2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Lipase

Lipase

Lipase is a water-soluble enzyme that can catalyze the ester bond hydrolysis of lipids, decompose and metabolize fat molecules. Lipase is produced primarily by the pancreas and helps the body digest fats and oils. Lipase inhibitors are able to reduce the digestion and absorption of fat, thereby reducing collective caloric intake and weight loss. Lipase inhibitors are commonly used to suppress diseases such as obesity, hyperlipidemia, and pancreatitis.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-165039
    1,3-Dioleoyl-2-octanoyl glycerol
    1,3-Dioleoyl-2-octanoyl glycerol (1,3-Olein-2-caprylin) is a triacylglycerol. 1,3-Dioleoyl-2-octanoyl glycerol can be used to characterize the functionality of R. oryzae lipase for regiodistribution analysis of fats containing medium- and short-chain fatty acids.
    1,3-Dioleoyl-2-octanoyl glycerol
  • HY-B1393R
    Dehydrocholic acid (Standard)
    		Inhibitor
    Dehydrocholic acid (Dehydrocholate) (Standard) is the analytical standard of Dehydrocholic acid (HY-B1393). This product is intended for research and analytical applications. Dehydrocholic acid (Dehydrocholate) is an orally active hydrocholeretic agent. Dehydrocholic acid modulates Autophagy, reduces serum amylase and lipase levels. Dehydrocholic acid has the effects of promoting choleretic function, protecting the liver, reducing pancreatic damage, and regulating cholesterol metabolism. Dehydrocholic acid can be used in the study of acute biliary pancreatitis and obstructive jaundice.
    Dehydrocholic acid (Standard)
  • HY-W010505S
    Hexane-1,6-diol-d4
    		Substrate
    Hexane-1,6-diol-d4 is the deuterium labeled Hexane-1,6-diol (HY-W010505). Hexane-1,6-diol is a 6-carbon straight-chain diol with hydroxyl groups at both ends. Hexane-1,6-diol can be used as an additive for drilling fluids. Hexane-1,6-diol can also be used as a substrate in life science-related research.
    Hexane-1,6-diol-d<sub>4</sub>
  • HY-Y1422J
    Lipase,Burkholderiacepacia (Immobilized)
    Lipase,Burkholderiacepacia (Immobilized) comes from Burkholderiacepacia and can be used for catalytic reaction.
    Lipase,Burkholderiacepacia (Immobilized)
  • HY-157733
    1,2-Dioleoyl-3-behenoylglycerol
    		Inhibitor
    1,2-Dioleoyl-3-behenoylglycerol (BOO) inhibits pancreatic lipase activity. 1,2-Dioleoyl-3-behenoylglycerol prevents the deposition of visceral fat and hepatic triacylglycerol (TAG).
    1,2-Dioleoyl-3-behenoylglycerol
  • HY-N12294
    Ciwujianoside D2
    		Inhibitor
    Ciwujianoside D2, a saponin compound, can enhance pancreatic lipase activity in vitro.
    Ciwujianoside D2
  • HY-N12294
    Ciwujianoside D2
    		Activator
    Ciwujianoside D2, a saponin compound, can enhance pancreatic lipase activity in vitro.
    Ciwujianoside D2
  • HY-123862
    LAS195319
    		Inhibitor
    LAS195319 is an orally active and potent inhibitor against PI3Kδ with an IC50 value of 0.5 nM. LAS195319 is also a highly selective inhibitor against an extensive panel of proteins, lipid kinases and GPCRs. LAS195319 causes an inhibition of neutrophil and eosinophil infiltration. LAS195319 is promising for research of respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD).
    LAS195319
  • HY-138653
    Lipase Substrate
    Lipase Substrate is a substrate of lipase to detect activity.
    Lipase Substrate
  • HY-N12296
    Ciwujianoside C4
    		Activator
    Ciwujianoside C4, a saponin compound, can enhance pancreatic lipase activity in vitro.
    Ciwujianoside C4
  • HY-N8989
    (1,5E,11E)-Tridecatriene-7,9-diyne-3,4-diacetate
    		Inhibitor
    (1,5E,11E)-Tridecatriene-7,9-diyne-3,4-diacetate, isolated from the ethanol extract of Atractylodes lancea rhizome, displays significant lipase inhibition with an IC50 value of 23.9 µg/mL. Antiobesity Effect.
    (1,5E,11E)-Tridecatriene-7,9-diyne-3,4-diacetate
  • HY-157534
    Pancreatic lipase-IN-2
    Pancreatic lipase-IN-2 (compound 7r) is a potent inhibitor of pancreatic lipase (PL), with the IC50 value of 2.67 μM, that has anti-obesity effect.
    Pancreatic lipase-IN-2
  • HY-126564
    Ebelactone A
    		Inhibitor
    Ebelactone A is a mycolic acid β-lactone, which exhibits inhibitory activity for esterase, lipase, fMet aminopeptidase (fMet AP) and PNBase, with IC50s of 56, 3, 8 and 7.5 μM, respectively. Ebelactone A inhibits cutinase, exhibits plants protective potency against Erysiphe graminis.
    Ebelactone A
  • HY-N2330R
    Lipstatin (Standard)
    		Inhibitor
    Ginsenoside F2 (Standard) is the analytical standard of Ginsenoside F2. This product is intended for research and analytical applications. Ginsenoside F2, a metabolite from Ginsenoside Rb1, induces apoptosis accompanied by protective autophagy in breast cancer stem cells.
    Lipstatin (Standard)
  • HY-135996A
    Dilaurylglycerosulfate sodium
    		99.85%
    Dilaurylglycerosulfate sodium is a co-emulsifier in the diagnostic test for the determination of lipase.
    Dilaurylglycerosulfate sodium
  • HY-157741
    1-Myristoyl-2-oleoyl-3-palmitoyl-rac-glycerol
    1-Myristoyl-2-oleoyl-3-palmitoyl-rac-glycerol (MOP) is a triacylglycerol containing myristic acid (HY-N2041), oleic acid (HY-N1446) and palmitic acid (HY-N0830) at the sn-1, sn-2 and sn-3 positions, respectively.
    1-Myristoyl-2-oleoyl-3-palmitoyl-rac-glycerol
  • HY-N12298
    Ciwujianoside C1
    		Inhibitor
    Ciwujianoside C1 is a saponin, that can be isolated from the leaves of Acanthopanax senticosus. Ciwujianoside C1 inhibits pancreatic lipase activity in vitro.
    Ciwujianoside C1
  • HY-19861
    SMP-028
    		Inhibitor
    SMP-028 is an inhibitor of neutral cholesterol esterase (CEase), with an IC50 of 1.01 μM.
    SMP-028
  • HY-173599
    NUV-244
    		Degrader
    NUV-244 is a PNPLA3 I148M degrader. NUV-244 reduces PNPLA3 I148M levels on lipid droplets via BFAR-mediated ubiquitin-proteasome degradation.
    NUV-244
  • HY-14471R
    Cetilistat (Standard)
    		Inhibitor
    Cetilistat (Standard) is the analytical standard of Cetilistat. This product is intended for research and analytical applications. Cetilistat (ATL-962), an inhibitor of pancreatic lipase, acts as an effective anti-obesity agent. Cetilistat inhibits rat and human pancreatic lipase activity with IC50s of 54.8 nM, and 5.95 nM, respectively.
    Cetilistat (Standard)
Cat. No. Product Name / Synonyms Application Reactivity