2. Signaling Pathways
  3. GPCR/G Protein
  4. Orphan Receptor
  5. Orphan Receptor Agonist

Orphan Receptor Agonist

Orphan Receptor Agonists (19):

Cat. No. Product Name Effect Purity
  • HY-149164
    BTB09089
    		Agonist 99.43%
    BTB09089 is a T cell death-associated gene 8 (TDAG8/GPR65) specific agonist. BTB09089 increases TDAG8 expression and regulates the cytokine production of T cells and macrophages.
  • HY-115613
    ML-180
    		Agonist 99.06%
    ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist with an IC50 of 3.7 μM. ML-180 is inactive for steroidogenic factor-1 (SF-1; NR5A1; IC50>10 μM). ML-180 has the potential for LRH-1-dependent cancers.
  • HY-P1342
    Prosaptide Tx14(A)
    		Agonist 98.84%
    Prosaptide Tx14(A), a prosaposin-derived peptide, is a potent GPR37L1 and GPR37 agonist with EC50s of 5 and 7 nM, respectively. Prosaptide Tx14(A) increases both ERK1 and ERK2 phosphorylation in Schwann cells.
  • HY-109568
    Lynestrenol
    		Agonist 99.87%
    Lynestrenol is a pregnane X receptor (PXR) agonist with the EC50s of 41 and 0.23 μM for hPXR and zfPXR, respectively. Lynestrenol, a synthetic progesteronelike agent possess immunostimulatory properties.
  • HY-12664
    AF64394
    		Agonist 98.01%
    AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3.
  • HY-149913
    NR2F1 agonist 1
    		Agonist 99.83%
    NR2F1 agonist 1, a nuclear receptor NR2F1 agonist, specifically activates dormancy programs in malignant cells. NR2F1 agonist 1 up-regulates NR2F1 and downstream target genes that regulate dormancy. NR2F1 agonist 1 induces neural crest-like and growth suppression in head and neck squamous cell carcinoma (HNSCC) via NR2F1 activation. NR2F1 agonist 1 inhibits tumor growth in a mouse primary tumor model.
  • HY-156354
    GPR61 Inverse agonist 1
    		Agonist 99.33%
    GPR61 Inverse agonist 1 (Compound 1) is a GPR61 inverse agonist (IC50: 11 nM). GPR61 Inverse agonist 1 can be used for research of disorders of metabolism and body weight, such as obesity and cachexia.
  • HY-155318A
    GPR3 agonist-2
    		Agonist 98.80%
    GPR3 agonist-2(compound 32) is a potent full agonist of G protein-coupled receptor 3, with the IC50of 260 nM.
  • HY-163087
    PT-91
    		Agonist 98.25%
    PT-91 is an agonist of GPR27. PT-91 exhibits high metabolic stability and brain exposure in mice.
  • HY-114146
    CID 1375606
    		Agonist 99.90%
    CID 1375606 is a surrogate agonist of orphan G protein-coupled receptor GPR27.
  • HY-131445A
    SS-RJW100
    		Agonist 99.91%
    SS-RJW100 is a enantiomer of RJW100, which is a racemic agonist of nuclear receptor liver receptor homolog 1 (LRH-1) and steroidogenic factor 1 (SF-1). SS-RJW100 promotes recruitment of coregulator protein fragments in vitro, recruits the transcriptional intermediary factor 2 (Tif2) coactivator to LRH-1. SS-RJW100 diminishes LRH-1 allosteric activation networks, shows poor thermal stability.
  • HY-147105
    LRH-1 modulator-1
    		Agonist 98.04%
    LRH-1 modulator-1 (compound 6N) is a potent LRH-1 (liver receptor homolog-1) modulator/agonist. LRH-1 modulator-1 shows anti-inflammatory effects in intestinal organoids. LRH-1 modulator-1 induces anti-inflammatory cytokine IL-10, and reduces inflammatory cytokine IL-1b and TNFa.
  • HY-P4414
    (Des-Bromo)-Neuropeptide B (1-23) (human)
    		Agonist
    (Des-Bromo)-Neuropeptide B (1-23) (human) is an orphan G-protein coupled receptor agonist with Kis of 1.2 nM and 341 nM for GPR7 (NPBW1) and GPR8 (NPBW2), respectively.
  • HY-161115
    NR2E3 agonist 1
    		Agonist 99.48%
    NR2E3 agonist 1 (Compound 11a) is a small molecule agonist of the photoreceptor-specific nuclear receptor (NR2E3) with an EC50 value of less than 200 nM. NR2E3 agonist 1 can be used in retinitis pigmentosa research.
  • HY-164814
    GPR27 agonist-1
    		Agonist
    GPR27 Agonist-1 (compound I) is a selective GPR27 agonist with pEC50 of 6.34.
  • HY-148608
    LysoPalloT-NH-amide-C3-ph-m-O-C11
    		Agonist
    LysoPalloT-NH-amide-C3-ph-m-O-C11 is an agonist for GPR174 with an EC50 of 34 nM.
  • HY-168051
    TLX agonist 2
    		Agonist
    TLX agonist 2 (compound 31) is a TLX agonist (EC50=0.1 μM; Kd=0.16 μM). TLX agonist 2 promotes TLX transcriptional activity and enhances the expression of TLX target genes by binding to TLX. TLX agonist 2 can be used in the study of neurodegenerative diseases.
  • HY-155168
    Iso-RJW100
    		Agonist
    Iso-RJW100 (compound 24-endo) is a dual-liver receptor homologue-1 (LRH-1) and steroidogenic factor-1 (SF-1) agonist with pEC50 of 6.4 and 7.2, respectively.
  • HY-B1058A
    Benfluorex
    		Agonist
    Benfluorex (JP-992) is a hepatic nuclear factor 4 alpha (HNF4α) activator.