2. Protein Tyrosine Kinase/RTK
  3. PDGFR
  4. Trapidil

Trapidil  (Synonyms: AR-12008)

Cat. No.: HY-B1016 Purity: ≥98.0%
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Trapidil is a vasodilator, an antiplatelet active molecule with specificity for platelet-derived growth factor.

For research use only. We do not sell to patients.

Trapidil Chemical Structure

Trapidil Chemical Structure

CAS No. : 15421-84-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 92 In-stock
Solution
10 mM * 1 mL in Water USD 92 In-stock
Solid
5 mg USD 54 In-stock
10 mg USD 84 In-stock
50 mg USD 288 In-stock
100 mg   Get quote  
200 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Trapidil:

Trapidil Related Antibodies

Top Publications Citing Use of Products

View All PDGFR Isoform Specific Products:

View All Isoforms
PDGFR PDGFRβ PDGFRα

  • Biological Activity

  • Purity & Documentation

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Description

Trapidil is a vasodilator, an antiplatelet active molecule with specificity for platelet-derived growth factor.

Clinical Trial
Molecular Weight

205.26

Formula

C10H15N5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=NC2=NC=NN2C(N(CC)CC)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : ≥ 105 mg/mL (511.55 mM)

DMSO : 100 mg/mL (487.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8719 mL 24.3594 mL 48.7187 mL
5 mM 0.9744 mL 4.8719 mL 9.7437 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (487.19 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 4.8719 mL 24.3593 mL 48.7187 mL 121.7967 mL
5 mM 0.9744 mL 4.8719 mL 9.7437 mL 24.3593 mL
10 mM 0.4872 mL 2.4359 mL 4.8719 mL 12.1797 mL
15 mM 0.3248 mL 1.6240 mL 3.2479 mL 8.1198 mL
20 mM 0.2436 mL 1.2180 mL 2.4359 mL 6.0898 mL
25 mM 0.1949 mL 0.9744 mL 1.9487 mL 4.8719 mL
30 mM 0.1624 mL 0.8120 mL 1.6240 mL 4.0599 mL
40 mM 0.1218 mL 0.6090 mL 1.2180 mL 3.0449 mL
50 mM 0.0974 mL 0.4872 mL 0.9744 mL 2.4359 mL
60 mM 0.0812 mL 0.4060 mL 0.8120 mL 2.0299 mL
80 mM 0.0609 mL 0.3045 mL 0.6090 mL 1.5225 mL
100 mM 0.0487 mL 0.2436 mL 0.4872 mL 1.2180 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Trapidil Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trapidil15421-84-8AR-12008AR12008AR 12008PDGFRPlatelet-derived growth factor receptorInhibitorinhibitorinhibit

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