2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. LY456066

LY456066 is a selective non-competitive metabotropic glutamate receptors (mGluR1) antagonist with an IC50 value of 52.0 nM. LY456066 is effective in rodent models of anxiolysis and nociception. LY456066 reduces hyperalgesia and the amount of licking and flinching following formalin injection, which is promising for research of analgesics for chronic pain.

For research use only. We do not sell to patients.

LY456066 Chemical Structure

LY456066 Chemical Structure

CAS No. : 338738-66-2

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Based on 1 publication(s) in Google Scholar

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Description

LY456066 is a selective non-competitive metabotropic glutamate receptors (mGluR1) antagonist with an IC50 value of 52.0 nM. LY456066 is effective in rodent models of anxiolysis and nociception. LY456066 reduces hyperalgesia and the amount of licking and flinching following formalin injection, which is promising for research of analgesics for chronic pain[1][2].

Molecular Weight

341.47

Formula

C19H23N3OS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OCCSC1=NC(NC2CC3=C(C2)C=CC=C3)=C4CCCCC4=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Purity & Documentation
References
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LY456066 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY456066338738-66-2LY 456066LY-456066mGluRMetabotropic glutamate receptorsmGluR1rodent modelsanxiolysisnociceptionhyperalgesiaanalgesics for chronic painInhibitorinhibitorinhibit

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