensing of Ca2+ signaling with different amplitude, duration, and location. Calmodulin dysfunction could lead to myocardial contractile problems, neuronal damage, or tumor angiogenesis dysregulation, which may cause cardiovascular diseases, neurological diseases, or cancer[1][2][3].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P1805
    Calmodulin Binding Peptide 1
    		Inhibitor
    Calmodulin Binding Peptide 1 is a high affinity (pM) CaM-binding peptide derived from smooth muscle myosin light-chain kinase (MLCK peptide), which strongly inhibits IP3-induced Ca2+ release .
    Calmodulin Binding Peptide 1
  • HY-19015
    Probimane
    		Inhibitor
    Probimane (AT-2153) is a potent anticancer agent. Probimane is effective against mouse tumors S37, S180, Lewis lung carcinoma, L1210 and human pulmonary adenocarcinoma heterotransplanted into nude mice.
    Probimane
  • HY-142087
    Beauverolide Ja
    		Inhibitor
    Beauverolide Ja, a cyclotetradepsipeptide, is a potent calmodulin (CaM) inhibitor with a Kd of 0.078 μM and a Ki of 0.39 μM for Ca2+-CaM. Beauverolide Ja is a secondary metabolite of Isaria fumosorosea.
    Beauverolide Ja
  • HY-N12411
    (S)-O-Methylencecalinol
    		Inhibitor
    (S)-O-Methylencecalinol (compound 10) is a calmodulin-targeting molecule isolated from the aerial parts of Ageratina grandifolia.
    (S)-O-Methylencecalinol
  • HY-N12405
    Encecalinol
    		Inhibitor
    Encecalinol, extracted from aerial parts of Ageratina grandifolia, is a potent inhibitor of calmodulin inhibitor.
    Encecalinol
  • HY-106645
    Cloxacepride
    		Antagonist
    Cloxacepride is an orally active and potent antiallergic agent. Cloxacepride is a CaM (calmodulin) antagonist. Cloxacepride has anti-PCA (passive cutaneous anaphylaxis) activity.
    Cloxacepride
  • HY-P5424
    RyR1(3614-3643)
    RyR1(3614-3643) is a biological active peptide. (the absolutely conserved peptide corresponding to the CaM-binding domain of RyR1 in all vertebrates)
    RyR1(3614-3643)
  • HY-16129
    CBP-501
    CBP-501 is a cell-permeable and calmodulin-binding peptide that enhances the influx of platinum agents into tumor cells and tumor immunogenicity. CBP-501 can be utilized in cancer research.
    CBP-501
  • HY-P1874
    Calmodulin-Dependent Protein Kinase II (281-309)
    		Inhibitor
    Calmodulin-Dependent Protein Kinase II (281-309) is a peptide of calcium/calmodulin-dependent protein kinase II (CaM-kinase II).
    Calmodulin-Dependent Protein Kinase II (281-309)
  • HY-19025
    CV-159
    		Antagonist
    CV-159 is a unique dihydropyridine Ca2+ antagonist with an anti-calmodulin (CaM) action, and has antiinflammatory activities.
    CV-159
  • HY-P1077
    CALP1
    		Agonist
    CALP1 is a calmodulin (CaM) agonist (Kd of 88 µM) with binding to the CaM EF-hand/Ca2+-binding site. CALP1 blocks calcium influx and apoptosis (IC50 of 44.78 µM) through inhibition of calcium channel opening. CALP1 blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 activates CaM-dependent phosphodiesterase activity.
    CALP1
  • HY-P10165
    MLCK Peptide
    MLCK Peptide is a fully reversible, high affinity (pM) CaM-binding peptide derived from smooth muscle myosin light-chain kinase.
    MLCK Peptide
  • HY-120997
    E6 Berbamine
    		Antagonist
    E6 Berbamine (Berbamine p-nitrobenzoate) is a potent calmodulin (CaM) antagonist. E6 Berbamine inhibits the activity of calmodulin (CaM)-dependent myosin light chain kinase (MLCK), with a Ki of 0.95 μM. E6 Berbamine also shows anti-leukemia activities, with an IC50 of 2.13 μM in K562 cells.
    E6 Berbamine
  • HY-125412
    Fasciculic acid B
    		Antagonist
    Fasciculic acid B is a steroid that can be isolated from Hypholoma lateritium. Fasciculic acid B has antiinflammatory and calmodulin antagonistic activity.
    Fasciculic acid B
  • HY-N7733
    Fasciculic acid A
    		Antagonist
    Fasciculic acid A is a steroid that can be isolated from Hypholoma lateritium. Fasciculic acid B has antiinflammatory and calmodulin antagonistic activity.
    Fasciculic acid A
  • HY-125449
    Fasciculic acid C
    		Antagonist
    Fasciculic acid C is a calmodulin antagonist that can be isolated from mushroom Naematoloma fasciculare.
    Fasciculic acid C
  • HY-106745
    Elziverine
    		Antagonist
    Elziverine (Ro 22-4839) is a brain circulation improvement agent with vasospasm antispasmodic effects. Elziverine is a calmodulin antagonist. Elziverine inhibits erythrocyte cell membrane rupture, platelet aggregation and lipid peroxidation.
    Elziverine
  • HY-137045
    Bisindolylmaleimide VII
    		Inhibitor
    Bisindolylmaleimide VII is a potent inhibitor of calmodulin with high affinity for calmodulin (Kd=186.2 nM). Bisindolylmaleimide VII is used to study the role of calmodulin in cancer, neurodegenerative diseases, and muscle dysfunction.
    Bisindolylmaleimide VII
  • HY-100263B
    Metofenazate (diethanesulfonate)
    		Inhibitor
    Metofenazate diethanesulfonate is a selective calmodulin inhibitor.
    Metofenazate (diethanesulfonate)
Cat. No. Product Name / Synonyms Application Reactivity