2. Signaling Pathways
  3. Apoptosis
    Autophagy
    Cell Cycle/DNA Damage
    Immunology/Inflammation
  4. FKBP
  5. FKBP Degrader

FKBP Degrader

FKBP Degraders (5):

Cat. No. Product Name Effect Purity
  • HY-163807
    22-SLF
    		Degrader
    22-SLF is a PROTAC degrader, that degrades FK506-binding protein 12 (FKBP12) with a DC50 of 0.5 µM in a FBXO22 dependent manner. 22-SLF degrades other endogenous proteins, such as BRD4 and EML4-ALK fusion protein.(Pink: Ligand for target protein SLF (HY-114872); Black: Linker (HY-163821); Blue: Ligand for E3 ligase (HY-163826)).
  • HY-161794
    SP3N
    		Degrader
    SP3N is a specific degrader of proline isomerase FKBP12, which is metabolized by amine oxidase to a precursor of the active aldehyde (SP3CHO), which recruits SCFFBXO22 ligase for FKBP12 degradation. SP3N can be used in cancer therapy research.
  • HY-169148
    YT117R
    		Degrader
    YT117R is a PROTAC degrader of FKBP12 and Pink: Target protein ligand: (HY-158301); Black: linker (HY-42776); Blue: E3 ligase ligand (HY-78695)).
  • HY-114421
    FKBP12 PROTAC dTAG-13
    		Degrader 99.75%
    FKBP12 PROTAC dTAG-13 (dTAG-13), a PROTAC-based heterobifunctional degrader, is a selective degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 effectively engages FKBP12F36V and CRBN, thereby selectively degrading FKBP12F36V.
  • HY-145514C
    dTAGV-1 hydrochloride
    		Degrader 98.83%
    dTAGV-1 hydrochloride is the hydrochloride form of dTAGV-1 that is a small molecule degrader of FKBP12.