2. Immunology/Inflammation Stem Cell/Wnt Cell Cycle/DNA Damage
  3. IKZF Family Casein Kinase
  4. MGD-28

MGD-28 is a potent, orally active, Cereblon (CRBN)-dependent IKAROS protein degrader that degrades IKZF1 (DC50=3.8 nM), IKZF2 (DC50=56.3 nM), and IKZF3 (DC50=7.1 nM) in a dose-dependent manner. In addition, MGD-4 also degrades CK1α (DC50=7.8 nM). MGD-28 has antiproliferative activity and can be used in multiple myeloma research.

For research use only. We do not sell to patients.

MGD-28 Chemical Structure

MGD-28 Chemical Structure

CAS No. : 2991818-13-2

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MGD-28 Related Antibodies

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IKZF1 IKZF2 IKZF3

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CK1 CK2

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Description

MGD-28 is a potent, orally active, Cereblon (CRBN)-dependent IKAROS protein degrader that degrades IKZF1 (DC50=3.8 nM), IKZF2 (DC50=56.3 nM), and IKZF3 (DC50=7.1 nM) in a dose-dependent manner. In addition, MGD-4 also degrades CK1α (DC50=7.8 nM). MGD-28 has antiproliferative activity and can be used in multiple myeloma research[1].

IC50 & Target[1]

IKZF1

3.8 nM (DC50)

IZKF2

56.3 nM (DC50)

IKZF3

7.1 nM (DC50)

CK1α

7.8 nM (DC50)

Molecular Weight

595.67

Formula

C33H34FN7O3
CAS No.
SMILES

CN(N(C1C(NC(CC1)=O)=O)C2=O)CC(C2=CC=C3)=C3NCC(C=C4)=CC=C4CN(CC5)CCN5C6=CC(F)=C(C#N)C=C6
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MGD-28 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MGD-282991818-13-2MGD28MGD 28IKZF FamilyCasein KinaseOral activereducing agentmultiple myelomaanti-proliferationInhibitorinhibitorinhibit

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