2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Lipase

Lipase

Lipase is a water-soluble enzyme that can catalyze the ester bond hydrolysis of lipids, decompose and metabolize fat molecules. Lipase is produced primarily by the pancreas and helps the body digest fats and oils. Lipase inhibitors are able to reduce the digestion and absorption of fat, thereby reducing collective caloric intake and weight loss. Lipase inhibitors are commonly used to suppress diseases such as obesity, hyperlipidemia, and pancreatitis.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-126564
    Ebelactone A
    		Inhibitor
    Ebelactone A is a mycolic acid β-lactone, which exhibits inhibitory activity for esterase, lipase, fMet aminopeptidase (fMet AP) and PNBase, with IC50s of 56, 3, 8 and 7.5 μM, respectively. Ebelactone A inhibits cutinase, exhibits plants protective potency against Erysiphe graminis.
    Ebelactone A
  • HY-135996A
    Dilaurylglycerosulfate sodium
    		99.85%
    Dilaurylglycerosulfate sodium is a co-emulsifier in the diagnostic test for the determination of lipase.
    Dilaurylglycerosulfate sodium
  • HY-Y1422K
    Lipase PS-IM
    Lipase PS-IM is an immobilized lipase derived from Burkholderiacepacia.
    Lipase PS-IM
  • HY-157741
    1-Myristoyl-2-oleoyl-3-palmitoyl-rac-glycerol
    1-Myristoyl-2-oleoyl-3-palmitoyl-rac-glycerol (MOP) is a triacylglycerol containing myristic acid (HY-N2041), oleic acid (HY-N1446) and palmitic acid (HY-N0830) at the sn-1, sn-2 and sn-3 positions, respectively.
    1-Myristoyl-2-oleoyl-3-palmitoyl-rac-glycerol
  • HY-N12298
    Ciwujianoside C1
    		Inhibitor
    Ciwujianoside C1 is a saponin, that can be isolated from the leaves of Acanthopanax senticosus. Ciwujianoside C1 inhibits pancreatic lipase activity in vitro.
    Ciwujianoside C1
  • HY-19861
    SMP-028
    		Inhibitor
    SMP-028 is an inhibitor of neutral cholesterol esterase (CEase), with an IC50 of 1.01 μM.
    SMP-028
  • HY-Y1422I
    Lipase AK
    Lipase AK comes from Pseudomonas fluorescens and shows good applicability in ester synthesis of food industry, the biofuel synthesis, the synthesis of enantiomeric pure chiral drugs and so on.
    Lipase AK
  • HY-14471R
    Cetilistat (Standard)
    		Inhibitor
    Cetilistat (Standard) is the analytical standard of Cetilistat. This product is intended for research and analytical applications. Cetilistat (ATL-962), an inhibitor of pancreatic lipase, acts as an effective anti-obesity agent. Cetilistat inhibits rat and human pancreatic lipase activity with IC50s of 54.8 nM, and 5.95 nM, respectively.
    Cetilistat (Standard)
  • HY-N8362
    1-Isomangostin
    		Inhibitor
    1-Isomangostin is an inhibitor of pancreatic lipase. 1-Isomangostin inhibits porcine pancreatic lipase with an IC50 of 34.5 μM. 1-Isomangostin has anti-obesity activity.
    1-Isomangostin
  • HY-149506
    1,3-Didecanoylglycerol
    1,3-Didecanoylglycerol (1,3-Dicaprin) is a triglyceride analog that can be used as a substrate in pancreatic lipase hydrolysis reactions.
    1,3-Didecanoylglycerol
  • HY-N12893
    Sclerodione
    		Inhibitor
    Sclerodione is a metabolite that can be produced by the Scleroderris canker fungus, Gremmeniellaabietina. Sclerodione has antifungal activity. Sclerodione is a lipase inhibitor (IC50: 1 μM).
    Sclerodione
  • HY-114754
    BemPPOX
    		Inhibitor
    BemPPOX is an orally active, potent dog gastric lipase (DGL) inhibitor with Xl50 (the inhibitor molar excess leading to 50% lipase inhibition) of 0.5. BemPPOX is also a good inhibitor of GPLRP2 (xl50=0.64). BemPPOX efficiently regulates the gastrointestinal lipolysis and slows down the overall lipolysis process in rats. BemPPOX has the potential for obesity research.
    BemPPOX
  • HY-N2087
    Ligupurpuroside A
    		Inhibitor
    Ligupurpuroside A is an active product that can be extracted from Ligustrum robustum. Ligupurpuroside A acts as a natural inhibitor of lipase in a competitive manner.
    Ligupurpuroside A
  • HY-N0555R
    Escin IB (Standard)
    		Inhibitor
    Escin IB (Standard) is the analytical standard of Escin IB. This product is intended for research and analytical applications. Escin IB is a saponin isolated from skin and the endosperm of seeds of horse chestnut (Aesculus hippocastanum). Escin IB shows inhibitory effect on pancreatic lipase activity.
    Escin IB (Standard)
  • HY-N7859
    1,3-Dioleoyl-2-myristoyl glycerol
    1,3-Dioleoyl-2-myristoyl glycerol is a triacylglycerol that contains oleic acid at the sn-1 and sn-3 positions and myristic acid at the sn-2 position.
    1,3-Dioleoyl-2-myristoyl glycerol
  • HY-119741
    Salacinol
    		Inhibitor
    Salacinol can be isolated from the roots of the plant Salacia reticulata. Salacinol inhibits fat metabolizing enzymes, such as pancreatic lipase (PL, IC50=12.6 mg/L), lipoprotein lipase (LPL, IC50=13.6 mg/L), and glycerophosphate dehydrogenase (GPDH), enhances the lipolysis, and exhibits antiobesity efficacy in rats.
    Salacinol
  • HY-157313
    Pancreatic lipase-IN-1
    		Inhibitor
    Pancreatic lipase-IN-1 (compound 8) ia a pancreatic lipase inhibitor with the Ki of 1.288 μM.
    Pancreatic lipase-IN-1
Cat. No. Product Name / Synonyms Application Reactivity