2. Signaling Pathways
  3. PROTAC
  4. Molecular Glues

Molecular Glues

Molecular Glues

Related Products

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Protein degradation agents based on the ubiquitin-proteasome pathway include a part of molecular glues. Molecular glues are a class of small molecule compounds that can induce or stabilize the interaction between proteins. If one of the protein is ubiquitin ligase, molecular glue can cause another protein to undergo ubiquitin modification and degradation through the proteasome pathway, which is similar to PROTAC. However, these molecules are classified as ligand for E3 ligase as functional molecules in subsequent classification. Older drugs, thalidomide, lenalidomide, and pomalidomide, together with CC-90009 and CC-92480 reported later all belong to this category.

Molecular Glues Related Products (160):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-155552
    GSPT1 degrader-1
    GSPT1 degrader-1 (compound 9q) is a potent degrader of G1 to S phase transition 1 (GSPT1) via ubiquitin-proteasome system, serves as one of Molecular Glues. GSPT1 degrader-1 also induces cell G0/G1 phase arrest and apoptosis.
    GSPT1 degrader-1
  • HY-161883
    JP-2-249 3036530-41-0
    JP-2-249 is a molecular glue that acts as a potent degrader of SMARCA2. JP-2-249 shows decreasing protein level of SMARCA2 in MV-4-11 cells at 1-10 μM.
    JP-2-249
  • HY-156747
    GSPT1 degrader-2 2803879-60-7
    GSPT1 degrader-2 (Compound 210) is a potent and orally active GSPT1 molecular glue degrader (DC50: < 30 nM). GSPT1 degrader-2 is an antitumor agent.
    GSPT1 degrader-2
  • HY-162331
    STING Degrader-1
    STING Degrader-1 (compound 2), a molecular glue, is a potent STING degrader that covalently binds to STING and E3 ligase. STING Degrader-1 exhibits a "hook effect", that degrades 75% STING protein at 10 μM, and degrades ca. 30% STING protein at 30 μM.
    STING Degrader-1
  • HY-170574
    CQ627
    CQ627 is a molecular glue targeting the degradation of RIOK2. It effectively induces the degradation of RIOK2 in the MOLT4 leukemia cell line via the ubiquitin-proteasome system (UPS) by recruiting the E3 ubiquitin ligase RNF126, with a DC50 value of 410 nM. CQ627 dose-dependently induces apoptosis in MOLT4 leukemia cells, blocks their cell cycle in the G2/M phase, and exhibits antiproliferative activities in various cancer cell lines. CQ627 also demonstrates in vivo anticancer activity in a MOLT4 xenograft mouse model.
    CQ627
  • HY-153805
    Z-NCTS 1373391-77-5
    Z-NCTS is an RNA mismatch binding molecule that recognizes the 5’-r(XGG)-3’/5’-r(XGG)-3’ sequence (X=U or A) and acts as a molecular glue for RNA.
    Z-NCTS
  • HY-160533
    IKZF1-degrader-2 2915330-86-6
    IKZF1-degrader-2 (Compound 3) is an IKZF1 molecular glues degrader. IKZF1-degrader-2 has anticancer activity and low toxicity.
    IKZF1-degrader-2
  • HY-161796
    UNC8732 2929304-05-0
    UNC8732 is an NSD2 inhibitor and degrader.
    UNC8732
  • HY-163640
    CDK4 degrader 1
    CDK4 degrader 1 (ML 1–71) is a molecular glue degrader that targets CDK4.
    CDK4 degrader 1
  • HY-163810
    BRD9 Degrader-3 3033018-77-5
    BRD9 Degrader-3 (compound B20) is a BRD9 molecular glue, with a DC50 of <1.25 nM.
    BRD9 Degrader-3
  • HY-161796A
    UNC8732 TFA 2929304-06-1
    UNC8732 (TFA) is a NSD2 inhibitor and degrader.
    UNC8732 TFA
  • HY-170820
    XYD049 3006788-11-7
    XYD049 (compound 7d) is a CRBN-type molecular glue targeting GSPT1 (DC50=19 nM), which can be used for the research of MYC-driven castration-resistant prostate cancer (CRPC). XYD049 can effectively inhibit the growth of 22Rv1 cells (IC50=7 nM) and has in vivo antitumor efficacy. XYD049 downregulates the CRPC-related oncogenes in 22Rv1 cells, including AR, AR-v7, PSA, and c-Myc. XYD049 is composed of a molecular glue linker (black part) NH2-C5-NH-Boc (HY-W004710), a CRBN-type E3 ligase ligand (blue part) Thalidomide 4-fluoride (HY-41547), and a target protein ligand (red part) GSPT1 ligand-1 (HY-170821), in which the E3 ligase ligand + liner form a conjugate E3 Ligase Ligand-linker Conjugate 158 (HY-170822).
    XYD049
  • HY-169905
    GR–14-3-3 stabilizer-1 271798-59-5
    GR-14-3-3 stabilizer-1 (compound 10) is a molecular glue stabilizer that can be used to prepare molecular glues targeting glucocorticoids (GR) and block the interaction between GR and 14-3-3.
    GR–14-3-3 stabilizer-1
  • HY-162535
    GSPT1 degrader-6 3034764-41-2
    GSPT1 degrader-6 (8) is a GSPT1 molecule glue (DC50 of 13 nM).
    GSPT1 degrader-6
  • HY-153193
    LSN3160440 2765539-59-9
    LSN3160440 is an allosteric modulator of GLP-1R, which acts as a protein–protein interaction (PPI) stabilizer or molecular glue to assist in the adhesion of inactive GLP-1 (9-36) NH2 on GLP-1R.
    LSN3160440
  • HY-162536
    Pan-RAS-IN-5
    Pan-RAS-IN-5 (compound 7A) is a molecular glues that can form a ternary complex with the proteins cyclophilin A (CYPA) and RAS (ON). The formation of the ternary complex can block the binding of RAS downstream of RAF and has anti-tumor effects.
    Pan-RAS-IN-5
  • HY-169955
    WIZ degrader 8 2879251-26-8
    WIZ degrader 8 (compound 10) is a potent and selective degrader of the transcription factor WIZ, which can potently induce HbF expression. WIZ degrader 8 can lead to WIZ degradation and induce HbF expression, and has the potential to be an inhibitor of sickle cell disease.
    WIZ degrader 8
  • HY-159610
    PROTAC GSPT1 degrader-2 3024909-61-0
    PROTAC GSPT1 degrader-2 (compound A) is a GSPT1 molecule glue with more than 95% degradation. GSPT1 degrader-8 inhibits cell viability in HL-60 cells with an IC50 of 10 nM.
    PROTAC GSPT1 degrader-2
  • HY-10984S
    Pomalidomide-d5 1377838-49-7
    Pomalidomide-d5 is deuterium labeled Pomalidomide. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors.
    Pomalidomide-d<sub>5</sub>
  • HY-170430
    HGC652 3055558-98-7
    HGC652 is the molecular glue, that targets E3 ubiquitin ligase TRIM21, promotes the formation of a ternary complex between TRIM21 and NUP98, induces degradation of NUP155 and nuclear pore complex proteins, thereby causing the cell death. HGC652 inhibits the proliferation of multi cancer cells, according to the expression level of TRIM21.
    HGC652