2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Lipase
  5. Lipase Inhibitor

Lipase Inhibitor

Lipase Inhibitors (33):

Cat. No. Product Name Effect Purity
  • HY-101509
    HSL-IN-1
    		Inhibitor 98.84%
    HSL-IN-1 (compound 24b) is a potent and orally active hormone sensitive lipase (HSL) inhibitor (IC50=2 nM) with a significantly reduced reactive metabolite liability.
  • HY-153523
    Hi 76-0079
    		Inhibitor 99.90%
    Hi 76-0079 (Compound 31) is a hormone-sensitive lipase (HSL) inhibitor with an IC50 of 184 nM.
  • HY-102056
    BAY 59-9435
    		Inhibitor 98.30%
    BAY 59-9435 is a potent and selective inhibitor of Hormone Sensitive Lipase (HSL), with an IC50 of 0.023 μM.
  • HY-164714
    HSL-IN-5
    		Inhibitor 99.83%
    HSL-IN-5 (Example 21) is a hormone sensitive lipase (HSL) inhibitor (IC50: 0.25 μM). HSL-IN-5 can be used for diabetes research.
  • HY-23524
    HSL-IN-3
    		Inhibitor ≥98.0%
    HSL-IN-3 (example 42), a boronic acid ester derivative, is an inhibitor of hormone-sensitive lipase (HSL).
  • HY-14471
    Cetilistat
    		Inhibitor ≥98.0%
    Cetilistat (ATL-962), an inhibitor of pancreatic lipase, acts as an effective anti-obesity agent. Cetilistat inhibits rat and human pancreatic lipase activity with IC50s of 54.8 nM, and 5.95 nM, respectively.
  • HY-103372
    GSK264220A
    		Inhibitor 99.24%
    GSK264220A is a potent endothelial lipase inhibitor with IC50 of 16 nM. GSK264220A has the potential to decrease the risk of cardiovascular disease.
  • HY-N0618
    Sanggenon D
    		Inhibitor 99.76%
    Sanggenon D is a Diels-Alder-type adduct from Chinese crude agent root bark of mulberry ( Morus alba L.). Sanggenon D possesses antioxidant and inhibits Pancreatic lipase (PL) with the an IC50 of 0.77 μM.
  • HY-N7668
    Neotheaflavin
    		Inhibitor 99.61%
    Neotheaflavin, from black tea, inhibits pancreatic lipase.
  • HY-N0555
    Escin IB
    		Inhibitor 99.93%
    Escin IB is a saponin isolated from skin and the endosperm of seeds of horse chestnut (Aesculus hippocastanum). Escin IB shows inhibitory effect on pancreatic lipase activity.
  • HY-112911
    Endothelial lipase inhibitor-1
    		Inhibitor 98.02%
    Endothelial lipase inhibitor-1 is a potent endothelial lipase inhibitor with an IC50 of 49 nM.
  • HY-131999
    3,4,5-Trihydroxycinnamic acid decyl ester
    		Inhibitor 98.28%
    3,4,5-Trihydroxycinnamic acid decyl ester is an excellent inhibitor of lipid absorption and accumulation, with anti-obesity properties. 3,4,5-Trihydroxycinnamic acid decyl ester is a pancreatic lipase inhibitor, with an EC50 of approximately 0.9 μM.
  • HY-155837
    hPL-IN-2
    		Inhibitor 98.17%
    hPL-IN-2 (compound 2u) is a potent, reversible, and non-competitive inhibitor of pancreatic lipase (IC50: 1.63 μM) and can be used in anti-obesity research.
  • HY-N2330
    Lipstatin
    		Inhibitor
    Lipstatin is a pancreatic lipase inhibitor (IC50=0.14 μM), whose structure is closely related to the known inhibitor, Esterastin. Lipstatin inhibits the absorption of triglycerides without affecting the absorption of oleic acid. Lipstatin has no inhibitory effects on other pancreatic enzymes, such as phospholipase A2 and trypsin (<200 μM).
  • HY-N12292
    Acanthopanaxoside A
    		Inhibitor
    Acanthopanaxoside A, a triterpenoid saponin, has pancreatic lipase inhibitory action.
  • HY-121517
    URB754
    		Inhibitor
    URB754 is a potent inhibitor of the endocannabinoid-deactivating enzyme monoacylglycerol lipase (MGL) with an IC50 of 200 nM.
  • HY-157733
    1,2-Dioleoyl-3-behenoylglycerol
    		Inhibitor
    1,2-Dioleoyl-3-behenoylglycerol (BOO) inhibits pancreatic lipase activity. 1,2-Dioleoyl-3-behenoylglycerol prevents the deposition of visceral fat and hepatic triacylglycerol (TAG).
  • HY-N12294
    Ciwujianoside D2
    		Inhibitor
    Ciwujianoside D2, a saponin compound, can enhance pancreatic lipase activity in vitro.
  • HY-123862
    LAS195319
    		Inhibitor
    LAS195319 is an orally active and potent inhibitor against PI3Kδ with an IC50 value of 0.5 nM. LAS195319 is also a highly selective inhibitor against an extensive panel of proteins, lipid kinases and GPCRs. LAS195319 causes an inhibition of neutrophil and eosinophil infiltration. LAS195319 is promising for research of respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD).
  • HY-N8989
    (1,5E,11E)-Tridecatriene-7,9-diyne-3,4-diacetate
    		Inhibitor
    (1,5E,11E)-Tridecatriene-7,9-diyne-3,4-diacetate, isolated from the ethanol extract of Atractylodes lancea rhizome, displays significant lipase inhibition with an IC50 value of 23.9 µg/mL. Antiobesity Effect.