Prion Protein

Prion Protein is a protein that is converted from a normal cell protein (PrPC) to a pathogenic conformation (PrPSc). PrPC is an α-helices rich membrane glycoprotein, which regulates neuronal development, synaptic function, intercellular signaling, cellular oxidative stress response, and apoptosis under normal physiological conditions. PrPC is converted into β-folding rich PrPSc under pathological conditions, leading to neuronal damage and death. Prion Protein dysfunction and misfolding causes prion diseases such as Creutzfeldt-Jakob Disease (CJD), Fatal Familial Insomnia (FFI), Gerstmann-Sträussler-Scheinker Syndrome (GSS), and other neurodegenerative diseases such as Alzheimer's Disease (AD), Parkinson's Disease (PD) or Multiple System Atrophy (MSA)^[1].

References:

[1]. Scheckel C, et al., Prions, prionoids and protein misfolding disorders. Nat Rev Genet. 2018 Jul;19(7):405-418. [Content Brief]

Prion Protein Inhibitors (6)

Prion Protein Related Products (10):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-138865

BiCAPPA	Inhibitor	98.35%
BiCAPPA is the first bivalent antiprion ligand. BiCAPPA can decrease infectious conformational form of prion protein (PrP^Sc) from scrapie-infected cells, with an EC₅₀ of 0.32 μM.

HY-P0305

PrP (106-126)
PrP (106-126) is a peptide corresponding to the prion protein (PrP) amyloidogenic region, and its biochemical properties resemble the infectious form of prion protein.

HY-W081348

1-(4-Methoxyphenyl)-3-methyl-1H-pyrazol-5(4H)-one	Inhibitor	99.54%
1-(4-Methoxyphenyl)-3-methyl-1H-pyrazol-5(4H)-one (Compound 2) has antiprion activity in ScN2a and F3 cells with IC₅₀ values of 13 nM and 25 nM, respectively.

HY-117856

IND24	Inhibitor	99.57%
IND24 is a potent antiprion agent with an EC₅₀ value of 1.27 µM. IND24 decreases abnormal, misfolded, pathogenic forms of benign normally occurring prion protein on the cell surface or inside the cell.

HY-147702

BB 0305179
BB 0305179 (compound 59) is a potent anti-prion agent, with an IC₅₀ of 4.7 μM. BB 0305179 inhibits the toxicity of a specific PrP mutant carrying a deletion in the hydrophobic domain . BB 0305179 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-115360

IND45193	Inhibitor
IND45193 is a compound used to inhibit prion disease, with activity in reducing PrP(Sc) levels. In cells infected with prions, IND45193 can reduce PrP(Sc) levels, and its activity was determined through screening of multiple cell types and concentration-effect relationship studies.

HY-124375

IND81	Inhibitor
IND81 is an orally active antiprion with IC₅₀ value of 1.95 μM. IND81 reduces abnormal, misfolded, disease-causing forms of benign prion proteins that are normally present on or within cells.

HY-153756

GFP16
GFP16 is a low affinity antiprion compound. GFP16 can be used for research of antiprion drug discovery.

HY-P10534

ccβ
CCβ is a simple 17-amino acid peptide designed in research. CCβ is able to mimic the conformational transition of proteins from α-helix to β-sheet, which is a key step in the aggregation of proteins associated with many diseases, such as Alzheimer's disease and prion disease. CCβ can be used to study diseases related to protein aggregation.

HY-134561

6-Amino-8-trifluoromethylphenanthridine	Inhibitor
6-Amino-8-trifluoromethylphenanthridine (6A-8tFP) is an antiprion agent and a derivative of 6-aminophenanthridine (HY-135189). It inhibits protein folding activity of the ribosome (PFAR) when used at a concentration of 150 μM.2 6A-8tFP directly competes with protein substrates for the ribosomal active site.

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