2. GPCR/G Protein
  3. Adenosine Receptor
  4. Vipadenant

Vipadenant  (Synonyms: BIIB-014; CEB-4520)

Cat. No.: HY-10857 Purity: 98.02%
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Vipadenant (BIIB-014; CEB-4520) is an adenosine receptor antagonist, with Kis of 1.3 nM and 68 nM for A2A and A1, respectively.

For research use only. We do not sell to patients.

Vipadenant Chemical Structure

Vipadenant Chemical Structure

CAS No. : 442908-10-3

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10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 462 In-stock
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Based on 1 publication(s) in Google Scholar

Vipadenant Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Vipadenant

View All Adenosine Receptor Isoform Specific Products:

View All Isoforms
Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Vipadenant (BIIB-014; CEB-4520) is an adenosine receptor antagonist, with Kis of 1.3 nM and 68 nM for A2A and A1, respectively.

IC50 & Target

Ki: 1.3 nM (A2A), 68 nM (A1)[1], 1005 nM (A3)[2]
In Vivo

Vipadenant (0.3-30 mg/kg) produces a dose-dependent reduction in catalepsy. Vipadenant (10 mg/kg) does not produce any statistically significant dyskinetic episodes in 6-OHDA-lesioned rats during a 19-day dosing regimen[1]. In the mouse and rat haloperidol-induced hypolocomotion models, vipadenant has a minimum effective dose of 0.1 and 1 mg/kg, respectively. Vipadenant (3 and 10 mg/kg, p.o.) is able to increase contralateral rotations in 6-OHDA lesioned rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

321.34

Formula

C16H15N7O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

NC1=NC2=C(N=NN2CC3=CC=C(N)C(C)=C3)C(C4=CC=CO4)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 31 mg/mL (96.47 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1120 mL 15.5598 mL 31.1197 mL
5 mM 0.6224 mL 3.1120 mL 6.2239 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1120 mL 15.5598 mL 31.1197 mL 77.7992 mL
5 mM 0.6224 mL 3.1120 mL 6.2239 mL 15.5598 mL
10 mM 0.3112 mL 1.5560 mL 3.1120 mL 7.7799 mL
15 mM 0.2075 mL 1.0373 mL 2.0746 mL 5.1866 mL
20 mM 0.1556 mL 0.7780 mL 1.5560 mL 3.8900 mL
25 mM 0.1245 mL 0.6224 mL 1.2448 mL 3.1120 mL
30 mM 0.1037 mL 0.5187 mL 1.0373 mL 2.5933 mL
40 mM 0.0778 mL 0.3890 mL 0.7780 mL 1.9450 mL
50 mM 0.0622 mL 0.3112 mL 0.6224 mL 1.5560 mL
60 mM 0.0519 mL 0.2593 mL 0.5187 mL 1.2967 mL
80 mM 0.0389 mL 0.1945 mL 0.3890 mL 0.9725 mL
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Vipadenant Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vipadenant442908-10-3BIIB-014 CEB-4520BIIB014BIIB 014CEB4520CEB 4520CEB-4520Adenosine ReceptorP1 receptorInhibitorinhibitorinhibit

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