2. Immunology/Inflammation
  3. IKZF Family
  4. MGD-4

MGD-4 is an orally active, Cereblon (CRBN)-dependent IKAROS protein degrader that degrades IKZF1 (DC50=67.2 nM), IKZF2 (DC50=918.2 nM), and IKZF3 (DC50=95.8 nM) in a dose-dependent manner. MGD-4 effectively inhibits the growth of multiple myeloma.

For research use only. We do not sell to patients.

MGD-4 Chemical Structure

MGD-4 Chemical Structure

CAS No. : 2991817-99-1

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MGD-4 Related Antibodies

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IKZF1 IKZF2 IKZF3

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Description

MGD-4 is an orally active, Cereblon (CRBN)-dependent IKAROS protein degrader that degrades IKZF1 (DC50=67.2 nM), IKZF2 (DC50=918.2 nM), and IKZF3 (DC50=95.8 nM) in a dose-dependent manner. MGD-4 effectively inhibits the growth of multiple myeloma[1].

IC50 & Target[1]

IKZF1

67.2 nM (DC50)

IZKF2

918.2 nM (DC50)

IKZF3

95.8 nM (DC50)

Molecular Weight

288.30

Formula

C14H16N4O3
CAS No.
SMILES

O=C1N(C2C(NC(CC2)=O)=O)N(C)CC3=C(N)C=CC=C31
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MGD-4 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MGD-42991817-99-1MGD4MGD 4IKZF Family降解剂，剂量依赖性，多发性骨髓瘤，口服活血Inhibitorinhibitorinhibit

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