2. Signaling Pathways
  3. Neuronal Signaling
  4. Prion Protein
  5. Prion Protein Inhibitor

Prion Protein Inhibitor

Prion Protein Inhibitors (6):

Cat. No. Product Name Effect Purity
  • HY-138865
    BiCAPPA
    		Inhibitor 98.35%
    BiCAPPA is the first bivalent antiprion ligand. BiCAPPA can decrease infectious conformational form of prion protein (PrPSc) from scrapie-infected cells, with an EC50 of 0.32 μM.
  • HY-W081348
    1-(4-Methoxyphenyl)-3-methyl-1H-pyrazol-5(4H)-one
    		Inhibitor 99.54%
    1-(4-Methoxyphenyl)-3-methyl-1H-pyrazol-5(4H)-one (Compound 2) has antiprion activity in ScN2a and F3 cells with IC50 values of 13 nM and 25 nM, respectively.
  • HY-117856
    IND24
    		Inhibitor 99.57%
    IND24 is a potent antiprion agent with an EC50 value of 1.27 µM. IND24 decreases abnormal, misfolded, pathogenic forms of benign normally occurring prion protein on the cell surface or inside the cell.
  • HY-115360
    IND45193
    		Inhibitor
    IND45193 is a compound used to inhibit prion disease, with activity in reducing PrP(Sc) levels. In cells infected with prions, IND45193 can reduce PrP(Sc) levels, and its activity was determined through screening of multiple cell types and concentration-effect relationship studies.
  • HY-124375
    IND81
    		Inhibitor
    IND81 is an orally active antiprion with IC50 value of 1.95 μM. IND81 reduces abnormal, misfolded, disease-causing forms of benign prion proteins that are normally present on or within cells.
  • HY-134561
    6-Amino-8-trifluoromethylphenanthridine
    		Inhibitor
    6-Amino-8-trifluoromethylphenanthridine (6A-8tFP) is an antiprion agent and a derivative of 6-aminophenanthridine (HY-135189). It inhibits protein folding activity of the ribosome (PFAR) when used at a concentration of 150 μM.2 6A-8tFP directly competes with protein substrates for the ribosomal active site.