2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Lipase

Lipase

Lipase is a water-soluble enzyme that can catalyze the ester bond hydrolysis of lipids, decompose and metabolize fat molecules. Lipase is produced primarily by the pancreas and helps the body digest fats and oils. Lipase inhibitors are able to reduce the digestion and absorption of fat, thereby reducing collective caloric intake and weight loss. Lipase inhibitors are commonly used to suppress diseases such as obesity, hyperlipidemia, and pancreatitis.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N12294
    Ciwujianoside D2
    		Activator
    Ciwujianoside D2, a saponin compound, can enhance pancreatic lipase activity in vitro.
    Ciwujianoside D2
  • HY-123862
    LAS195319
    		Inhibitor
    LAS195319 is an orally active and potent inhibitor against PI3Kδ with an IC50 value of 0.5 nM. LAS195319 is also a highly selective inhibitor against an extensive panel of proteins, lipid kinases and GPCRs. LAS195319 causes an inhibition of neutrophil and eosinophil infiltration. LAS195319 is promising for research of respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD).
    LAS195319
  • HY-138653
    Lipase Substrate
    Lipase Substrate is a substrate of lipase to detect activity.
    Lipase Substrate
  • HY-N12296
    Ciwujianoside C4
    		Activator
    Ciwujianoside C4, a saponin compound, can enhance pancreatic lipase activity in vitro.
    Ciwujianoside C4
  • HY-N8989
    (1,5E,11E)-Tridecatriene-7,9-diyne-3,4-diacetate
    		Inhibitor
    (1,5E,11E)-Tridecatriene-7,9-diyne-3,4-diacetate, isolated from the ethanol extract of Atractylodes lancea rhizome, displays significant lipase inhibition with an IC50 value of 23.9 µg/mL. Antiobesity Effect.
    (1,5E,11E)-Tridecatriene-7,9-diyne-3,4-diacetate
  • HY-157534
    Pancreatic lipase-IN-2
    Pancreatic lipase-IN-2 (compound 7r) is a potent inhibitor of pancreatic lipase (PL), with the IC50 value of 2.67 μM, that has anti-obesity effect.
    Pancreatic lipase-IN-2
  • HY-Y1422H
    Lipase AYS
    Lipase AYS is an immobilized lipase derived from Candida rugosa.
    Lipase AYS
  • HY-126564
    Ebelactone A
    		Inhibitor
    Ebelactone A is a mycolic acid β-lactone, which exhibits inhibitory activity for esterase, lipase, fMet aminopeptidase (fMet AP) and PNBase, with IC50s of 56, 3, 8 and 7.5 μM, respectively. Ebelactone A inhibits cutinase, exhibits plants protective potency against Erysiphe graminis.
    Ebelactone A
  • HY-135996A
    Dilaurylglycerosulfate sodium
    		99.85%
    Dilaurylglycerosulfate sodium is a co-emulsifier in the diagnostic test for the determination of lipase.
    Dilaurylglycerosulfate sodium
  • HY-Y1422K
    Lipase PS-IM
    Lipase PS-IM is an immobilized lipase derived from Burkholderiacepacia.
    Lipase PS-IM
  • HY-157741
    1-Myristoyl-2-oleoyl-3-palmitoyl-rac-glycerol
    1-Myristoyl-2-oleoyl-3-palmitoyl-rac-glycerol (MOP) is a triacylglycerol containing myristic acid (HY-N2041), oleic acid (HY-N1446) and palmitic acid (HY-N0830) at the sn-1, sn-2 and sn-3 positions, respectively.
    1-Myristoyl-2-oleoyl-3-palmitoyl-rac-glycerol
  • HY-N12298
    Ciwujianoside C1
    		Inhibitor
    Ciwujianoside C1 is a saponin, that can be isolated from the leaves of Acanthopanax senticosus. Ciwujianoside C1 inhibits pancreatic lipase activity in vitro.
    Ciwujianoside C1
  • HY-19861
    SMP-028
    		Inhibitor
    SMP-028 is an inhibitor of neutral cholesterol esterase (CEase), with an IC50 of 1.01 μM.
    SMP-028
  • HY-14471R
    Cetilistat (Standard)
    		Inhibitor
    Cetilistat (Standard) is the analytical standard of Cetilistat. This product is intended for research and analytical applications. Cetilistat (ATL-962), an inhibitor of pancreatic lipase, acts as an effective anti-obesity agent. Cetilistat inhibits rat and human pancreatic lipase activity with IC50s of 54.8 nM, and 5.95 nM, respectively.
    Cetilistat (Standard)
  • HY-N8362
    1-Isomangostin
    		Inhibitor
    1-Isomangostin is an inhibitor of pancreatic lipase. 1-Isomangostin inhibits porcine pancreatic lipase with an IC50 of 34.5 μM. 1-Isomangostin has anti-obesity activity.
    1-Isomangostin
  • HY-149506
    1,3-Didecanoylglycerol
    1,3-Didecanoylglycerol (1,3-Dicaprin) is a triglyceride analog that can be used as a substrate in pancreatic lipase hydrolysis reactions.
    1,3-Didecanoylglycerol
  • HY-N12893
    Sclerodione
    		Inhibitor
    Sclerodione is a metabolite that can be produced by the Scleroderris canker fungus, Gremmeniellaabietina. Sclerodione has antifungal activity. Sclerodione is a lipase inhibitor (IC50: 1 μM).
    Sclerodione
  • HY-114754
    BemPPOX
    		Inhibitor
    BemPPOX is an orally active, potent dog gastric lipase (DGL) inhibitor with Xl50 (the inhibitor molar excess leading to 50% lipase inhibition) of 0.5. BemPPOX is also a good inhibitor of GPLRP2 (xl50=0.64). BemPPOX efficiently regulates the gastrointestinal lipolysis and slows down the overall lipolysis process in rats. BemPPOX has the potential for obesity research.
    BemPPOX
  • HY-N2087
    Ligupurpuroside A
    		Inhibitor
    Ligupurpuroside A is an active product that can be extracted from Ligustrum robustum. Ligupurpuroside A acts as a natural inhibitor of lipase in a competitive manner.
    Ligupurpuroside A
  • HY-N14641
    Panclicin A
    		Inhibitor
    Panclicin A is a potent pancreatic lipase inhibitor.
    Panclicin A
Cat. No. Product Name / Synonyms Application Reactivity