2. PROTAC Epigenetics
  3. PROTACs Histone Methyltransferase
  4. XF067-68

XF067-68 is a PROTAC for targeted degradation of WD40 repeat domain protein 5 (WDR5) (extracted from patent WO2019246570A1).

For research use only. We do not sell to patients.

XF067-68 Chemical Structure

XF067-68 Chemical Structure

CAS No. : 2407452-79-1

Size Price Stock Quantity
1 mg USD 158 In-stock
5 mg USD 395 In-stock
10 mg   Get quote  
50 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

XF067-68 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • Biological Activity

  • Purity & Documentation

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Description

XF067-68 is a PROTAC for targeted degradation of WD40 repeat domain protein 5 (WDR5) (extracted from patent WO2019246570A1)[1].

IC50 & Target

WDR5[1]
Molecular Weight

1030.14

Formula

C52H59F4N9O7S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C(C(C(F)(F)F)=C1)=CNC1=O)NC2=C(N3C[C@H](N([C@H](C3)C)C)C)C=CC(C4=CC(C(NCC(N[C@@H](C(C)(C)C)C(N5[C@H](C[C@@H](C5)O)C(N[C@H](C6=CC=C(C7=C(N=CS7)C)C=C6)C)=O)=O)=O)=O)=CC=C4F)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (97.07 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9707 mL 4.8537 mL 9.7074 mL
5 mM 0.1941 mL 0.9707 mL 1.9415 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9707 mL 4.8537 mL 9.7074 mL 24.2685 mL
5 mM 0.1941 mL 0.9707 mL 1.9415 mL 4.8537 mL
10 mM 0.0971 mL 0.4854 mL 0.9707 mL 2.4269 mL
15 mM 0.0647 mL 0.3236 mL 0.6472 mL 1.6179 mL
20 mM 0.0485 mL 0.2427 mL 0.4854 mL 1.2134 mL
25 mM 0.0388 mL 0.1941 mL 0.3883 mL 0.9707 mL
30 mM 0.0324 mL 0.1618 mL 0.3236 mL 0.8090 mL
40 mM 0.0243 mL 0.1213 mL 0.2427 mL 0.6067 mL
50 mM 0.0194 mL 0.0971 mL 0.1941 mL 0.4854 mL
60 mM 0.0162 mL 0.0809 mL 0.1618 mL 0.4045 mL
80 mM 0.0121 mL 0.0607 mL 0.1213 mL 0.3034 mL
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XF067-68 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XF067-682407452-79-1PROTACsHistone MethyltransferaseWDR5 relapsed cancerInhibitorinhibitorinhibit

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