mGluR Antagonist

mGluR Antagonists (33):

Cat. No.	Product Name	Effect	Purity

HY-100371

(RS)-MCPG	Antagonist	99.05%
(RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS)-MCPG blocks theta-burst stimulation (TBS)-induced shifts in both juvenile and neonatal rat hippocampal neurons.

HY-100406

(S)-MCPG	Antagonist	99.02%
(S)-MCPG ((+)-MCPG) is a potent group I/II metabotropic glutamate receptor (mGluRs) antagonist and the active isomer of (RS)-MCPG (HY-100371). (S)-MCPG can be used for the study of the function of mGluRs in spatial learning.

HY-101226

MSOP	Antagonist	≥98.0%
MSOP is a selective group III metabotropic glutamate receptor antagonist with apparent K_D of 51 μM for the L-AP4-sensitive presynaptic mGluR.

HY-101333

CPPG	Antagonist	≥99.0%
CPPG ((RS)-CPPG) is a potent group II/III mGlu receptors antagonist. CPPG exhibits some selectivity (approximately 20 fold) for group III (IC₅₀=2.2 nM) over group II (IC₅₀=46.2 nM) mGlu receptors in the rat cerebral cortex. CPPG has weak effects at group I mGlu receptors.

HY-102094

(E/Z)-SIB-1893	Antagonist	99.79%
(E/Z)-SIB-1893 is a racemic compound of (E)-SIB-1893 and (Z)-SIB-1893 isomers. (E)-SIB-1893 is a selective non-competitive metabotropic glutamate subtype 5 receptor (mGluR5) antagonist.

HY-100372

E4CPG	Antagonist	≥98.0%
E4CPG ((RS)-ECPG) is a Group I/Group II metabotropic glutamate receptor (mGluR) antagonist. E4CPG can inhibit the paired-pulse ratio of monosynaptic inhibitory postsynaptic currents (IPSC) potentiation.

HY-103566

LY456236	Antagonist	99.81%
LY456236 is a selective, non-competitive and orally active mGlu1 receptor antagonist that inhibits phosphoinositide hydrolysis with an IC₅₀ of 0.145 μM. LY456236 also inhibits EGFR with an IC₅₀ of 0.91 μM.

HY-100409

PHCCC	Antagonist	99.92%
PHCCC is a Group I mGluR antagonist with an IC₅₀ of 3 μM. PHCCC is a selective positive modulator of mGlu4 receptor. Antiparkinsonian effect.

HY-155352

mGluR5 antagonist-1	Antagonist	98.80%
mGluR5 antagonist-1 (compound 10) is a high-affinity mGluR5 antagonist, with an IC₅₀ value of 11.5 nM. mGluR5 antagonist-1 has anti-depressant effect.

HY-119097

LY456066	Antagonist
LY456066 is a selective non-competitive metabotropic glutamate receptors (mGluR1) antagonist with an IC₅₀ value of 52.0 nM. LY456066 is effective in rodent models of anxiolysis and nociception. LY456066 reduces hyperalgesia and the amount of licking and flinching following formalin injection, which is promising for research of analgesics for chronic pain.

HY-103567

Desmethyl-YM-298198 hydrochloride	Antagonist
Desmethyl-YM-298198 hydrochloride is a high-affinity, selective, and noncompetitive mGluR1 antagonist (IC₅₀: 16 nM). Desmethyl-YM-298198 hydrochloride has analgesic effect in Streptozotocin (HY-13753)-induced hyperalgesic mice.

HY-103564

ACDPP	Antagonist
ACDPP is a specific mGluR5 antagonist. ACDPP partially bolcks the increase of fragile X mental retardation protein (FMRP) caused by DHPG (HY-12598A) (group I mGluR Agonist).

HY-103571

VU0285683	Antagonist
VU0285683 is a selective mGluR5 positive allosteric modulator (PAM). VU0285683 has anxiolytic-like activity in rodent models for anxiety.

HY-103570

MCPG sodium	Antagonist
MCPG is a carboxylic phenyl glycine. MCPG can block metabotropic glutamate receptor (mGluR)(HY-15129) and has antagonistic activity of mGluR subtype. MCPG can be used to study the induction and maintenance of long-term potentiation (LTP) .

HY-103560

(S)-HexylHIBO	Antagonist
(S)-HexylHIBO is the S-enantiomer of HexylHIBO. HexylHIBO is a group I mGluR antagonist. HexylHIBO elevates the hypothalamus-pituitary-adrenal axis response to restraint in rats. HexylHIBO is promising for research of central nervous system-related diseases.

HY-103557

Ro 64-5229	Antagonist
Ro 64-5229 is a selective, non-competitive mGlu2 antagonist. RO 64-5229 reduces the presynaptic inhibitory effect of Neuroligin 1.

HY-101247

MTPG	Antagonist
MTPG is a potent mGluR2 and mGluR3 antagonist. MTPG can block the induction of brain ischemic tolerance induced by cerebral ischemic preconditioning. MTPG also significantly attenuates the inhibitory effect of L-CCG-1 on the KCl-evoked dopamine release.

HY-110146

XAP044	Antagonist
XAP044 is a potent and selective antagonist of mGlu7. The metabotropic glutamate receptor subtype 7 (mGlu7) is an important presynaptic regulator of neurotransmission in the mammalian CNS. XAP044 demonstrates good brain exposure and wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral paradigms.

HY-135464

(±)-LY367385	Antagonist	≥98.0%
(±)-LY367385 is the racemate of LY367385. LY367385 is a highly potent and selective mGluR1a antagonist. LY367385 has an IC₅₀ of 8.8 μM for inhibits of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with > 100 μM for mGlu5a.

HY-101164

MAP4	Antagonist
MAP4 is a selective group III mGluR antagonist in some electrophysiological systems.

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