2. Neuronal Signaling
  3. Prion Protein
  4. IND24

IND24 is a potent antiprion agent with an EC50 value of 1.27 µM. IND24 decreases abnormal, misfolded, pathogenic forms of benign normally occurring prion protein on the cell surface or inside the cell.

For research use only. We do not sell to patients.

IND24 Chemical Structure

IND24 Chemical Structure

CAS No. : 1426047-44-0

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IND24 Related Antibodies

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Description

IND24 is a potent antiprion agent with an EC50 value of 1.27 µM. IND24 decreases abnormal, misfolded, pathogenic forms of benign normally occurring prion protein on the cell surface or inside the cell[1].

Molecular Weight

343.44

Formula

C21H17N3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=CC=CC(NC2=NC(C3=CC=C(C=C3)C4=CC=CC=C4)=CS2)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (363.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9117 mL 14.5586 mL 29.1172 mL
5 mM 0.5823 mL 2.9117 mL 5.8234 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9117 mL 14.5586 mL 29.1172 mL 72.7929 mL
5 mM 0.5823 mL 2.9117 mL 5.8234 mL 14.5586 mL
10 mM 0.2912 mL 1.4559 mL 2.9117 mL 7.2793 mL
15 mM 0.1941 mL 0.9706 mL 1.9411 mL 4.8529 mL
20 mM 0.1456 mL 0.7279 mL 1.4559 mL 3.6396 mL
25 mM 0.1165 mL 0.5823 mL 1.1647 mL 2.9117 mL
30 mM 0.0971 mL 0.4853 mL 0.9706 mL 2.4264 mL
40 mM 0.0728 mL 0.3640 mL 0.7279 mL 1.8198 mL
50 mM 0.0582 mL 0.2912 mL 0.5823 mL 1.4559 mL
60 mM 0.0485 mL 0.2426 mL 0.4853 mL 1.2132 mL
80 mM 0.0364 mL 0.1820 mL 0.3640 mL 0.9099 mL
100 mM 0.0291 mL 0.1456 mL 0.2912 mL 0.7279 mL
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IND24 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IND241426047-44-0IND 24IND-24Prion ProteinDCK-MDR1 CellsantiprionInhibitorinhibitorinhibit

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