YF-2 hydrochloride

Name: YF-2 hydrochloride
Brand: MedChemExpress
SKU: HY-16531A
Rating: 5.0 (2 reviews)

Cat. No.: HY-16531A Purity: 99.61%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

YF-2 hydrochloride is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC₅₀s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease.

For research use only. We do not sell to patients.

YF-2 hydrochloride Chemical Structure

CAS No. : 1312005-62-1

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
5 mg	USD 170	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 270	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 590	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of YF-2 hydrochloride:

YF-2 In-stock

2 Publications Citing Use of MCE YF-2 hydrochloride

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

GCN5/PCAF

29.04 μM (EC₅₀)

GCN5

49.31 μM (EC₅₀)

CBP

2.75 μM (EC₅₀)

In Vitro

YF-2 (0.03, 0.1, 0.25, 0.5, 1, 2.5, 5, 15, 40 and 80 μM, 72 hours) inhibits the preliferation of U251, CCRF-CEM, Hs578T, NCI-ADR-RES cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

YF-2 (20 mg/kg, 2 hours befor electric shock or 5 mg/kg, 30 min before the electric shock, i.p.) rescues the defect in contextual memory in mice, and shows no effect on contextual memory alone at 20 mg/kg in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

467.31

Formula

C₂₀H₂₃Cl₂F₃N₂O₃

CAS No.

1312005-62-1

Appearance

Solid

Color

White to light yellow

SMILES

O=C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)C2=C(OCC)C=CC=C2OCCN(C)C.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (213.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 3.12 mg/mL (6.68 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1399 mL	10.6995 mL	21.3991 mL
5 mM	0.4280 mL	2.1399 mL	4.2798 mL
10 mM	0.2140 mL	1.0700 mL	2.1399 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.61%

Select Batch:

Data Sheet (275 KB) SDS (251 KB)

COA (253 KB) HNMR (119 KB) RP-HPLC (248 KB) LCMS (111 KB)

Handling Instructions (2659 KB)

References

[1]. FENG, Yen, et al. HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF. WO 2011072243A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.1399 mL	10.6995 mL	21.3991 mL	53.4977 mL
H₂O / DMSO	5 mM	0.4280 mL	2.1399 mL	4.2798 mL	10.6995 mL
DMSO	10 mM	0.2140 mL	1.0700 mL	2.1399 mL	5.3498 mL
	15 mM	0.1427 mL	0.7133 mL	1.4266 mL	3.5665 mL
	20 mM	0.1070 mL	0.5350 mL	1.0700 mL	2.6749 mL
	25 mM	0.0856 mL	0.4280 mL	0.8560 mL	2.1399 mL
	30 mM	0.0713 mL	0.3567 mL	0.7133 mL	1.7833 mL
	40 mM	0.0535 mL	0.2675 mL	0.5350 mL	1.3374 mL
	50 mM	0.0428 mL	0.2140 mL	0.4280 mL	1.0700 mL
	60 mM	0.0357 mL	0.1783 mL	0.3567 mL	0.8916 mL
	80 mM	0.0267 mL	0.1337 mL	0.2675 mL	0.6687 mL
	100 mM	0.0214 mL	0.1070 mL	0.2140 mL	0.5350 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.