Lipase Inhibitor

Lipase Inhibitors (37):

Cat. No.	Product Name	Effect	Purity

HY-101509

HSL-IN-1	Inhibitor	98.84%
HSL-IN-1 (compound 24b) is a potent and orally active hormone sensitive lipase (HSL) inhibitor (IC₅₀=2 nM) with a significantly reduced reactive metabolite liability.

HY-153523

Hi 76-0079	Inhibitor	99.90%
Hi 76-0079 (Compound 31) is a hormone-sensitive lipase (HSL) inhibitor with an IC₅₀ of 184 nM.

HY-164714

HSL-IN-5	Inhibitor	99.83%
HSL-IN-5 (Example 21) is a hormone sensitive lipase (HSL) inhibitor (IC₅₀: 0.25 μM). HSL-IN-5 can be used for diabetes research.

HY-N2330R

Lipstatin (Standard)	Inhibitor
Ginsenoside F2 (Standard) is the analytical standard of Ginsenoside F2. This product is intended for research and analytical applications. Ginsenoside F2, a metabolite from Ginsenoside Rb1, induces apoptosis accompanied by protective autophagy in breast cancer stem cells.

HY-114754

BemPPOX	Inhibitor
BemPPOX is an orally active, potent dog gastric lipase (DGL) inhibitor with X_l50 (the inhibitor molar excess leading to 50% lipase inhibition) of 0.5. BemPPOX is also a good inhibitor of GPLRP2 (x_l50=0.64). BemPPOX efficiently regulates the gastrointestinal lipolysis and slows down the overall lipolysis process in rats. BemPPOX has the potential for obesity research.

HY-102056

BAY 59-9435	Inhibitor	99.75%
BAY 59-9435 is a potent and selective inhibitor of Hormone Sensitive Lipase (HSL), with an IC₅₀ of 0.023 μM.

HY-23524

HSL-IN-3	Inhibitor	≥98.0%
HSL-IN-3 (example 42), a boronic acid ester derivative, is an inhibitor of hormone-sensitive lipase (HSL).

HY-N0777

Isorhamnetin-3-O-glucoside	Inhibitor	99.95%
Isorhamnetin-3-O-glucoside is an orally active natural compound. Isorhamnetin 3-O-glucoside increases P-ERK, ERK, P-Akt (Ser473), P-PI3K, and PDX-1. Isorhamnetin 3-O-glucoside downregulates C/EBPα and inhibits lipase. Isorhamnetin 3-O-glucoside reduces lipids and inhibits obesity.

HY-103372

GSK264220A	Inhibitor	99.24%
GSK264220A is a potent endothelial lipase inhibitor with IC₅₀ of 16 nM. GSK264220A has the potential to decrease the risk of cardiovascular disease.

HY-14471

Cetilistat	Inhibitor	≥98.0%
Cetilistat (ATL-962), an inhibitor of pancreatic lipase, acts as an effective anti-obesity agent. Cetilistat inhibits rat and human pancreatic lipase activity with IC₅₀s of 54.8 nM, and 5.95 nM, respectively.

HY-N6667

Glucovanillin	Inhibitor	99.87%
Glucovanillin, found in vanilla, is a potential lipase inhibitor. Glucovanillin can be converted into vanillin through an enzyme-coupled process involving cell wall degradation and glucovanillin hydrolysis.

HY-N0555

Escin IB	Inhibitor	99.93%
Escin IB is a saponin isolated from skin and the endosperm of seeds of horse chestnut (Aesculus hippocastanum). Escin IB shows inhibitory effect on pancreatic lipase activity.

HY-N7668

Neotheaflavin	Inhibitor	99.61%
Neotheaflavin, from black tea, inhibits pancreatic lipase.

HY-131999

3,4,5-Trihydroxycinnamic acid decyl ester	Inhibitor	98.28%
3,4,5-Trihydroxycinnamic acid decyl ester is an excellent inhibitor of lipid absorption and accumulation, with anti-obesity properties. 3,4,5-Trihydroxycinnamic acid decyl ester is a pancreatic lipase inhibitor, with an EC₅₀ of approximately 0.9 μM.

HY-N0618

Sanggenon D	Inhibitor	99.76%
Sanggenon D is a Diels-Alder-type adduct from Chinese crude agent root bark of mulberry ( Morus alba L.). Sanggenon D possesses antioxidant and inhibits Pancreatic lipase (PL) with the an IC50 of 0.77 μM.

HY-112911

Endothelial lipase inhibitor-1	Inhibitor	98.02%
Endothelial lipase inhibitor-1 is a potent endothelial lipase inhibitor with an IC₅₀ of 49 nM.

HY-155837

hPL-IN-2	Inhibitor	98.17%
hPL-IN-2 (compound 2u) is a potent, reversible, and non-competitive inhibitor of pancreatic lipase (IC₅₀: 1.63 μM) and can be used in anti-obesity research.

HY-N2330

Lipstatin	Inhibitor
Lipstatin is a pancreatic lipase inhibitor (IC₅₀=0.14 μM), whose structure is closely related to the known inhibitor, Esterastin. Lipstatin inhibits the absorption of triglycerides without affecting the absorption of oleic acid. Lipstatin has no inhibitory effects on other pancreatic enzymes, such as phospholipase A2 and trypsin (<200 μM).

HY-N12292

Acanthopanaxoside A	Inhibitor
Acanthopanaxoside A, a triterpenoid saponin, has pancreatic lipase inhibitory action.

HY-121517

URB754	Inhibitor
URB754 is a potent inhibitor of the endocannabinoid-deactivating enzyme monoacylglycerol lipase (MGL) with an IC₅₀ of 200 nM.

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