2. Signaling Pathways
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  4. Drug Derivative

Drug Derivative

Drug derivative

Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.

Drug Derivative Related Products (1330):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-122682
    SBI-993
    		98.67%
    SBI-993 is a SBI-477 analog with improved potency and suitable pharmacokinetic properties for in vivo bioavailability. SBI-993 stimulates insulin signaling by deactivating the transcription factor MondoA.
    SBI-993
  • HY-W011053
    Neotame
    		98.00%
    Neotame is a derivative of Aspartame (HY-B0361) and is a flavor enhancer and low-caloric, non-nutritive, high-intensity artificial sweetener that is 7000-13,000 times sweeter than sugar. Neotame causes intestinal epithelial cell death at high concentrations. Neotame induces Apoptosis of Caco-2 cells.
    Neotame
  • HY-B2102
    Oxyphenisatine
    		98.42%
    Oxyphenisatine (Oxyphenisatin) is a laxative. Oxyphenisatin acetate is the pro-agent of oxyphenisatin with anticancer activity.
    Oxyphenisatine
  • HY-P0170
    TB500
    		99.48%
    TB500 is a synthetic version of an active region of thymosin β4. TB500 exhibits anti-fibrotic and wound healing activities by inhibiting the Akt signaling pathway and binding to actin. TB500 is claimed to promote endothelial cell differentiation, angiogenesis in dermal tissues, keratinocyte migration, collagen deposition and decrease inflammation.
    TB500
  • HY-W016321
    N-Benzylaniline
    		99.88%
    N-Benzylaniline (N-Phenylbenzylamine) is an N-alkyl­ated derivative of aniline.
    N-Benzylaniline
  • HY-N0097A
    9-β-D-Arabinofuranosylguanine
    		99.24%
    9-β-D-Arabinofuranosylguanine is a Guanosine (HY-N0097) analog and shows high affinity for deoxyguanosine kinase (dGK) with a Km of 8.0 μM. 9-β-D-Arabinofuranosylguanine can be used for the research of T-cell lymphoblastic disease.
    9-β-D-Arabinofuranosylguanine
  • HY-139409A
    2-Deoxy-D-glucose 6-phosphate disodium
    		≥98.0%
    2-Deoxy-D-glucose 6-phosphate disodium, a derivative of 2-Deoxy-D-glucose, is produced in mammalian cells by the action of hexokinase on 2-DG. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase.
    2-Deoxy-D-glucose 6-phosphate disodium
  • HY-136506
    NUC-7738
    NUC-7738, an aryloxy phosphoramidate of 3′-Deoxyadenosine, is a 5′-aryloxy phosphoramidate prodrug of 3′-Deoxyadenosine (3′-dA). NUC-7738 has potent cytotoxic activity against a panel of hematological cancer cell lines. NUC-7738 can be used in research of cancer.
    NUC-7738
  • HY-160429
    PSAR18-COOH
    		99.86%
    PSAR18-COOH is a derivative of PSAR extracted from patent WO2009064913A1. PSAR is a highly hydrophilic, biodegradable, non-immunogenic and water-soluble polymer that has been employed in several delivery systems for drugs or diagnostics.
    PSAR18-COOH
  • HY-B2212
    Dibenzoyl Thiamine
    		99.83%
    Dibenzoyl Thiamine (Bentiamine), a derivative of thiamine, is rapidly absorbed into the body and converted to thiamine.
    Dibenzoyl Thiamine
  • HY-41982
    D-Glucuronic acid lactone
    		≥98.0%
    D-Glucuronic acid lactone (D-Glucurono-6,3-lactone) is an endogenous metabolite, which is a glucuronic acid derivative. D-Glucuronic acid lactone can be used as starting regents in the synthesis of 2,3,4,-tris(tert.-butyldimethysilyl) glucuronic acid trichloroethylester, requirement for the preparation of 1-O-acyl glucuronide of the anti-inflammatory agent ML-3000 (HY-B1452), synthesis of optically active glucopyranoses, synthesis of long-chain alkyl glucofuranosides. D-Glucuronic acid lactone is promising for research of reversible cerebral vasoconstriction syndrome (RCVS).
    D-Glucuronic acid lactone
  • HY-W005627
    Linoleyl alcohol
    		99.84%
    Linoleyl alcohol, a structural analog of Linoleic acid with no a-carboxyl group, is a fatty alcohol.
    Linoleyl alcohol
  • HY-W111581
    Copper(II) diethyldithiocarbamate
    		98.6%
    Copper(II) diethyldithiocarbamate has anticancer activity. Copper(II) diethyldithiocarbamate can be synthesized from monovalent copper-cysteamine and disulfiram.
    Copper(II) diethyldithiocarbamate
  • HY-128775
    JHU395
    		99.88%
    JHU395 is an orally-bioavailable and a plasma stable lipophilic glutamine antagonists (GA) proagent. JHU395 delivers 6-diazo-5-oxo-L-norleucine (DON) to malignant peripheral nerve sheath tumor (MPNST) in vitro and in vivo, and has antitumor activity in MPNST.
    JHU395
  • HY-129430
    N-Methylprotoporphyrin IX
    		≥99.0%
    N-Methylprotoporphyrin IX is a potent inhibitor of ferrochelatase enzyme.
    N-Methylprotoporphyrin IX
  • HY-111179
    ML261
    		99.80%
    ML261 is a hepatic lipid droplets formation inhibitor with an IC50 value of 69.7 nM. ML261 can be used for the research of non-alcoholic fatty liver disease (NAFLD) and inflammation.
    ML261
  • HY-13769A
    TPT-260 Dihydrochloride
    		≥98.0%
    TPT-260 Dihydrochloride (NSC55712) is a thiourea derivative.
    TPT-260 Dihydrochloride
  • HY-141490
    Beta-D-Glucopyranosyl nitromethane
    		99.94%
    Beta-D-Glucopyranosyl nitromethane, as a salt of a strongly basic anion exchanger in the OH cycle, is a glycosyl derivative of nitromethane.
    Beta-D-Glucopyranosyl nitromethane
  • HY-B1785
    5-Sulfosalicylic acid
    5-Sulfosalicylic acid is a sulfonated salicylic acid derivative. 5-Sulfosalicylic acid is effective against the breast cancer cell lines, with less toxicity. 5-Sulfosalicylic acid has antioxidant activities.
    5-Sulfosalicylic acid
  • HY-12424
    Zotarolimus
    		≥98.0%
    Zotarolimus (ABT-578) is a derivative of Rapamycin (HY-10219), with anti-proliferative activity. Zotarolimus is an immunosuppressant. Zotarolimus is developed specifically for local delivery from stents for the prevention of coronary artery restenosis.
    Zotarolimus